How are evidence grades assigned?

Grades combine trial maturity, number of human studies, consistency of clinical outcomes, and regulatory status. Grade A reflects strong repeatable human data. Grade E reflects theoretical or very early emerging evidence.

What counts as a human study?

Human study counts are approximate and include interventional trials, observational cohorts, and clinically reported case evidence where available. Preclinical-only compounds are marked clearly.

How often is the index updated?

The index is updated quarterly, with targeted updates when major phase-readout or regulatory events are published.

Research Reference

Peptide Evidence Index

Grading the human evidence for 201 research peptides. Built for clinicians, health journalists, and researchers who need to separate robust trial data from preclinical signal.

Peptides Reviewed

201

Human Studies Analyzed

3,154

Last Updated

February 23, 2026

Methodology overview: how we assign Grade A-E

Grades are assigned from trial maturity, sample size consistency, endpoint reproducibility, and regulatory status.

Grade A requires strong repeatable human evidence. Grade E marks theoretical or very early compounds where mechanism exists but robust clinical signal does not.

Read full methodology

200 results

Evidence Grade Legend

AStrong Human EvidenceBModerate Human EvidenceCLimited Human EvidenceDPreclinical / Animal OnlyETheoretical / EmergingMethodology details

				Primary Endpoints		Key Finding	Action
Insulin Human InsulinRegular Insulin	Metabolic	A	280	Weight lossHbA1c reductionCognitive function	Approved	Insulin currently sits in Grade A with 280 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains robust multi-trial human evidence.	View profile →
Semaglutide OzempicWegovy	GLP-1 Agonist	A	130	Weight lossHbA1c reductionCardiovascular outcomes	Approved	Semaglutide currently sits in Grade A with 130 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains robust multi-trial human evidence.	View profile →
Octreotide SandostatinSandostatin LAR	Hormonal	A	120	Cognitive functionHormone signaling	Approved	Octreotide currently sits in Grade A with 120 estimated human studies; the strongest signals are in Cognitive function and Hormone signaling. Evidence base remains robust multi-trial human evidence.	View profile →
Liraglutide VictozaSaxenda	GLP-1 Agonist	A	115	Weight lossHbA1c reductionCardiovascular outcomes	Approved	Liraglutide currently sits in Grade A with 115 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains robust multi-trial human evidence.	View profile →
Teriparatide ForteoPTH(1-34)	Tissue Repair	A	98	Tissue repairHormone signalingLean mass	Approved	Teriparatide currently sits in Grade A with 98 estimated human studies; the strongest signals are in Tissue repair and Hormone signaling. Evidence base remains robust multi-trial human evidence.	View profile →
Desmopressin DDAVPStimate	Hormonal	A	95	HbA1c reductionHormone signaling	Approved	Desmopressin currently sits in Grade A with 95 estimated human studies; the strongest signals are in HbA1c reduction and Hormone signaling. Evidence base remains robust multi-trial human evidence.	View profile →
Bivalirudin AngiomaxAngiox	Metabolic	A	90	Cardiovascular outcomesHormone signaling	Approved	Bivalirudin currently sits in Grade A with 90 estimated human studies; the strongest signals are in Cardiovascular outcomes and Hormone signaling. Evidence base remains robust multi-trial human evidence.	View profile →
Dulaglutide TrulicityLY2189265	GLP-1 Agonist	A	86	Weight lossHbA1c reductionCardiovascular outcomes	Approved	Dulaglutide currently sits in Grade A with 86 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains robust multi-trial human evidence.	View profile →
Leuprolide LupronLupron Depot	Hormonal	A	84	Hormone signalingPain reduction	Approved	Leuprolide currently sits in Grade A with 84 estimated human studies; the strongest signals are in Hormone signaling and Pain reduction. Evidence base remains robust multi-trial human evidence.	View profile →
Exenatide ByettaBydureon	GLP-1 Agonist	A	78	Weight lossHbA1c reductionAppetite suppression	Approved	Exenatide currently sits in Grade A with 78 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains robust multi-trial human evidence.	View profile →
Tirzepatide MounjaroZepbound	GLP-1 Agonist	A	72	Weight lossHbA1c reductionSleep quality	Approved	Tirzepatide currently sits in Grade A with 72 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains robust multi-trial human evidence.	View profile →
Lanreotide SomatulineSomatuline Depot	Hormonal	A	68	Cognitive functionGI symptom reliefHormone signaling	Approved	Lanreotide currently sits in Grade A with 68 estimated human studies; the strongest signals are in Cognitive function and GI symptom relief. Evidence base remains robust multi-trial human evidence.	View profile →
Triptorelin TrelstarDecapeptyl	Hormonal	A	51	Hormone signalingPain reduction	Approved	Triptorelin currently sits in Grade A with 51 estimated human studies; the strongest signals are in Hormone signaling and Pain reduction. Evidence base remains robust multi-trial human evidence.	View profile →
Eptifibatide IntegrilinIntrifiban	Metabolic	A	49	Cardiovascular outcomes	Approved	Eptifibatide currently sits in Grade A with 49 estimated human studies; the strongest signals are in Cardiovascular outcomes. Evidence base remains robust multi-trial human evidence.	View profile →
Ziconotide PrialtSNX-111	Tissue Repair	A	44	Cognitive functionMood/anxietyPain reduction	Approved	Ziconotide currently sits in Grade A with 44 estimated human studies; the strongest signals are in Cognitive function and Mood/anxiety. Evidence base remains robust multi-trial human evidence.	View profile →
Exenatide Extended-Release BydureonBydureon BCise	GLP-1 Agonist	A	42	Weight lossHbA1c reductionCognitive function	Approved	Exenatide Extended-Release currently sits in Grade A with 42 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains robust multi-trial human evidence.	View profile →
Tesamorelin EgriftaEgrifta SV	GHRH	A	34	Weight lossCognitive functionCardiovascular outcomes	Approved	Tesamorelin currently sits in Grade A with 34 estimated human studies; the strongest signals are in Weight loss and Cognitive function. Evidence base remains robust multi-trial human evidence.	View profile →
Sermorelin GRF 1-29Geref	GHRH	A	29	Tissue repairSleep qualitySkin elasticity	Approved	Sermorelin currently sits in Grade A with 29 estimated human studies; the strongest signals are in Tissue repair and Sleep quality. Evidence base remains robust multi-trial human evidence.	View profile →
Lixisenatide AdlyxinLyxumia	GLP-1 Agonist	B	36	Weight lossHbA1c reductionAppetite suppression	Approved	Lixisenatide currently sits in Grade B with 36 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Afamelanotide ScenesseMelanotan-I	Skin	B	16	Skin elasticityHormone signalingPain reduction	Approved	Afamelanotide currently sits in Grade B with 16 estimated human studies; the strongest signals are in Skin elasticity and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Anamorelin AdlumizONO-7643	Tissue Repair	B	16	Appetite suppressionMood/anxietyHormone signaling	Approved	Anamorelin currently sits in Grade B with 16 estimated human studies; the strongest signals are in Appetite suppression and Mood/anxiety. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
B-type Natriuretic Peptide (BNP) Brain Natriuretic PeptideBNP	Metabolic	B	16	Mood/anxietyCardiovascular outcomesHormone signaling	Approved	B-type Natriuretic Peptide (BNP) currently sits in Grade B with 16 estimated human studies; the strongest signals are in Mood/anxiety and Cardiovascular outcomes. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Capromorelin EntyceCP-424391	GHRP	B	16	Appetite suppressionHormone signalingLean mass	Approved	Capromorelin currently sits in Grade B with 16 estimated human studies; the strongest signals are in Appetite suppression and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Cerebrolysin FPF-1070Cerebrolysate	Cognitive	B	16	Weight lossCognitive functionCardiovascular outcomes	Approved	Cerebrolysin currently sits in Grade B with 16 estimated human studies; the strongest signals are in Weight loss and Cognitive function. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
CGRP Calcitonin Gene-Related Peptideα-CGRP	Immune	B	16	Tissue repairInflammation reductionCognitive function	Approved	CGRP currently sits in Grade B with 16 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Goserelin ZoladexGoserelin Acetate	Hormonal	B	16	Skin elasticityHormone signalingPain reduction	Approved	Goserelin currently sits in Grade B with 16 estimated human studies; the strongest signals are in Skin elasticity and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Icatibant FirazyrHOE 140	Metabolic	B	16	Cardiovascular outcomesPain reduction	Approved	Icatibant currently sits in Grade B with 16 estimated human studies; the strongest signals are in Cardiovascular outcomes and Pain reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Macimorelin MacrilenAEZS-130	Hormonal	B	16	Hormone signaling	Approved	Macimorelin currently sits in Grade B with 16 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Mazdutide LY3305677IBI362	GLP-1 Agonist	B	16	Weight lossHbA1c reductionAppetite suppression	Approved	Mazdutide currently sits in Grade B with 16 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Nesiritide NatrecorRecombinant Human BNP	Metabolic	B	16	Cardiovascular outcomes	Approved	Nesiritide currently sits in Grade B with 16 estimated human studies; the strongest signals are in Cardiovascular outcomes. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Oxytocin PitocinSyntocinon	Hormonal	B	16	Tissue repairInflammation reductionCognitive function	Approved	Oxytocin currently sits in Grade B with 16 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Pasireotide SigniforSignifor LAR	Hormonal	B	16	Weight lossCardiovascular outcomesHormone signaling	Approved	Pasireotide currently sits in Grade B with 16 estimated human studies; the strongest signals are in Weight loss and Cardiovascular outcomes. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Pralmorelin GHRP-2 diagnosticKP-102	GHRP	B	16	Hormone signaling	Approved	Pralmorelin currently sits in Grade B with 16 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Pramlintide SymlinSymlinpen	Metabolic	B	16	Weight lossHbA1c reductionAppetite suppression	Approved	Pramlintide currently sits in Grade B with 16 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
PT-141 BremelanotideVyleesi	Hormonal	B	16	Mood/anxiety	Approved	PT-141 currently sits in Grade B with 16 estimated human studies; the strongest signals are in Mood/anxiety. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Selank TP-7Selanc	Cognitive	B	16	Cognitive functionMood/anxiety	Approved	Selank currently sits in Grade B with 16 estimated human studies; the strongest signals are in Cognitive function and Mood/anxiety. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Semax ACTH(4-10)-Pro-Gly-ProSemax 0.1%	Cognitive	B	16	Cognitive functionMood/anxietyHormone signaling	Approved	Semax currently sits in Grade B with 16 estimated human studies; the strongest signals are in Cognitive function and Mood/anxiety. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Setmelanotide ImcivreeRM-493	Metabolic	B	16	Weight lossHbA1c reductionAppetite suppression	Approved	Setmelanotide currently sits in Grade B with 16 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Somatostatin SST-14SRIF	Hormonal	B	16	Cognitive functionGI symptom reliefHormone signaling	Approved	Somatostatin currently sits in Grade B with 16 estimated human studies; the strongest signals are in Cognitive function and GI symptom relief. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Thymalin Thymic peptide extractThymaline	Immune	B	16	Inflammation reductionHormone signaling	Approved	Thymalin currently sits in Grade B with 16 estimated human studies; the strongest signals are in Inflammation reduction and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Thymosin Alpha-1 Tα1Zadaxin	Immune	B	16	Mechanistic biomarker response	Approved	Thymosin Alpha-1 currently sits in Grade B with 16 estimated human studies; the strongest signals are in Mechanistic biomarker response. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Abaloparatide TymlosBA058	Tissue Repair	B	15	Hormone signalingLean mass	Approved	Abaloparatide currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hormone signaling and Lean mass. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Abarelix PlenaxisAbarelix Depot-M	Hormonal	B	15	Hormone signaling	Approved	Abarelix currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Actovegin Deproteinized hemodialysate of calf bloodSolcoseryl	Cognitive	B	15	Weight lossHbA1c reductionTissue repair	Approved	Actovegin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Alarelin Alarelin AcetatepGlu-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt	Hormonal	B	15	Hormone signaling	Approved	Alarelin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Atosiban TractocileRWJ-22164	Hormonal	B	15	HbA1c reductionCardiovascular outcomesHormone signaling	Approved	Atosiban currently sits in Grade B with 15 estimated human studies; the strongest signals are in HbA1c reduction and Cardiovascular outcomes. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Buserelin SuprefactSuprecur	Hormonal	B	15	Hormone signalingPain reduction	Approved	Buserelin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hormone signaling and Pain reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Calcitonin MiacalcinFortical	Tissue Repair	B	15	Hormone signalingPain reduction	Approved	Calcitonin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hormone signaling and Pain reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Captopril CapotenD-2-methyl-3-mercaptopropanoyl-L-proline	Metabolic	B	15	HbA1c reductionCardiovascular outcomes	Approved	Captopril currently sits in Grade B with 15 estimated human studies; the strongest signals are in HbA1c reduction and Cardiovascular outcomes. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Carbetocin PabalDuratocin	Hormonal	B	15	Hormone signaling	Approved	Carbetocin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Carperitide hANPHANP	Metabolic	B	15	Cardiovascular outcomesHormone signaling	Approved	Carperitide currently sits in Grade B with 15 estimated human studies; the strongest signals are in Cardiovascular outcomes and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Cetrorelix CetrotideCetrorelix Acetate	Hormonal	B	15	Hormone signaling	Approved	Cetrorelix currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Colistin Polymyxin EColistimethate Sodium	Immune	B	15	Inflammation reductionCognitive functionHormone signaling	Approved	Colistin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Inflammation reduction and Cognitive function. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Cortexin КортексинCortexinum	Cognitive	B	15	Weight lossInflammation reductionCognitive function	Approved	Cortexin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Weight loss and Inflammation reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Corticotropin ACTHAdrenocorticotropic Hormone	Hormonal	B	15	Inflammation reductionCognitive functionHormone signaling	Approved	Corticotropin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Inflammation reduction and Cognitive function. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Cosyntropin CortrosynTetracosactide	Hormonal	B	15	Hormone signaling	Approved	Cosyntropin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Cyclosporine CiclosporinCyclosporin A	Immune	B	15	Inflammation reductionCardiovascular outcomes	Approved	Cyclosporine currently sits in Grade B with 15 estimated human studies; the strongest signals are in Inflammation reduction and Cardiovascular outcomes. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Daptomycin CubicinCubicin RF	Immune	B	15	Inflammation reductionSkin elasticity	Approved	Daptomycin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Inflammation reduction and Skin elasticity. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Degarelix FirmagonDegarelix Acetate	Hormonal	B	15	Cardiovascular outcomesHormone signaling	Approved	Degarelix currently sits in Grade B with 15 estimated human studies; the strongest signals are in Cardiovascular outcomes and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Difelikefalin KorsuvaCR845	Hormonal	B	15	Inflammation reductionSleep qualityMood/anxiety	Approved	Difelikefalin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Inflammation reduction and Sleep quality. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Ecallantide KalbitorDX-88	Immune	B	15	Inflammation reductionHormone signaling	Approved	Ecallantide currently sits in Grade B with 15 estimated human studies; the strongest signals are in Inflammation reduction and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Elcatonin ElcitoninCarbocalcitonin	Tissue Repair	B	15	Hormone signalingPain reduction	Approved	Elcatonin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hormone signaling and Pain reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Enfuvirtide FuzeonT-20	Immune	B	15	Inflammation reduction	Approved	Enfuvirtide currently sits in Grade B with 15 estimated human studies; the strongest signals are in Inflammation reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Etelcalcetide ParsabivAMG 416	Tissue Repair	B	15	Cardiovascular outcomesHormone signaling	Approved	Etelcalcetide currently sits in Grade B with 15 estimated human studies; the strongest signals are in Cardiovascular outcomes and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Ganirelix AntagonOrgalutran	Hormonal	B	15	Hormone signaling	Approved	Ganirelix currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Glucagon GlucaGenBaqsimi	Metabolic	B	15	Weight lossHbA1c reductionHormone signaling	Approved	Glucagon currently sits in Grade B with 15 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Glutathione GSHL-Glutathione	Longevity	B	15	HbA1c reductionCognitive functionMood/anxiety	Approved	Glutathione currently sits in Grade B with 15 estimated human studies; the strongest signals are in HbA1c reduction and Cognitive function. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Gonadorelin GnRHGonadotropin-Releasing Hormone	Hormonal	B	15	Hair growthHormone signaling	Approved	Gonadorelin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hair growth and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Histrelin VantasSupprelin LA	Hormonal	B	15	Hormone signaling	Approved	Histrelin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Linaclotide LinzessConstella	Metabolic	B	15	Cognitive functionGI symptom reliefPain reduction	Approved	Linaclotide currently sits in Grade B with 15 estimated human studies; the strongest signals are in Cognitive function and GI symptom relief. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Lutetium-177 DOTATATE Lutathera¹⁷⁷Lu-DOTATATE	Hormonal	B	15	Cognitive functionGI symptom reliefHormone signaling	Approved	Lutetium-177 DOTATATE currently sits in Grade B with 15 estimated human studies; the strongest signals are in Cognitive function and GI symptom relief. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Mecasermin IncrelexRecombinant Human IGF-1	Tissue Repair	B	15	Cognitive functionCardiovascular outcomesHormone signaling	Approved	Mecasermin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Cognitive function and Cardiovascular outcomes. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Nafarelin SynarelNafarelin Acetate	Hormonal	B	15	Hormone signalingPain reduction	Approved	Nafarelin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hormone signaling and Pain reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Nisin Nisin ANisin Z	Immune	B	15	Tissue repairInflammation reduction	Approved	Nisin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Noopept GVS-111N-phenylacetyl-L-prolylglycine ethyl ester	Cognitive	B	15	Cognitive functionMood/anxietyGI symptom relief	Approved	Noopept currently sits in Grade B with 15 estimated human studies; the strongest signals are in Cognitive function and Mood/anxiety. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Pegcetacoplan EmpaveliSyfovre	Immune	B	15	Inflammation reductionCardiovascular outcomes	Approved	Pegcetacoplan currently sits in Grade B with 15 estimated human studies; the strongest signals are in Inflammation reduction and Cardiovascular outcomes. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Plecanatide TrulanceSP-304	Metabolic	B	15	GI symptom reliefHormone signalingPain reduction	Approved	Plecanatide currently sits in Grade B with 15 estimated human studies; the strongest signals are in GI symptom relief and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Polymyxin B Polymyxin B SulfatePMB	Immune	B	15	Inflammation reductionHormone signaling	Approved	Polymyxin B currently sits in Grade B with 15 estimated human studies; the strongest signals are in Inflammation reduction and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Protirelin TRHThyrotropin-Releasing Hormone	Hormonal	B	15	Cognitive functionMood/anxietyHormone signaling	Approved	Protirelin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Cognitive function and Mood/anxiety. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Romiplostim NplateAMG 531	Immune	B	15	Inflammation reduction	Approved	Romiplostim currently sits in Grade B with 15 estimated human studies; the strongest signals are in Inflammation reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Secretin SecreFloChiRhoStim	Metabolic	B	15	Cognitive functionHormone signaling	Approved	Secretin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Cognitive function and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Taltirelin CeredistTA-0910	Cognitive	B	15	Cognitive functionHormone signaling	Approved	Taltirelin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Cognitive function and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Teduglutide GattexRevestive	Metabolic	B	15	Weight lossGI symptom reliefHormone signaling	Approved	Teduglutide currently sits in Grade B with 15 estimated human studies; the strongest signals are in Weight loss and GI symptom relief. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Thymogen Glu-TrpEW dipeptide	Immune	B	15	Inflammation reduction	Approved	Thymogen currently sits in Grade B with 15 estimated human studies; the strongest signals are in Inflammation reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Thymopentin TP-5Thymopoietin Pentapeptide	Immune	B	15	Inflammation reductionHormone signaling	Approved	Thymopentin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Inflammation reduction and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Vancomycin VancocinFirvanq	Immune	B	15	Inflammation reductionCognitive function	Approved	Vancomycin currently sits in Grade B with 15 estimated human studies; the strongest signals are in Inflammation reduction and Cognitive function. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Vapreotide SanvarRC-160	Metabolic	B	15	Cognitive functionHormone signaling	Approved	Vapreotide currently sits in Grade B with 15 estimated human studies; the strongest signals are in Cognitive function and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Vasopressin ADHAntidiuretic Hormone	Hormonal	B	15	HbA1c reductionCardiovascular outcomesHormone signaling	Approved	Vasopressin currently sits in Grade B with 15 estimated human studies; the strongest signals are in HbA1c reduction and Cardiovascular outcomes. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Vosoritide VoxzogoBMN 111	Tissue Repair	B	15	Hormone signaling	Approved	Vosoritide currently sits in Grade B with 15 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
GHK-Cu Copper Peptide GHK-CuGlycyl-L-histidyl-L-lysine:copper(II)	Skin	B	13	Tissue repairInflammation reductionCognitive function	Phase 2	GHK-Cu currently sits in Grade B with 13 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Retatrutide LY3437943Reta	GLP-1 Agonist	B	11	Weight lossHbA1c reductionAppetite suppression	Phase 3	Retatrutide currently sits in Grade B with 11 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
CJC-1295 Modified GRF 1-29Mod GRF 1-29	GHRH	B	3	Tissue repairHormone signalingLean mass	Research Only	CJC-1295 currently sits in Grade B with 3 estimated human studies; the strongest signals are in Tissue repair and Hormone signaling. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
Ipamorelin IPAIpamorelin Acetate	GHRP	B	3	Weight lossAppetite suppressionSleep quality	Research Only	Ipamorelin currently sits in Grade B with 3 estimated human studies; the strongest signals are in Weight loss and Appetite suppression. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
TB-500 Thymosin Beta-4Tβ4	Tissue Repair	B	3	Tissue repairInflammation reductionHair growth	Research Only	TB-500 currently sits in Grade B with 3 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
BPC-157 Body Protection Compound-157Bepecin	Tissue Repair	B	0	Tissue repairInflammation reductionCognitive function	Preclinical	BPC-157 currently sits in Grade B with 0 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains moderate human evidence with early clinical consistency.	View profile →
CagriSema Cagrilintide/SemaglutideNNC9204-1706/Semaglutide	GLP-1 Agonist	C	11	Weight lossHbA1c reductionAppetite suppression	Phase 3	CagriSema currently sits in Grade C with 11 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Orforglipron LY3502970Oral GLP-1	GLP-1 Agonist	C	11	Weight lossHbA1c reductionHormone signaling	Phase 3	Orforglipron currently sits in Grade C with 11 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
SS-31 ElamipretideBendavia	Longevity	C	11	Cardiovascular outcomesLean mass	Phase 3	SS-31 currently sits in Grade C with 11 estimated human studies; the strongest signals are in Cardiovascular outcomes and Lean mass. Evidence base remains limited but signal-positive human evidence.	View profile →
Survodutide BI 456906BI-456906	GLP-1 Agonist	C	11	Weight lossHormone signaling	Phase 3	Survodutide currently sits in Grade C with 11 estimated human studies; the strongest signals are in Weight loss and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Aviptadil RLF-100Synthetic VIP	Immune	C	10	Inflammation reductionCognitive functionMood/anxiety	Phase 3	Aviptadil currently sits in Grade C with 10 estimated human studies; the strongest signals are in Inflammation reduction and Cognitive function. Evidence base remains limited but signal-positive human evidence.	View profile →
Glucose-dependent Insulinotropic Polypeptide GIPGastric Inhibitory Polypeptide	GLP-1 Agonist	C	10	Weight lossHbA1c reductionHormone signaling	Phase 3	Glucose-dependent Insulinotropic Polypeptide currently sits in Grade C with 10 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Ularitide UrodilatinCDD/ANP 95-126	Metabolic	C	10	Cardiovascular outcomesHormone signaling	Phase 3	Ularitide currently sits in Grade C with 10 estimated human studies; the strongest signals are in Cardiovascular outcomes and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Adrenomedullin ADMAM	Metabolic	C	7	Inflammation reductionCardiovascular outcomesHormone signaling	Phase 2	Adrenomedullin currently sits in Grade C with 7 estimated human studies; the strongest signals are in Inflammation reduction and Cardiovascular outcomes. Evidence base remains limited but signal-positive human evidence.	View profile →
Angiotensin-(1-7) Ang-(1-7)Angiotensin 1-7	Metabolic	C	7	Inflammation reductionCardiovascular outcomesHormone signaling	Phase 2	Angiotensin-(1-7) currently sits in Grade C with 7 estimated human studies; the strongest signals are in Inflammation reduction and Cardiovascular outcomes. Evidence base remains limited but signal-positive human evidence.	View profile →
AOD-9604 Anti-Obesity Drug 9604hGH Fragment 177-191	Metabolic	C	7	Weight lossHbA1c reductionAppetite suppression	Phase 2	AOD-9604 currently sits in Grade C with 7 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Atrial Natriuretic Peptide (ANP) Atrial Natriuretic FactorANF	Metabolic	C	7	Cardiovascular outcomesHormone signaling	Phase 2	Atrial Natriuretic Peptide (ANP) currently sits in Grade C with 7 estimated human studies; the strongest signals are in Cardiovascular outcomes and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Collagen Peptides Hydrolyzed CollagenCollagen Hydrolysate	Skin	C	7	Tissue repairSkin elasticityGI symptom relief	Phase 2	Collagen Peptides currently sits in Grade C with 7 estimated human studies; the strongest signals are in Tissue repair and Skin elasticity. Evidence base remains limited but signal-positive human evidence.	View profile →
Danuglipron PF-06882961Pfizer oral GLP-1	GLP-1 Agonist	C	7	Weight lossHbA1c reductionGI symptom relief	Phase 2	Danuglipron currently sits in Grade C with 7 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Kisspeptin-10 Metastin 45-54KP-10	Hormonal	C	7	Cognitive functionMood/anxietyHormone signaling	Phase 2	Kisspeptin-10 currently sits in Grade C with 7 estimated human studies; the strongest signals are in Cognitive function and Mood/anxiety. Evidence base remains limited but signal-positive human evidence.	View profile →
Kisspeptin-54 MetastinKP-54	Hormonal	C	7	Cognitive functionHormone signaling	Phase 2	Kisspeptin-54 currently sits in Grade C with 7 estimated human studies; the strongest signals are in Cognitive function and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
MK-677 IbutamorenIbutamoren Mesylate	GHRP	C	7	Sleep qualityHormone signalingLean mass	Phase 2	MK-677 currently sits in Grade C with 7 estimated human studies; the strongest signals are in Sleep quality and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
NAD+ Nicotinamide Adenine DinucleotideNAD	Longevity	C	7	HbA1c reductionTissue repairCognitive function	Phase 2	NAD+ currently sits in Grade C with 7 estimated human studies; the strongest signals are in HbA1c reduction and Tissue repair. Evidence base remains limited but signal-positive human evidence.	View profile →
Pemvidutide ALT-801Altimmune GLP-1/glucagon	GLP-1 Agonist	C	7	Weight lossHbA1c reductionInflammation reduction	Phase 2	Pemvidutide currently sits in Grade C with 7 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Thymosin Beta-4 Tβ4TB4	Immune	C	7	Tissue repairInflammation reductionCognitive function	Phase 2	Thymosin Beta-4 currently sits in Grade C with 7 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Amylin Islet Amyloid PolypeptideIAPP	Metabolic	C	6	Weight lossHbA1c reductionAppetite suppression	Phase 2	Amylin currently sits in Grade C with 6 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
ARA-290 CibinetideARA 290	Tissue Repair	C	6	HbA1c reductionTissue repairInflammation reduction	Phase 2	ARA-290 currently sits in Grade C with 6 estimated human studies; the strongest signals are in HbA1c reduction and Tissue repair. Evidence base remains limited but signal-positive human evidence.	View profile →
Carnosine L-CarnosineBeta-Alanyl-L-Histidine	Longevity	C	6	Tissue repairCognitive functionMood/anxiety	Phase 2	Carnosine currently sits in Grade C with 6 estimated human studies; the strongest signals are in Tissue repair and Cognitive function. Evidence base remains limited but signal-positive human evidence.	View profile →
Chlorotoxin CTXClTx	Hormonal	C	6	Cognitive functionHormone signalingPain reduction	Phase 2	Chlorotoxin currently sits in Grade C with 6 estimated human studies; the strongest signals are in Cognitive function and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
CNTF Peptide Ciliary Neurotrophic Factor peptide fragmentCNTF-derived neuropeptide	Cognitive	C	6	Weight lossTissue repairInflammation reduction	Phase 2	CNTF Peptide currently sits in Grade C with 6 estimated human studies; the strongest signals are in Weight loss and Tissue repair. Evidence base remains limited but signal-positive human evidence.	View profile →
Davunetide NAPAL-108	Cognitive	C	6	Cognitive functionMood/anxiety	Phase 2	Davunetide currently sits in Grade C with 6 estimated human studies; the strongest signals are in Cognitive function and Mood/anxiety. Evidence base remains limited but signal-positive human evidence.	View profile →
Ghrelin GHRLLenomorelin	GHRP	C	6	Weight lossHbA1c reductionAppetite suppression	Phase 2	Ghrelin currently sits in Grade C with 6 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
GLP-2 Glucagon-Like Peptide-2GLP-2 (1-33)	Metabolic	C	6	Tissue repairInflammation reductionCognitive function	Phase 2	GLP-2 currently sits in Grade C with 6 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Magainin 2 Magainin IIMagainin-2	Immune	C	6	Tissue repairInflammation reductionSkin elasticity	Phase 2	Magainin 2 currently sits in Grade C with 6 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Motilin MLNMotilin Peptide	Metabolic	C	6	GI symptom reliefHormone signaling	Phase 2	Motilin currently sits in Grade C with 6 estimated human studies; the strongest signals are in GI symptom relief and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
PACAP Pituitary Adenylate Cyclase-Activating PolypeptidePACAP-38	Cognitive	C	6	Inflammation reductionCognitive functionMood/anxiety	Phase 2	PACAP currently sits in Grade C with 6 estimated human studies; the strongest signals are in Inflammation reduction and Cognitive function. Evidence base remains limited but signal-positive human evidence.	View profile →
Palmitoyl Tetrapeptide-7 Pal-GQPRPalmitoyl Tetrapeptide-3	Skin	C	6	Inflammation reductionSkin elasticityHormone signaling	Phase 2	Palmitoyl Tetrapeptide-7 currently sits in Grade C with 6 estimated human studies; the strongest signals are in Inflammation reduction and Skin elasticity. Evidence base remains limited but signal-positive human evidence.	View profile →
Palmitoyl Tripeptide-1 Pal-GHKPalmitoyl Oligopeptide	Skin	C	6	Skin elasticityHormone signaling	Phase 2	Palmitoyl Tripeptide-1 currently sits in Grade C with 6 estimated human studies; the strongest signals are in Skin elasticity and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Palmitoyl Tripeptide-38 Matrixyl Synthe'6Matrixyl Synthe 6	Skin	C	6	Tissue repairSkin elasticityHormone signaling	Phase 2	Palmitoyl Tripeptide-38 currently sits in Grade C with 6 estimated human studies; the strongest signals are in Tissue repair and Skin elasticity. Evidence base remains limited but signal-positive human evidence.	View profile →
Palmitoyl Tripeptide-5 Syn-CollThrombospondin-1 Mimetic	Skin	C	6	Skin elasticityHormone signaling	Phase 2	Palmitoyl Tripeptide-5 currently sits in Grade C with 6 estimated human studies; the strongest signals are in Skin elasticity and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Peptide YY PYYPYY3-36	GLP-1 Agonist	C	6	Weight lossHbA1c reductionAppetite suppression	Phase 2	Peptide YY currently sits in Grade C with 6 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Syn-Ake Dipeptide Diaminobutyroyl Benzylamide DiacetateSnake Venom Peptide	Skin	C	6	Cognitive functionSkin elasticityHormone signaling	Phase 2	Syn-Ake currently sits in Grade C with 6 estimated human studies; the strongest signals are in Cognitive function and Skin elasticity. Evidence base remains limited but signal-positive human evidence.	View profile →
Tabimorelin NN703NNC 26-0161	GHRP	C	6	Hormone signaling	Phase 2	Tabimorelin currently sits in Grade C with 6 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
TB-4 Fragment (Ac-SDKP) Ac-SDKPN-Acetyl-Ser-Asp-Lys-Pro	Tissue Repair	C	6	Tissue repairInflammation reductionMood/anxiety	Phase 2	TB-4 Fragment (Ac-SDKP) currently sits in Grade C with 6 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Apelin Apelin-13Apelin-36	Metabolic	C	4	HbA1c reductionCardiovascular outcomesHormone signaling	Phase 1	Apelin currently sits in Grade C with 4 estimated human studies; the strongest signals are in HbA1c reduction and Cardiovascular outcomes. Evidence base remains limited but signal-positive human evidence.	View profile →
Uroguanylin UGNProuroguanylin	Metabolic	C	4	Appetite suppressionCognitive functionCardiovascular outcomes	Phase 1	Uroguanylin currently sits in Grade C with 4 estimated human studies; the strongest signals are in Appetite suppression and Cognitive function. Evidence base remains limited but signal-positive human evidence.	View profile →
5-Amino-1MQ 5-Amino-1-Methylquinolinium5-Amino-1-MethylQuinolinium chloride	Metabolic	C	3	Weight lossAppetite suppressionHormone signaling	Research Only	5-Amino-1MQ currently sits in Grade C with 3 estimated human studies; the strongest signals are in Weight loss and Appetite suppression. Evidence base remains limited but signal-positive human evidence.	View profile →
Argireline Acetyl Hexapeptide-3Acetyl Hexapeptide-8	Skin	C	3	Cognitive functionSkin elasticityLean mass	Research Only	Argireline currently sits in Grade C with 3 estimated human studies; the strongest signals are in Cognitive function and Skin elasticity. Evidence base remains limited but signal-positive human evidence.	View profile →
Beta-Endorphin β-EndorphinBeta-EP	Cognitive	C	3	Inflammation reductionSleep qualityMood/anxiety	Research Only	Beta-Endorphin currently sits in Grade C with 3 estimated human studies; the strongest signals are in Inflammation reduction and Sleep quality. Evidence base remains limited but signal-positive human evidence.	View profile →
Cholecystokinin CCKCCK-8	Metabolic	C	3	Weight lossHbA1c reductionAppetite suppression	Research Only	Cholecystokinin currently sits in Grade C with 3 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
CJC-1295 DAC CJC-1295 with DACCJC-1295 with Drug Affinity Complex	GHRH	C	3	Hormone signaling	Research Only	CJC-1295 DAC currently sits in Grade C with 3 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Cortagen AEDPAla-Glu-Asp-Pro	Cognitive	C	3	Cognitive functionMood/anxietyHormone signaling	Research Only	Cortagen currently sits in Grade C with 3 estimated human studies; the strongest signals are in Cognitive function and Mood/anxiety. Evidence base remains limited but signal-positive human evidence.	View profile →
Dihexa N-hexanoic-Tyr-Ile-(6) aminohexanoic amideHexanoyl-Tyrosine-Isoleucine-Aminohexanoic amide	Cognitive	C	3	Cognitive functionHormone signaling	Research Only	Dihexa currently sits in Grade C with 3 estimated human studies; the strongest signals are in Cognitive function and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
DSIP Delta Sleep-Inducing PeptideDelta Sleep Peptide	Cognitive	C	3	Cognitive functionSleep qualityMood/anxiety	Research Only	DSIP currently sits in Grade C with 3 estimated human studies; the strongest signals are in Cognitive function and Sleep quality. Evidence base remains limited but signal-positive human evidence.	View profile →
Dynorphin Dynorphin ADynorphin B	Cognitive	C	3	Cognitive functionMood/anxietyPain reduction	Research Only	Dynorphin currently sits in Grade C with 3 estimated human studies; the strongest signals are in Cognitive function and Mood/anxiety. Evidence base remains limited but signal-positive human evidence.	View profile →
Epithalon EpitalonEpithalone	Longevity	C	3	Sleep qualityHormone signaling	Research Only	Epithalon currently sits in Grade C with 3 estimated human studies; the strongest signals are in Sleep quality and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Follistatin FSTFS-344	Tissue Repair	C	3	Hair growthHormone signalingLean mass	Research Only	Follistatin currently sits in Grade C with 3 estimated human studies; the strongest signals are in Hair growth and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Galanin GALGalanin-29	Cognitive	C	3	Cognitive functionMood/anxietyHormone signaling	Research Only	Galanin currently sits in Grade C with 3 estimated human studies; the strongest signals are in Cognitive function and Mood/anxiety. Evidence base remains limited but signal-positive human evidence.	View profile →
GHK Glycyl-L-Histidyl-L-LysineGHK tripeptide	Skin	C	3	Tissue repairInflammation reductionSkin elasticity	Research Only	GHK currently sits in Grade C with 3 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
GHRP-2 Growth Hormone Releasing Peptide-2Pralmorelin	GHRP	C	3	Appetite suppressionSleep qualityHormone signaling	Research Only	GHRP-2 currently sits in Grade C with 3 estimated human studies; the strongest signals are in Appetite suppression and Sleep quality. Evidence base remains limited but signal-positive human evidence.	View profile →
GHRP-6 Growth Hormone Releasing Peptide-6Growth Hormone Releasing Hexapeptide	GHRP	C	3	Weight lossAppetite suppressionCognitive function	Research Only	GHRP-6 currently sits in Grade C with 3 estimated human studies; the strongest signals are in Weight loss and Appetite suppression. Evidence base remains limited but signal-positive human evidence.	View profile →
Hexarelin ExamorelinHEX	GHRP	C	3	Tissue repairCardiovascular outcomesHormone signaling	Research Only	Hexarelin currently sits in Grade C with 3 estimated human studies; the strongest signals are in Tissue repair and Cardiovascular outcomes. Evidence base remains limited but signal-positive human evidence.	View profile →
Humanin HNHumanin peptide	Cognitive	C	3	HbA1c reductionCognitive functionMood/anxiety	Research Only	Humanin currently sits in Grade C with 3 estimated human studies; the strongest signals are in HbA1c reduction and Cognitive function. Evidence base remains limited but signal-positive human evidence.	View profile →
IGF-1 LR3 Long R3 IGF-1Insulin-like Growth Factor 1 Long R3	Tissue Repair	C	3	HbA1c reductionHormone signalingLean mass	Research Only	IGF-1 LR3 currently sits in Grade C with 3 estimated human studies; the strongest signals are in HbA1c reduction and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
KPV Lys-Pro-Valα-MSH(11-13)	Immune	C	3	Tissue repairInflammation reductionSkin elasticity	Research Only	KPV currently sits in Grade C with 3 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
LL-37 CathelicidinhCAP18 C-terminal peptide	Immune	C	3	Tissue repairInflammation reductionHormone signaling	Research Only	LL-37 currently sits in Grade C with 3 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Matrixyl Palmitoyl Pentapeptide-4pal-KTTKS	Skin	C	3	Skin elasticityHormone signaling	Research Only	Matrixyl currently sits in Grade C with 3 estimated human studies; the strongest signals are in Skin elasticity and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Melanotan II MT-2MT-II	Hormonal	C	3	Weight lossAppetite suppressionSkin elasticity	Research Only	Melanotan II currently sits in Grade C with 3 estimated human studies; the strongest signals are in Weight loss and Appetite suppression. Evidence base remains limited but signal-positive human evidence.	View profile →
MGF Mechano Growth FactorIGF-1Ec	Tissue Repair	C	3	Tissue repairCognitive functionHormone signaling	Research Only	MGF currently sits in Grade C with 3 estimated human studies; the strongest signals are in Tissue repair and Cognitive function. Evidence base remains limited but signal-positive human evidence.	View profile →
Modified GRF 1-29 Mod GRF 1-29CJC-1295 without DAC	GHRH	C	3	Tissue repairSleep qualityHormone signaling	Research Only	Modified GRF 1-29 currently sits in Grade C with 3 estimated human studies; the strongest signals are in Tissue repair and Sleep quality. Evidence base remains limited but signal-positive human evidence.	View profile →
N-Acetyl Semax Amidate NASAAc-Semax-NH₂	Cognitive	C	3	Cognitive functionMood/anxietyHormone signaling	Research Only	N-Acetyl Semax Amidate currently sits in Grade C with 3 estimated human studies; the strongest signals are in Cognitive function and Mood/anxiety. Evidence base remains limited but signal-positive human evidence.	View profile →
Neuropeptide Y NPYNeuropeptide Tyrosine	Cognitive	C	3	Weight lossAppetite suppressionCognitive function	Research Only	Neuropeptide Y currently sits in Grade C with 3 estimated human studies; the strongest signals are in Weight loss and Appetite suppression. Evidence base remains limited but signal-positive human evidence.	View profile →
Neurotensin NTNeurotensin 1-13	Cognitive	C	3	HbA1c reductionCognitive functionMood/anxiety	Research Only	Neurotensin currently sits in Grade C with 3 estimated human studies; the strongest signals are in HbA1c reduction and Cognitive function. Evidence base remains limited but signal-positive human evidence.	View profile →
Orexin-A Hypocretin-1HCRT-1	Cognitive	C	3	Appetite suppressionCognitive functionSleep quality	Research Only	Orexin-A currently sits in Grade C with 3 estimated human studies; the strongest signals are in Appetite suppression and Cognitive function. Evidence base remains limited but signal-positive human evidence.	View profile →
Pinealon EDRGlu-Asp-Arg	Cognitive	C	3	Cognitive functionSleep qualityMood/anxiety	Research Only	Pinealon currently sits in Grade C with 3 estimated human studies; the strongest signals are in Cognitive function and Sleep quality. Evidence base remains limited but signal-positive human evidence.	View profile →
Snap-8 Acetyl Octapeptide-3SNAP-8 peptide	Skin	C	3	Cognitive functionSkin elasticityHormone signaling	Research Only	Snap-8 currently sits in Grade C with 3 estimated human studies; the strongest signals are in Cognitive function and Skin elasticity. Evidence base remains limited but signal-positive human evidence.	View profile →
Substance P SPNeurokinin A precursor	Immune	C	3	Tissue repairInflammation reductionCognitive function	Research Only	Substance P currently sits in Grade C with 3 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Thymulin Facteur Thymique SériqueFTS	Immune	C	3	Inflammation reductionCognitive functionHormone signaling	Phase 1	Thymulin currently sits in Grade C with 3 estimated human studies; the strongest signals are in Inflammation reduction and Cognitive function. Evidence base remains limited but signal-positive human evidence.	View profile →
VIP (Vasoactive Intestinal Peptide) Vasoactive Intestinal PeptideVIP	Immune	C	3	Inflammation reductionCognitive functionGI symptom relief	Research Only	VIP (Vasoactive Intestinal Peptide) currently sits in Grade C with 3 estimated human studies; the strongest signals are in Inflammation reduction and Cognitive function. Evidence base remains limited but signal-positive human evidence.	View profile →
Acetyl Tetrapeptide-5 EyeserylAnti-Edema Peptide	Skin	C	2	Skin elasticityCardiovascular outcomes	Research Only	Acetyl Tetrapeptide-5 currently sits in Grade C with 2 estimated human studies; the strongest signals are in Skin elasticity and Cardiovascular outcomes. Evidence base remains limited but signal-positive human evidence.	View profile →
BDNF Mimetic Peptides LM22A-4TrkB agonist peptides	Cognitive	C	2	Cognitive functionMood/anxietyHormone signaling	Research Only	BDNF Mimetic Peptides currently sits in Grade C with 2 estimated human studies; the strongest signals are in Cognitive function and Mood/anxiety. Evidence base remains limited but signal-positive human evidence.	View profile →
Bronchogen Ala-Glu-Asp-LeuAEDL tetrapeptide	Immune	C	2	Inflammation reductionLean mass	Research Only	Bronchogen currently sits in Grade C with 2 estimated human studies; the strongest signals are in Inflammation reduction and Lean mass. Evidence base remains limited but signal-positive human evidence.	View profile →
Cardiogen Ala-Glu-Asp-ArgAEDR tetrapeptide	Longevity	C	2	Mood/anxietyCardiovascular outcomes	Research Only	Cardiogen currently sits in Grade C with 2 estimated human studies; the strongest signals are in Mood/anxiety and Cardiovascular outcomes. Evidence base remains limited but signal-positive human evidence.	View profile →
Cathelicidin hCAP-18hCAP18	Immune	C	2	Inflammation reduction	Research Only	Cathelicidin currently sits in Grade C with 2 estimated human studies; the strongest signals are in Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Chonluten Thr-Glu-Asp-GlyTEDG tetrapeptide	Immune	C	2	Inflammation reduction	Research Only	Chonluten currently sits in Grade C with 2 estimated human studies; the strongest signals are in Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Colivelin ADNF-9-humanin hybrid peptideAGA-(C8R)HNG17 hybrid peptide	Cognitive	C	2	Cognitive functionHormone signaling	Research Only	Colivelin currently sits in Grade C with 2 estimated human studies; the strongest signals are in Cognitive function and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Copper Peptide AHK AHK-CuAla-His-Lys Copper Complex	Skin	C	2	Inflammation reductionSkin elasticityHair growth	Research Only	Copper Peptide AHK currently sits in Grade C with 2 estimated human studies; the strongest signals are in Inflammation reduction and Skin elasticity. Evidence base remains limited but signal-positive human evidence.	View profile →
Crystagen Thr-Glu-GlyTEG tripeptide	Immune	C	2	Inflammation reductionCardiovascular outcomes	Research Only	Crystagen currently sits in Grade C with 2 estimated human studies; the strongest signals are in Inflammation reduction and Cardiovascular outcomes. Evidence base remains limited but signal-positive human evidence.	View profile →
GHRP-1 Growth Hormone Releasing Peptide-1GPA-748	GHRP	C	2	Hormone signaling	Research Only	GHRP-1 currently sits in Grade C with 2 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Human Alpha-Defensin HNP-1Human Neutrophil Peptide-1	Immune	C	2	Inflammation reductionHormone signaling	Research Only	Human Alpha-Defensin currently sits in Grade C with 2 estimated human studies; the strongest signals are in Inflammation reduction and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Human Beta-Defensin hBD-1hBD-2	Immune	C	2	Tissue repairInflammation reductionSkin elasticity	Research Only	Human Beta-Defensin currently sits in Grade C with 2 estimated human studies; the strongest signals are in Tissue repair and Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
KE Dipeptide Lys-GluLysine-Glutamic Acid Dipeptide	Immune	C	2	Inflammation reduction	Research Only	KE Dipeptide currently sits in Grade C with 2 estimated human studies; the strongest signals are in Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Lactoferricin Lactoferricin BLfcinB	Immune	C	2	Inflammation reductionHormone signaling	Research Only	Lactoferricin currently sits in Grade C with 2 estimated human studies; the strongest signals are in Inflammation reduction and Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Leuphasyl Pentapeptide-18Tyr-D-Ala-Gly-Phe-Leu	Skin	C	2	Cognitive functionSkin elasticityHormone signaling	Research Only	Leuphasyl currently sits in Grade C with 2 estimated human studies; the strongest signals are in Cognitive function and Skin elasticity. Evidence base remains limited but signal-positive human evidence.	View profile →
Livagen Lys-Glu-Asp-AlaKEDA tetrapeptide	Longevity	C	2	Mechanistic biomarker response	Research Only	Livagen currently sits in Grade C with 2 estimated human studies; the strongest signals are in Mechanistic biomarker response. Evidence base remains limited but signal-positive human evidence.	View profile →
Melittin MELBee Venom Peptide	Immune	C	2	Weight lossInflammation reductionHormone signaling	Research Only	Melittin currently sits in Grade C with 2 estimated human studies; the strongest signals are in Weight loss and Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Myristoyl Pentapeptide-17 Eyelash Growth PeptideKeratin-Stimulating Peptide	Skin	C	2	Skin elasticityHair growth	Research Only	Myristoyl Pentapeptide-17 currently sits in Grade C with 2 estimated human studies; the strongest signals are in Skin elasticity and Hair growth. Evidence base remains limited but signal-positive human evidence.	View profile →
NGF Mimetic Peptides BB14hNGFp	Cognitive	C	2	Tissue repairCognitive functionHormone signaling	Research Only	NGF Mimetic Peptides currently sits in Grade C with 2 estimated human studies; the strongest signals are in Tissue repair and Cognitive function. Evidence base remains limited but signal-positive human evidence.	View profile →
Palmitoyl Hexapeptide-12 Biopeptide ELPal-VGVAPG	Skin	C	2	Skin elasticity	Research Only	Palmitoyl Hexapeptide-12 currently sits in Grade C with 2 estimated human studies; the strongest signals are in Skin elasticity. Evidence base remains limited but signal-positive human evidence.	View profile →
Pancragen Lys-Glu-Asp-TrpKEDW tetrapeptide	Longevity	C	2	Weight lossHbA1c reductionHormone signaling	Research Only	Pancragen currently sits in Grade C with 2 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
PEG-MGF Pegylated Mechano Growth FactorPEGylated MGF	Tissue Repair	C	2	Tissue repairLean mass	Research Only	PEG-MGF currently sits in Grade C with 2 estimated human studies; the strongest signals are in Tissue repair and Lean mass. Evidence base remains limited but signal-positive human evidence.	View profile →
Progeline Trifluoroacetyl Tripeptide-2Anti-Progerin Peptide	Skin	C	2	Skin elasticity	Research Only	Progeline currently sits in Grade C with 2 estimated human studies; the strongest signals are in Skin elasticity. Evidence base remains limited but signal-positive human evidence.	View profile →
Testagen Lys-Glu-Asp-GlyKEDG tetrapeptide	Longevity	C	2	Hormone signaling	Research Only	Testagen currently sits in Grade C with 2 estimated human studies; the strongest signals are in Hormone signaling. Evidence base remains limited but signal-positive human evidence.	View profile →
Thanatin Thanatin peptideInsect defensin (Podisus maculiventris)	Immune	C	2	Inflammation reduction	Research Only	Thanatin currently sits in Grade C with 2 estimated human studies; the strongest signals are in Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Thymosin Beta-15 Tβ15TB15	Immune	C	2	Inflammation reduction	Research Only	Thymosin Beta-15 currently sits in Grade C with 2 estimated human studies; the strongest signals are in Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Vilon Lys-GluKE dipeptide	Immune	C	2	Inflammation reduction	Research Only	Vilon currently sits in Grade C with 2 estimated human studies; the strongest signals are in Inflammation reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
MOTS-c Mitochondrial Open reading frame of the Twelve S rRNA type-cMitochondrial-Derived Peptide MOTS-c	Longevity	C	0	Weight lossHbA1c reductionHormone signaling	Preclinical	MOTS-c currently sits in Grade C with 0 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains limited but signal-positive human evidence.	View profile →
Peginesatide OmontysHematide	Hormonal	D	15	Mechanistic biomarker response	Banned	Peginesatide currently sits in Grade D with 15 estimated human studies; the strongest signals are in Mechanistic biomarker response. Evidence base remains primarily preclinical evidence.	View profile →
FGL Peptide FGLLFG loop peptide	Cognitive	E	0	Inflammation reductionCognitive functionHormone signaling	Preclinical	FGL Peptide currently sits in Grade E with 0 estimated human studies; the strongest signals are in Inflammation reduction and Cognitive function. Evidence base remains theoretical and early-stage mechanistic evidence.	View profile →
P21 P021CNTF-derived peptide	Cognitive	E	0	Cognitive function	Preclinical	P21 currently sits in Grade E with 0 estimated human studies; the strongest signals are in Cognitive function. Evidence base remains theoretical and early-stage mechanistic evidence.	View profile →
PE-22-28 Spadin analogSortilin-derived peptide	Cognitive	E	0	Cognitive functionMood/anxietyHormone signaling	Preclinical	PE-22-28 currently sits in Grade E with 0 estimated human studies; the strongest signals are in Cognitive function and Mood/anxiety. Evidence base remains theoretical and early-stage mechanistic evidence.	View profile →

Insulin

Metabolic

Insulin currently sits in Grade A with 280 estimated human studies; the strongest signals are in Weight loss and HbA1c reduction. Evidence base remains robust multi-trial human evidence.

280 human studiesApproved2015

Peptide Evidence Index

Methodology

How grades are assigned

Limitations and interpretation