Benefits
- Treats hypoactive sexual desire disorder (HSDD) in premenopausal women — statistically significant improvement in desire and distress in Phase 3 trialsstrong
- Centrally acting mechanism — works on brain pathways rather than requiring physical arousal to functionstrong
- Effective for male erectile dysfunction, including cases unresponsive to PDE5 inhibitorsmoderate
- On-demand dosing — used as needed rather than daily, providing flexibilitystrong
- May improve both desire and arousal in women, addressing multiple aspects of female sexual dysfunctionmoderate
Dosage Protocols
| Route | Dosage Range | Frequency | Notes |
|---|---|---|---|
| Subcutaneous injection (FDA-approved) | 1.75 mg | As needed, at least 45 minutes before anticipated sexual activity | Maximum 1 dose per 24 hours. FDA labeling recommends no more than 8 doses per month. |
| Subcutaneous injection (male off-label) | 1.0–2.0 mg | As needed, 1–2 hours before sexual activity | Not FDA-approved for men. Doses above 2 mg do not appear to increase efficacy but do increase nausea. |
| Intranasal (investigational) | 10–20 mg | As needed | Earlier clinical development used intranasal delivery, but bioavailability was poor and inconsistent. Subcutaneous injection is the approved route. |
Medical disclaimer
Dosage information is provided for educational reference only. Always follow your prescriber's instructions and consult a qualified healthcare provider before starting any peptide protocol.
Side Effects
- Nausea — occurs in over 40% of patients and is the most commonly reported side effect; usually subsides within hourscommon
- Facial flushing and warmth — typically begins 30–60 minutes after injection and resolves spontaneouslycommon
- Headache — reported in approximately 11% of patients in clinical trialscommon
- Injection site reactions — redness, bruising, or itching at the subcutaneous injection sitecommon
- Transient blood pressure increase — small, temporary rise in systolic and diastolic blood pressure; contraindicated in uncontrolled hypertensionrare
- Skin hyperpigmentation — darkening of skin, gums, or breasts with repeated use due to residual MC1R activityrare
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Use cases
Tools
- Reconstitution CalculatorCalculate exactly how many units to draw on your syringe. Enter your vial size, bacteriostatic water volume, and desired dose.
- Dosage CalculatorFind evidence-based dosing ranges for any peptide. Adjust for body weight, experience level, and administration route.
- Cost CalculatorEstimate peptide costs per dose, per week, per month, and per year. Enter your vial price and dosing schedule to plan your budget.
Frequently Asked Questions
How is PT-141 different from Viagra?
PT-141 and Viagra work through completely different mechanisms. Viagra (sildenafil) is a PDE5 inhibitor that increases blood flow to the genitals — it helps with the physical mechanics of erection but does not affect desire. PT-141 works in the brain by activating melanocortin-4 receptors, directly enhancing sexual desire and arousal. PT-141 can be effective in men who do not respond to Viagra, and it is the only approved drug that targets sexual desire in women.
Can men use PT-141?
Yes, though it is only FDA-approved for premenopausal women with HSDD. Clinical trials in men with erectile dysfunction showed significant improvement in erection quality and sexual satisfaction. Many clinics prescribe PT-141 off-label for men, particularly those who cannot take PDE5 inhibitors due to cardiovascular concerns or who have not responded to them.
How do you manage the nausea from PT-141?
Nausea is the most common side effect, affecting about 40% of users. Strategies to reduce it include: starting with a lower dose (0.5–1.0 mg) and titrating up, taking an anti-nausea medication (ondansetron/Zofran) 30 minutes before injecting, injecting on a partially full stomach rather than fasting, and ensuring proper hydration. Most users report that nausea diminishes with subsequent uses.
How long do the effects of PT-141 last?
While the half-life of PT-141 is approximately 2.5 hours, the pro-sexual effects typically last 6–12 hours after injection, with some users reporting residual effects up to 24–36 hours. Peak effects are generally felt 1–3 hours after subcutaneous injection. The duration varies significantly between individuals.
How much does PT-141 (Vyleesi) cost?
The branded Vyleesi auto-injector has a list price of approximately $900–$1,000 per dose without insurance, making it one of the most expensive on-demand sexual health treatments. However, compounding pharmacies offer bremelanotide at significantly lower prices, typically $30–$80 per dose with a prescription. Some telehealth clinics include it in monthly subscription plans.
References
Last updated: 2026-02-14