Benefits
- Promotes repair of injured muscles, tendons, and ligamentsstrong
- Reduces inflammation and supports immune modulationstrong
- Stimulates new blood vessel growth (angiogenesis) at injury sitesstrong
- Enhances flexibility and reduces muscle spasm and stiffnessmoderate
- Supports cardiac repair and reduces fibrosis after heart injurymoderate
- Promotes hair regrowth via stimulation of stem cells in hair folliclespreliminary
- May improve wound healing and reduce scar tissue formationmoderate
Dosage Protocols
| Route | Dosage Range | Frequency | Notes |
|---|---|---|---|
| Subcutaneous injection | 2.0–2.5 mg | 2× per week (loading), 1× per week (maintenance) | Loading phase: 2× weekly for 4–6 weeks, then reduce to maintenance |
| Intramuscular injection | 2.0–2.5 mg | 2× per week | Can inject near (not into) injury site for localized benefit |
Medical disclaimer
Dosage information is provided for educational reference only. Always follow your prescriber's instructions and consult a qualified healthcare provider before starting any peptide protocol.
Side Effects
- Injection site irritation or rednesscommon
- Temporary lethargy or fatiguecommon
- Headacherare
- Mild nausearare
- Rush of blood to the head (vasodilation effect)rare
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Frequently Asked Questions
What is the difference between TB-500 and Thymosin Beta-4?
TB-500 is a synthetic fragment of the full Thymosin Beta-4 (Tβ4) protein. It contains the active region responsible for most of Tβ4's healing properties — specifically the actin-binding domain. They are often used interchangeably in the peptide community, though TB-500 is the version typically available for research purposes.
How does TB-500 compare to BPC-157 for healing?
Both promote healing but through different mechanisms. BPC-157 works primarily through local angiogenesis and growth hormone receptor upregulation — best for localized injuries. TB-500 works systemically via actin upregulation and cell migration — better for widespread or hard-to-reach injuries. Many practitioners stack them together for synergistic healing.
How long does a typical TB-500 protocol last?
A standard protocol involves a 4–6 week loading phase (2.0–2.5 mg twice weekly), followed by a 2–4 week maintenance phase (2.0–2.5 mg once weekly). Total cycle length is typically 6–10 weeks. Improvements are usually noticed within 2–3 weeks.
Is TB-500 banned in sports?
Yes. TB-500 (Thymosin Beta-4) is banned by WADA (World Anti-Doping Agency) under the category of peptide hormones and growth factors. It is prohibited both in-competition and out-of-competition. Several athletes have received suspensions for its use.
Does TB-500 need to be injected near the injury site?
Not necessarily. Unlike some peptides, TB-500 is systemically active — it can travel through tissues to find injury sites regardless of injection location. However, some practitioners prefer injecting near the injury area for potentially faster local effects.
References
- 1Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair(2004)PubMed ↗
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Last updated: 2026-02-14