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preclinicalSexual Health

Testagen

Also known as: Lys-Glu-Asp-Gly, KEDG tetrapeptide, Testicular bioregulator

Testagen (Lys-Glu-Asp-Gly) is a synthetic tetrapeptide bioregulator targeting testicular tissue and male reproductive function. Part of Khavinson's tissue-specific peptide family, it is proposed to modulate gene expression in Leydig cells and Sertoli cells, supporting testosterone production and spermatogenesis. Preclinical studies in aged male animal models report improvements in reproductive hormone levels and testicular function markers.

2 cited references·2 researched benefits

Quick Answer

Testagen (Lys-Glu-Asp-Gly) is a synthetic tetrapeptide bioregulator targeting testicular tissue. Part of the Khavinson bioregulator family, preclinical research suggests it supports Leydig cell function and testosterone production in aging male models. It is proposed to modulate gene expression in testicular cells to maintain reproductive function. It remains a preclinical research compound without human clinical trial data or regulatory approval.

Key Facts

Mechanism
Testagen is proposed to interact with DNA regulatory regions in testicular Leydig cells (testosterone production) and Sertoli cells (spermatogenesis support). It may modulate expression of steroidogenic enzymes (CYP11A1, CYP17A1, 3β-HSD) and gonadotropin receptors (LH receptor), potentially supporting testosterone biosynthesis at the cellular level rather than through exogenous hormone replacement.
Research Status
preclinical
Half-Life
~1–2 hours (estimated)
Molecular Formula
C₁₅H₂₆N₄O₈
Primary Use
Sexual Health
Table of Contents

Benefits

  • Testosterone support — preclinical data suggests maintenance of Leydig cell function in aging modelspreliminary
  • Spermatogenesis — may support Sertoli cell function and sperm productionpreliminary

Dosage Protocols

RouteDosage RangeFrequencyNotes
Research use only10–100 mcgVariablePreclinical research compound. No approved therapeutic dosing. Not a testosterone replacement therapy.

Medical disclaimer

Dosage information is provided for educational reference only. Always follow your prescriber's instructions and consult a qualified healthcare provider before starting any peptide protocol.

Side Effects

  • No significant adverse effects reported in preclinical studiesrare

Frequently Asked Questions

Can Testagen replace testosterone replacement therapy?
No. Testagen is an experimental research compound with only preclinical animal data. It has not been shown to raise testosterone levels in humans. For male hypogonadism, FDA-approved testosterone replacement therapies (injections, gels, patches) are the established standard of care with extensive clinical evidence. Testagen should not be used as an alternative to proven medical treatments.

References

  1. 1
    Effect of testicular peptide bioregulator on reproductive function in aging(2008)
  2. 2
    Peptide bioregulators of reproductive and endocrine function(2011)PubMed ↗

Latest Research

Last updated: 2026-02-19