Stability
A peptide’s resistance to chemical degradation over time. Affected by temperature, pH, light, and oxidation. Lyophilized peptides are most stable; reconstituted peptides should be refrigerated and used within 28 days.
Frequently Asked Questions
What is Stability?
Why is Stability important in peptide research?
Related Terms
The breakdown of a peptide through chemical processes like oxidation, deamidation, or hydrolysis. Degredation reduces potency and may produce inactive or harmful byproducts. Proper storage conditions minimize degradation.
LyophilizationThe freeze-drying process that removes water from a peptide solution by sublimation under vacuum. Creates a stable, shelf-stable powder with a characteristic "puck" or "cake" appearance in the vial.
Peptide storageThe conditions required to maintain peptide stability and potency. Lyophilized peptides should be stored at -20°C for long-term or 2–8°C for short-term. Reconstituted peptides must be refrigerated and used within 28 days.
OxidationA chemical reaction that can damage methionine and cysteine residues in peptides, reducing activity. Oxidation is accelerated by light, heat, and oxygen exposure. Prevented by proper storage in amber vials with desiccant.
DeamidationA chemical degradation pathway where asparagine or glutamine residues lose their amide group. Deamidation alters peptide charge and structure, reducing biological activity. Accelerated by heat and alkaline pH.