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Pharmacology & Mechanisms

Selectivity

The ability of a peptide to preferentially bind to one receptor subtype over others. Ipamorelin is considered a selective GH secretagogue because it stimulates GH release without significantly affecting cortisol or prolactin.

Frequently Asked Questions

What is Selectivity?
The ability of a peptide to preferentially bind to one receptor subtype over others. Ipamorelin is considered a selective GH secretagogue because it stimulates GH release without significantly affecting cortisol or prolactin.
Why is Selectivity important in peptide research?
Selectivity is a key pharmacological concept that determines how peptides interact with the body. Understanding this term helps practitioners optimize dosing protocols, predict therapeutic outcomes, and minimize side effects.

Related Terms

Cross-reactivity

The ability of a peptide designed for one receptor to bind to and activate related receptors. For example, Melanotan II activates multiple melanocortin receptor subtypes, producing both tanning and sexual arousal effects.

Binding affinity

The strength of interaction between a peptide and its target receptor, typically expressed as a dissociation constant (Kd). Lower Kd values indicate stronger binding and generally higher potency.

Receptor agonist

A molecule that binds to and activates a receptor, triggering a biological response. Semaglutide is a GLP-1 receptor agonist; ipamorelin is a ghrelin receptor agonist.

Related Peptide Profiles

Ipamorelin

A selective growth hormone secretagogue that stimulates GH release through the ghrelin receptor with minimal effect on cortisol or prolactin.

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