Binding affinity
The strength of interaction between a peptide and its target receptor, typically expressed as a dissociation constant (Kd). Lower Kd values indicate stronger binding and generally higher potency.
Frequently Asked Questions
What is Binding affinity?
Why is Binding affinity important in peptide research?
Related Terms
The strength with which a peptide binds to its target receptor, described by the dissociation constant (Kd). High affinity (low Kd) typically correlates with greater potency and longer receptor occupancy.
SelectivityThe ability of a peptide to preferentially bind to one receptor subtype over others. Ipamorelin is considered a selective GH secretagogue because it stimulates GH release without significantly affecting cortisol or prolactin.
PotencyThe amount of a peptide required to produce a given effect. A more potent peptide achieves the same effect at a lower dose. Measured by EC50 — lower EC50 means higher potency.
EC50The concentration of a peptide that produces 50% of its maximum possible effect. A lower EC50 indicates greater potency. Used to compare the relative potency of different peptides acting on the same receptor.