EC50
The concentration of a peptide that produces 50% of its maximum possible effect. A lower EC50 indicates greater potency. Used to compare the relative potency of different peptides acting on the same receptor.
Frequently Asked Questions
What is EC50?
Why is EC50 important in peptide research?
Related Terms
The concentration of an inhibitor required to reduce a biological process by 50%. Used to measure the potency of peptide antagonists and enzyme inhibitors.
Dose-response curveA graph showing the relationship between peptide dose and the magnitude of biological effect. Typically S-shaped (sigmoidal), with a threshold dose, linear range, and plateau at maximum effect.
PotencyThe amount of a peptide required to produce a given effect. A more potent peptide achieves the same effect at a lower dose. Measured by EC50 — lower EC50 means higher potency.
EfficacyThe maximum therapeutic effect a peptide can produce regardless of dose. Distinct from potency — a peptide can be less potent but have greater efficacy, meaning it produces a larger maximum effect.