Dose-response curve
A graph showing the relationship between peptide dose and the magnitude of biological effect. Typically S-shaped (sigmoidal), with a threshold dose, linear range, and plateau at maximum effect.
Frequently Asked Questions
What is Dose-response curve?
Why is Dose-response curve important in peptide research?
Related Terms
The concentration of a peptide that produces 50% of its maximum possible effect. A lower EC50 indicates greater potency. Used to compare the relative potency of different peptides acting on the same receptor.
Minimum effective doseThe lowest dose of a peptide that produces a statistically significant therapeutic effect. Starting at the MED minimizes side effects while maintaining efficacy.
Maximum tolerated doseThe highest dose of a peptide that can be administered without causing unacceptable side effects. Determined in Phase 1 clinical trials through dose-escalation studies.
Therapeutic windowThe range of peptide concentrations between the minimum effective dose and the dose producing unacceptable side effects. A narrow therapeutic window requires careful dose titration and monitoring.