Racemization
The conversion of an L-amino acid to its D-enantiomer during synthesis or storage. Racemization reduces peptide activity and is a sign of degradation. Proper storage and synthesis conditions minimize this.
Frequently Asked Questions
What is Racemization?
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Related Terms
The property of a molecule that is non-superimposable on its mirror image. Natural amino acids are L-form (left-handed); D-form amino acids can be incorporated into peptides to resist enzymatic degradation.
EnantiomerOne of two mirror-image forms of a chiral molecule. L-amino acids and D-amino acids are enantiomers. D-amino acid substitutions in peptides increase protease resistance and oral bioavailability.
DegradationThe breakdown of a peptide through chemical processes like oxidation, deamidation, or hydrolysis. Degredation reduces potency and may produce inactive or harmful byproducts. Proper storage conditions minimize degradation.
StabilityA peptide’s resistance to chemical degradation over time. Affected by temperature, pH, light, and oxidation. Lyophilized peptides are most stable; reconstituted peptides should be refrigerated and used within 28 days.