AUC (area under curve)
The total drug exposure over time, calculated as the integral of the concentration-time curve. AUC reflects both the amount absorbed and the rate of elimination. Used to assess bioequivalence.
Frequently Asked Questions
What is AUC (area under curve)?
Why is AUC (area under curve) important in peptide research?
Related Terms
The maximum (peak) concentration of a peptide in the blood after administration. Cmax is influenced by dose, administration route, and absorption rate.
TmaxThe time after administration at which maximum peptide concentration (Cmax) is reached. Subcutaneous peptides typically reach Tmax in 1–4 hours.
BioequivalenceThe demonstration that two peptide products produce equivalent blood levels (Cmax and AUC within 80–125%) when administered at the same dose. Required for generic drug approval.
PharmacokineticsThe study of how the body absorbs, distributes, metabolizes, and excretes a peptide over time (what the body does to the drug). Described by parameters including Cmax, Tmax, AUC, half-life, and clearance.