Cmax
The maximum (peak) concentration of a peptide in the blood after administration. Cmax is influenced by dose, administration route, and absorption rate.
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Related Terms
The time after administration at which maximum peptide concentration (Cmax) is reached. Subcutaneous peptides typically reach Tmax in 1–4 hours.
AUC (area under curve)The total drug exposure over time, calculated as the integral of the concentration-time curve. AUC reflects both the amount absorbed and the rate of elimination. Used to assess bioequivalence.
Peak levelThe highest concentration of a peptide in the blood after administration, synonymous with Cmax. Peak levels that exceed the therapeutic window may cause dose-dependent side effects.
BioavailabilityThe fraction of an administered dose that reaches systemic circulation unchanged. Subcutaneous injection provides 65–95% bioavailability for most peptides; oral bioavailability is typically below 1% without absorption enhancers.