Trough level
The lowest concentration of a peptide in the blood, measured just before the next dose. Trough levels should remain above the minimum effective concentration for optimal therapeutic effect.
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Related Terms
The highest concentration of a peptide in the blood after administration, synonymous with Cmax. Peak levels that exceed the therapeutic window may cause dose-dependent side effects.
Steady stateThe condition where the rate of peptide administration equals the rate of elimination, resulting in consistent plasma levels. Typically reached after 4–5 half-lives of regular dosing.
Therapeutic windowThe range of peptide concentrations between the minimum effective dose and the dose producing unacceptable side effects. A narrow therapeutic window requires careful dose titration and monitoring.
Minimum effective doseThe lowest dose of a peptide that produces a statistically significant therapeutic effect. Starting at the MED minimizes side effects while maintaining efficacy.