Steady state
The condition where the rate of peptide administration equals the rate of elimination, resulting in consistent plasma levels. Typically reached after 4–5 half-lives of regular dosing.
Frequently Asked Questions
What is Steady state?
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Related Terms
The time required for the concentration of a peptide in the body to decrease by half. Determines dosing frequency — short half-life peptides (minutes) need daily dosing, while long half-life peptides (days) can be dosed weekly.
Clearance rateThe volume of blood from which a peptide is completely removed per unit time, expressed in mL/min or L/hr. Clearance determines dosing frequency along with half-life.
Trough levelThe lowest concentration of a peptide in the blood, measured just before the next dose. Trough levels should remain above the minimum effective concentration for optimal therapeutic effect.
Peak levelThe highest concentration of a peptide in the blood after administration, synonymous with Cmax. Peak levels that exceed the therapeutic window may cause dose-dependent side effects.
Maintenance doseThe ongoing dose administered after an initial loading phase to sustain therapeutic peptide levels in the body. Typically lower than the loading dose.