Tolerance
A gradual decrease in the effectiveness of a peptide with chronic use, requiring higher doses to achieve the same effect. Managed through cycling, dose adjustments, or peptide switching.
Frequently Asked Questions
What is Tolerance?
Why is Tolerance important in peptide research?
Related Terms
A rapid decrease in the response to a peptide after repeated administration within a short timeframe. More acute and pronounced than tolerance. Pulsatile dosing and cycling help prevent tachyphylaxis.
DesensitizationA rapid decrease in receptor responsiveness to a peptide agonist despite continued exposure. Distinct from downregulation — desensitization involves receptor modification rather than reduced receptor numbers.
CyclingThe practice of using a peptide for a set period (on-cycle) followed by a break (off-cycle) to maintain receptor sensitivity, reduce side effects, and prevent tolerance. Typical cycles range from 4–12 weeks on, 2–4 weeks off.
DownregulationA decrease in the number or sensitivity of receptors on a cell surface in response to prolonged agonist exposure. Downregulation reduces peptide effectiveness over time and is why cycling is recommended.