Tachyphylaxis
A rapid decrease in the response to a peptide after repeated administration within a short timeframe. More acute and pronounced than tolerance. Pulsatile dosing and cycling help prevent tachyphylaxis.
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Related Terms
A rapid decrease in receptor responsiveness to a peptide agonist despite continued exposure. Distinct from downregulation — desensitization involves receptor modification rather than reduced receptor numbers.
ToleranceA gradual decrease in the effectiveness of a peptide with chronic use, requiring higher doses to achieve the same effect. Managed through cycling, dose adjustments, or peptide switching.
CyclingThe practice of using a peptide for a set period (on-cycle) followed by a break (off-cycle) to maintain receptor sensitivity, reduce side effects, and prevent tolerance. Typical cycles range from 4–12 weeks on, 2–4 weeks off.
Pulsatile dosingA dosing strategy that mimics the body’s natural pulsatile hormone release patterns. Used with growth hormone secretagogues to prevent receptor desensitization and maintain physiological GH release.