Tertiary structure
The overall three-dimensional shape of a folded peptide or protein, determined by interactions between side chains including disulfide bonds, hydrophobic interactions, and ionic bonds.
Frequently Asked Questions
What is Tertiary structure?
Why is Tertiary structure important in peptide research?
Related Terms
Local folding patterns in a peptide chain, primarily alpha-helices and beta-sheets, stabilized by hydrogen bonds between backbone atoms. Determines how the peptide interacts with receptors.
Disulfide bondA covalent bond formed between two cysteine residues in a peptide chain. Disulfide bonds stabilize three-dimensional structure and are critical for the biological activity of many peptides including insulin.
StabilityA peptide’s resistance to chemical degradation over time. Affected by temperature, pH, light, and oxidation. Lyophilized peptides are most stable; reconstituted peptides should be refrigerated and used within 28 days.