N-terminus
The end of a peptide chain with a free amino group (-NH2). By convention, peptide sequences are written starting from the N-terminus. Modifications at the N-terminus can affect stability and half-life.
Frequently Asked Questions
What is N-terminus?
The end of a peptide chain with a free amino group (-NH2). By convention, peptide sequences are written starting from the N-terminus. Modifications at the N-terminus can affect stability and half-life.
Why is N-terminus important in peptide research?
N-terminus is a foundational concept in peptide science. Understanding peptide chemistry helps researchers and practitioners evaluate peptide quality, predict stability, and make informed decisions about storage, reconstitution, and formulation.
Related Terms
C-terminus
The end of a peptide chain with a free carboxyl group (-COOH). C-terminal modifications such as amidation can enhance peptide stability and receptor binding.
Amino acid sequenceThe specific linear order of amino acids in a peptide chain, written from N-terminus to C-terminus. The sequence determines the peptide’s three-dimensional structure and biological activity.
Primary structureThe linear sequence of amino acids in a peptide, representing the most fundamental level of structural organization. All higher-order structure and function derive from the primary sequence.