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Chemistry & Structure

Amino acid sequence

The specific linear order of amino acids in a peptide chain, written from N-terminus to C-terminus. The sequence determines the peptide’s three-dimensional structure and biological activity.

Frequently Asked Questions

What is Amino acid sequence?
The specific linear order of amino acids in a peptide chain, written from N-terminus to C-terminus. The sequence determines the peptide’s three-dimensional structure and biological activity.
Why is Amino acid sequence important in peptide research?
Amino acid sequence is a foundational concept in peptide science. Understanding peptide chemistry helps researchers and practitioners evaluate peptide quality, predict stability, and make informed decisions about storage, reconstitution, and formulation.

Related Terms

Primary structure

The linear sequence of amino acids in a peptide, representing the most fundamental level of structural organization. All higher-order structure and function derive from the primary sequence.

N-terminus

The end of a peptide chain with a free amino group (-NH2). By convention, peptide sequences are written starting from the N-terminus. Modifications at the N-terminus can affect stability and half-life.

C-terminus

The end of a peptide chain with a free carboxyl group (-COOH). C-terminal modifications such as amidation can enhance peptide stability and receptor binding.

Amino acid

An organic molecule containing both an amino group (-NH2) and a carboxyl group (-COOH). The 20 standard amino acids are the building blocks of peptides and proteins, linked together by peptide bonds.

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