Loading dose
An initial higher dose used at the start of a protocol to quickly reach therapeutic levels in the body before transitioning to a lower maintenance dose. Common with CJC-1295 with DAC and some GLP-1 agonists.
Frequently Asked Questions
What is Loading dose?
Why is Loading dose important in peptide research?
Related Terms
The ongoing dose administered after an initial loading phase to sustain therapeutic peptide levels in the body. Typically lower than the loading dose.
Saturation doseThe dose at which all available receptors are occupied and further increases produce no additional effect. Exceeding saturation dose wastes peptide and may increase side effects.
Dose titrationThe practice of gradually increasing a peptide dose over time to assess individual tolerance and find the minimum effective dose while minimizing side effects. Standard practice with GLP-1 agonists.
Steady stateThe condition where the rate of peptide administration equals the rate of elimination, resulting in consistent plasma levels. Typically reached after 4–5 half-lives of regular dosing.