Buffer solution
A solution that resists changes in pH when small amounts of acid or base are added. Peptide formulations use buffers (acetate, phosphate, histidine) to maintain the optimal pH for stability.
Frequently Asked Questions
What is Buffer solution?
Why is Buffer solution important in peptide research?
Related Terms
A measure of acidity or alkalinity on a scale of 0–14, where 7 is neutral. Most peptides are most stable at slightly acidic pH (4–6). Incorrect pH accelerates degradation through deamidation and aggregation.
ExcipientAn inactive ingredient added to a peptide formulation to improve stability, solubility, or delivery. Common excipients include mannitol (bulking agent), sucrose (cryoprotectant), and phosphate buffers.
StabilityA peptide’s resistance to chemical degradation over time. Affected by temperature, pH, light, and oxidation. Lyophilized peptides are most stable; reconstituted peptides should be refrigerated and used within 28 days.