Ziconotide Research

Wahezi S, Kaye AD, Yener U, Hunter C, George TK, Bikson M et al.

Neuromodulation is a rapidly advancing field in pain medicine, providing targeted, reversible interventions for patients with chronic pain unresponsive to conventional therapies. Advances in waveform technology, device design, and stimulation strategies have shifted neuromodulation from a last-re...

Liu S, Zhang P, Zhao Z, Li M, Jin Z, Lu A et al.

This article reviews the applications of disulfide bond-containing compounds in medicinal and agrochemical chemistry. In the medical field, disulfide bonds are crucial for stabilizing bioactive molecules like insulin and ziconotide, enhancing their efficacy. For instance, insulin analogue 1 (A10-...

Picañol J, Castellanos A, Sartori F, Gasull X, Soto D

Chronic pain remains a significant clinical challenge, especially in refractory cases. Ziconotide, a selective Cav2.2 channel blocker, offers an intrathecal approach, but concerns about its safety, potential biases, and impact on opioid consumption persist. Following Preferred Reporting Items for...

Gan H, Zhang Y, Yang C

Cheng X, Wu C

Disulfide-rich peptides (DRPs) leverage dense disulfide networks to form rigid and stable cores, enabling exceptional proteolytic resistance and precise target complementarity. These attributes drive their utility as high-affinity molecular tools in bioanalytics/chemical biology and clinically va...

Canovas Martínez L, Gago Diéguez N, Carrera Sieiro JL, López Díez R, García González C, Ortolá Más E et al.

Ziconotide and morphine are intrathecal (IT) drugs approved by the FDA and EMA for the treatment of chronic pain. The aim of this study was to determine whether opioid rescue can be achieved by gradually increasing doses of ziconotide, and to establish a practical protocol for its implementation....

Ay YA, Yurdgulu EE, Bayir Y, Halici Z

Ischemia/reperfusion (I/R) injury is a pathological condition that arises from the complex interplay of multifaceted mechanisms such as calcium imbalance, oxidative stress, mitochondrial dysfunction, and inflammatory processes. Voltage-gated calcium channels (VGCCs) play a critical role in this p...

Kim E, Han M, Jeong M, Kim S, Jeon HJ, Lee HJ et al.

Solid tumours present a significant treatment challenge owing to the poor penetration of therapeutics into the tumour core. Bacteria offer a unique solution to this problem because they can selectively target tumours and proliferate within the tumour microenvironment.In this study, we engineered ...

Kim E, Hwang DH, Mohan Prakash RL, Asirvatham RD, Lee H, Heo Y et al.

Animal venoms are complex biochemical secretions rich in highly potent and selective bioactive molecules, including peptides, enzymes, and small organic compounds. Once associated primarily with toxicity, these venoms are now recognized as a promising source of therapeutic agents for a wide range...

Mercadante S, Candido K, Staats P, Davis M

Patients with cancer pain refractory to conventional medical management may benefit from spinal analgesia, although there are some critical points regarding some aspects which cannot be examined by an evidence-based approach. A group of experts was selected by MASSC to provide clinical practice a...

Noe G, Gaba A, Munjal S

Benatti HR, Taghian T, Mihalek O, Nath S, Gallagher J, McElroy A et al.

For the treatment of central nervous system (CNS) neoplasias, achieving widespread chemotherapy distribution throughout the brain remains a major challenge. Direct infusion of substances into the cerebrospinal fluid (CSF) is one method to bypass the blood-brain barrier (BBB) and increase the expo...

Radhakrishna K, Rajshekhar PK, Arshitha R, Patil K, Dhannura S, Gowd KH et al.

The ability of AlphaFold 3 to accurately predict the 3D structure of polypeptides has been explored to investigate the oxidative folding steps of conotoxins. The peptides α-conotoxin RgIA (α-RgIA) and χ-conotoxin CMrVIA (χ-CMrVIA) share a similar cysteine pattern but diffe...

Carpenter AL, McGuire JA, Nemergut EC, Bauer KM, Navalgund YA, Scalzo DC et al.

The optimal dosing and delivery strategies for intrathecal ziconotide are debated.  Previous research suggests that high volume, low concentration dosing techniques may decrease side effects and enhance analgesic effect. Previous studies that have investigated the effects of diluting ziconot...

Wu P, Cheng Y, Wang W, Li M

Disulfide bond, an important post-translational modification in peptides or proteins, is of great significance for stabilizing the three-dimensional spatial structure of peptides and proteins, maintaining correct folding conformation, and regulating biological activity. The medicinal peptide with...

López-Carrillo J, Bernáldez-Sarabia J, Pawar TJ, Jiménez S, Dueñas S, Figueroa-Montiel A et al.

This study explores the analgesic potential of the novel conotoxin O1_cal6.4b, derived from Californiconus californicus, as a candidate for pain management in a model of inflammatory pain.O1_cal6.4b was systemically administered to Wistar rats, and its effects on thermal hyperalgesia and motor co...

Michael A, Fuller T, Brogan S, Murphy MC

Objective: We present a case of a patient with an intrathecal pump who experienced an unrecognized partial pocket fill, leading to an atypical opioid withdrawal characterized by akathisia. Case Report: A 57-year-old female with multiple myeloma presented to an emergency department with new-onset ...

Tang C, Gomez K, Chen Y, Allen HN, Hestehave S, Rodríguez-Palma EJ et al.

Antagonists - such as Ziconotide and Gabapentin - of the CaV2.2 (N-type) calcium channels are used clinically as analgesics for chronic pain. However, their use is limited by narrow therapeutic windows, difficult dosing routes (Ziconotide), misuse, and overdoses (Gabapentin), as well as a litany ...

Zlotchenko DG, Johnson DT, Kelson K

Cancer patients experience pain at significant rates but are often undertreated-it is estimated that less than 1% of eligible cancer pain patients receive appropriate targeted drug delivery to address their pain. Cancer pain is often managed with systemic opioid treatment; however, this approach ...