VIP (Vasoactive Intestinal Peptide) Research

Yang Y, Yu Q, Zhao X, Yao R, Shen J, Jiang S et al.

Patients' illness experiences and needs are central to pulmonary tuberculosis management and have important implications for treatment engagement and health outcomes. This study addresses this gap by systematically synthesizing qualitative evidence to provide a comprehensive understanding of pulm...

Yu J, Fu J, Zhao S, Zhang S, Huang R, Li T et al.

Emotional symptoms, particularly anxiety and depression, are common in COPD patients but are often under-managed. This study aimed to synthesize evidence on non-pharmacological interventions for these symptoms in COPD. An umbrella review of guidelines, systematic reviews, and expert consensus was...

Sheng D, Meng Y, An S, Wu Z, Yao J, Huang Y et al.

The objective of this investigation was to examine the histopathological alterations in the rat hippocampus induced by myofascial trigger points (MTrPs), assess hippocampal neuronal excitability by measuring c-fos protein expression, and Non-targeted metabolomics was employed to profile hippocamp...

Xu M, Gu Y, Wang F, Zhu C, Xu Q, Kan J et al.

This study investigated the effects of three thermal processing methods (microwave, MW; sous-vide, SV; and air frying, AF) on the texture, color, volatile, and nonvolatile components of three lotus root varieties (Zaohua, SW, and E9:11). The results indicated that SV effectively preserved texture...

Ding M, Wang M, Gao M, Zou J, Li L, Chen J et al.

This study aims to determine the efficacy of digital psychological interventions for specific psychological outcomes, including depression, anxiety, stress, insomnia, fatigue, and quality of life in patients with cardiovascular disease.Randomized controlled trials evaluating digital psychological...

Jiang X, Chen C, Zhao M, Hu L, Shi L, Tang T et al.

Maternally inherited, high-copy, non-recombining and fast-mutating, mitochondrial DNA (mtDNA) is exploited in anthropology to trace maternal ancestry and in genetics to reconstruct population histories and study disease susceptibility. The Han Chinese represent the largest ethnic group in the nat...

Liu Y, Carrero ZI, Jiang X, Ferber D, Wölflein G, Zhang L et al.

Agentic artificial intelligence (AI) systems, designed to autonomously reason, plan, and invoke tools, have shown promise in healthcare, yet systematic benchmarking of their real-world performance remains limited. In this study, we evaluate two such systems: the open-source OpenManus, built on Me...

Wysolmerski B, Fisher NM, Dates AN, Inoue A, Blythe EE, von Zastrow M et al.

Many GPCRs trigger a second phase of G protein-coupled signaling from endosomes after signaling from the plasma membrane, necessitating GPCRs to increase the concentration of active-state G proteins on the endosome membrane. How this is achieved remains unclear. Here, we show that three Gs-couple...

Sun H, Yu Z, Piao C, Gu J, Geng F, Ai H et al.

Ulcerative colitis (UC) involves barrier disruption, dysbiosis, and altered host-microbe metabolism. Zuojin Wan (ZJW) benefits gastrointestinal disorders, but its systems-level mechanisms in UC are unclear.In DSS-induced UC mice, ZJW chemistry was profiled by HPLC-MS, and efficacy was assessed by...

Zeng X, Xie H, Zhang W, Yu Y, Wang M, Jiang Y et al.

PINK1 and Parkin are central regulators of mitophagy, a quality-control process essential for mitochondrial homeostasis and implicated in aging. However, their specific roles in ovarian physiology remain unclear. Here, we show that Pink1 deletion in mice leads to decreased ovarian weight, diminis...

Mao M, Zhu J, Wenren Z, Sun Y, Xia Q, Pan D et al.

This study investigated changes in protein degradation and taste compounds during the roasting process of air-dried beef. Results indicated that roasting significantly accelerated protein degradation, with the protein hydrolysis index rising from 6.76% to 17.77% - an increase of approximately 2.6...

Lin W, Wang C, Hu Q, You D, Chen B, Li D et al.

Introduction Cerebral Small Vessel Disease (CSVD) is a leading cause of vascular cognitive impairment, and CSVD-related cognitive impairment (CSVD-VCI) heavily burdens individuals, families, and society amid population aging. Current CSVD-VCI treatments only control vascular risk factors and mana...

Fang Z, Liu Z, Pu Z, Xia Q, Zhang Q, Wang L et al.

Numerous risk-prediction models for hepatic encephalopathy (HE) after TIPS have been proposed, but their quality, discrimination, and clinical utility remain uncertain. We aimed to identify key predictors of post-TIPS HE and to critically appraise existing models.We performed a systematic review ...

He TT, Jiao TQ, An XM

The number of risk prediction models for sepsis-associated encephalopathy (SAE) is increasing, while the quality and applicability of these models in clinical practice and future research remain uncertain.To systematically review published studies on SAE risk prediction models.Systematic review a...

Guo Z, Xu C, Zhang S, Hao Y, Hu X, Zhao M et al.

As an emerging biomarker, tumor mutational burden (TMB) has attracted increasing attention from clinicians in predicting the efficacy of tumor immunotherapy. Currently, TMB is detected primarily by whole-exome sequencing or targeted panel sequencing on high-throughput sequencing platforms. Howeve...

Chen Z, Liu Q, Feng H, Zhang X, Luo L, Chen P et al.

Plant-derived exosome-like nanovesicles (PELNs) represent natural nanocarriers for advanced nutrient delivery, with their lipid being a underutilized resource. However, a question is whether geographical variation of plant alters the lipid composition of PELNs to impact immune cells. To investiga...

Tian Y, Du Y, Yang Q, Zhao C, Zhang F, Zhang S et al.

To address health risks of traditional high-salt Doubanjiang, reduced-salt fermentation has been adopted, often accompanied by enrichment of specific lactic acid bacteria (LAB) including Ligilactobacillus, Tetragenococcus and Levilactobacillus. Nevertheless, their key roles and potential molecula...

Wei X, Zhuo C, Hicks JP, Zhang Z, Wu S, Walley JD et al.

Antimicrobial resistance is driven by inappropriate use of antibiotics for acute respiratory infections (ARIs), which is a major challenge in primary care in low- and middle-income countries. Here we conducted a pragmatic, cluster randomized controlled trial in 34 township hospitals in two rural ...

Chen H, Feng S, Wang Y, Zhong L, Liang W, Shi K et al.

The electrolytes of aqueous batteries are mostly acidic or alkaline, resulting in inevitable side reactions. More importantly, when batteries are disposed of, strongly acidic and alkaline solutions harm the environment. In this study, we synthesized covalent organic polymers as negative electrode...

Xu X, Zhao S, Guo Y

This study aimed to evaluate the clinical presentation and imaging characteristics of atypical retroperitoneal paragangliomas using contrast-enhanced computed tomography (CECT), and ultrasonography (US). Additionally, the study sought to identify imaging features that facilitate early and accurat...