Vasopressin Research

Ari H, Tütüncü A, Ari S, Balyimez AD, Bozat T

Percutaneous mitral paravalvular leak (PVL) closure in patients with double mechanical valves presents substantial technical challenges when conventional transseptal antegrade approaches fail. Transapical puncture, while an alternative, carries significant risks including hemothorax and coronary ...

Hu YJ, Diao N, Liang D

Nine undescribed compounds, including two sesquiterpenoid-substituted flavanols (1 and 2), a flavan glucoside (3), and three pairs of lignan enantiomers (4a/4b‒6a/6b), together with 22 known flavonoid derivatives (7a/7b and 8‒27) were isolated from an EtOH extract of the rattans of ...

Sharma J

Enuresis, also known as nocturnal enuresis or bedwetting, refers to intermittent incontinence during sleep. It warrants medical attention, in children older than five years of age, or earlier if desired by the child or family, due to its significant emotional and psychological impact on quality o...

Tang Y, Chen Y, Qi P, Li R, Jiang W, Sun H et al.

Nicotinamide adenine dinucleotide (NAD+) is a key coenzyme for human redox reactions, vital for cellular health and metabolic balance. Lots of NAD+-dependent redox enzymes, like alcohol dehydrogenase (ADH) and lactate dehydrogenase, can catalyze both forward and reverse reactions. However, substr...

Roldão M, Soares Dionísio A, Duarte J, Salgadinho Machado A, Anastácio M

Acute hepatic porphyrias (AHPs) are rare metabolic disorders of heme biosynthesis that present with neurovisceral symptoms such as abdominal pain, vomiting, and hyponatremia. Diagnosis is frequently delayed due to the nonspecific nature of the symptoms and insufficient awareness of the disease. A...

Yap C, Warner R, Hoefnagel AL, Shah S, Mongan PD, Awad Z et al.

Anastomotic leak (AL) is a significant complication after esophagectomy, occurring in 9-11% of cases, increasing morbidity and resource utilization. This study evaluated perioperative, surgical, and hemodynamic factors associated with AL after Ivor Lewis esophagectomy.We conducted a retrospective...

Kashimura Y, Hara K, Shiojima H, Oki M, Ueno K

Anaphylaxis in patients taking antihypertensive medications is a life-threatening condition. Early recognition and intervention are crucial to reducing mortality, especially when severe organ dysfunction, such as a central nervous system (CNS) disorder, is present. A 69-year-old male patient with...

Melchers M, Pickkers P, van Zanten ARH

Obesity is increasingly prevalent in ICU patients, often requiring adjusted dosing due to altered drug pharmacodynamics. Arginine vasopressin (AVP) is used adjunctively to norepinephrine (NE) in septic shock, but its hemodynamic efficacy may vary with body mass index (BMI), potentially influencin...

Mikulić S, Kraljević D, Damjanović A, Prskalo M

Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis in infancy and the most frequent reason for hospitalization in the first months of life. While most infections follow a mild course, a proportion of infants develop severe disease requiring intensive care. Electrolyte disturb...

Komeyama S, Seguchi O, Mochizuki H, Tadokoro N, Watanabe T, Iwai S et al.

The treatment of patients with biventricular heart failure using a left ventricular assist device (LVAD) remains a significant challenge. For patients with cardiac arrest (CA), biventricular assist device (BiVAD) support is necessary; however, it severely impacts their quality of life. We present...

Mallinson PA, Birk N, Henderson AD, Lewin A, Shah AS, Mehrkar A et al.

Long COVID continues to affect millions of adults and contribute to substantial economic burden across Europe. Ethnic inequalities in Long COVID, and the reasons underlying these, are poorly understood. We aimed to investigate ethnic differences in the incidence of diagnosed Long COVID in England...

Jiang Z, Qu X, Yan Z, Fang J, Lan J, Zhao X et al.

Escitalopram is widely regarded as a well-tolerated selective serotonin reuptake inhibitor (SSRI) with a favorable safety profile. However, severe adverse events can occur even at therapeutic doses in susceptible individuals. Here, we report a rare case of simultaneous life-threatening Syndrome o...

Verbalis JG

Hyponatremia is the most frequently encountered electrolyte disorder in clinical practice. Understanding the pathophysiology of the many different etiologies of hyponatremia is essential for appropriate diagnosis and therapy of hyponatremic disorders. Hyponatremia can occur by an increase in tota...

de Oliveira GA, Gomes PM

Wang Y, Guo J, Dong Y, Zhu J, Fang S, Wu Y et al.

This randomized, double-blind, placebo-controlled clinical trial investigated the effects of Weizmannia coagulans BC99 on alcohol-related physiological disturbances in adults with chronic alcohol consumers. Sixty participants were randomly assigned to receive either BC99 or placebo for 60 days. C...

Nguyen NX, Vo TKT, Le HTT, Tran QV, Tran HNT, Pham NT et al.

Hyponatraemia is the most common electrolyte disorder and a recognised precipitant of acute symptomatic seizures. In addition to drug-induced, endocrine, and central nervous system causes, acute psychological stress can provoke non-osmotic AVP secretion with inappropriate antidiuresis (SIAD-like ...

Shu T, Zeng X, Wang J, Jiang H, Wang Y, Zhang M et al.

Alcoholic liver disease (ALD) remains a significant clinical challenge with limited therapeutics. It is strongly associated with sarcopenia, which further worsens the prognosis in liver cirrhosis. Zinc-deficiency is a hallmark of ALD, impairing the liver's antioxidant defenses and alcohol metabol...

Bie P

Xie X, Li H, Chang Y, Ji M, Wang M, Hu J et al.

Depression represents a leading cause of global disability, yet its pathogenesis remains incompletely understood. This review synthesizes emerging evidence highlighting the multifaceted role of Aquaporin-4 (AQP4), the central nervous system's predominant water channel, in the pathophysiology of d...

Zhu J, Qin W, Wu B, Li H, Cheng C, Han X et al.

Chronic diabetic wounds, particularly diabetic foot ulcers (DFUs), are prone to recurrent infection and delayed healing, resulting in substantial morbidity, mortality, and economic burden. Multifunctional wound dressings that combine antibacterial, antioxidant, conductive, and self-healing proper...