Uroguanylin Research

Akram U, Ul Ain H, Ahmed S, Fatima E, Raza MA, Ahmad E et al.

Constipation is a common gastrointestinal disorder with limited effective treatments and a significant impact on quality of life. Plecanatide, a guanylate cyclase-C agonist, has shown promise in improving symptoms with a favorable safety profile. This meta-analysis aimed to evaluate the effective...

Matsuda N, Yoshida Y, Gotoh K, Nagai S, Kurimoto R, Sada K et al.

Background/Objectives: Sleeve gastrectomy (SG) is the most commonly performed bariatric surgery worldwide. It results in significant weight loss and improves metabolic disorders such as hypertension. Weight loss is thought to be the main factor contributing to blood pressure (BP) reduction after ...

Xiu R, Reiner J, Hofmann F, Salari A, Seidler U

Guanylate cyclase-C (GC-C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy. The present...

Wong CH, Leung DK, Ko IC, Siu B, Yuan Y, Teoh JY et al.

Radical nephroureterectomy is the standard of care for management of upper tract urothelial carcinoma (UTUC), but treatment-associated morbidity is not uncommon. Intracavitary therapy has emerged as a less invasive alternative for selected cases, particularly carcinoma in situ (CIS) and low-grade...

Peyton CC, Kates M, Nadkarni A, Dhanda R, Ugwuoke N, Tsurutis V et al.

UGN-102 is a reverse thermal hydrogel formulation of mitomycin indicated for nonsurgical intravesical treatment of recurrent low-grade intermediate-risk nonmuscle-invasive bladder cancer (LG-IR-NMIBC). This analysis evaluates patient-reported outcomes (PROs) for quality of life (QoL), functioning...

Prasad SM, Louie MJ, Burger B, Tsurutis V, Ugwuoke N, Strauss-Ayali D et al.

To evaluate the pharmacokinetic properties of UGN-102, a mitomycin-containing reverse thermal gel.Twelve patients with NMIBC received 6 once-weekly intravesical instillations of UGN-102 (BL004: 120 mg mitomycin [n = 6]; BL005: 75 mg mitomycin [n = 6]). Plasma...

Snigireva ED, Smirnova OV

Guanylins are intestinal natriuretic peptides that regulate water and electrolyte balance in the intestine and kidney. Their primary receptor is membrane guanylyl cyclase C (GC-C), while alternative functions related to feeding behavior and olfactory preferences are mediated by guanylyl cyclase D...

Bünning KT, Morgen P, Forano C, Prevot V, Selent A, Telkki VV et al.

Monolithic layered double hydroxides (LDH) may alleviate the challenging separation process after ion-exchange of conventionally polycrystalline (powdery) LDH, which have been extensively tested as potential phosphate sorbents. However, the structure, ion-exchange properties, and stability of mon...

Dos Reis DC, Jin J, Santos A, Dastoor P, Muiler C, Zagoren E et al.

Single-cell RNA sequencing (scRNA-Seq) studies identified a novel subpopulation of epithelial cells along the rostrocaudal axis of human intestine, specifically marked by bestrophin 4 (BEST4), that are enriched for genes regulating pH, GPCR acid-sensing receptors, satiety, cGMP signaling, [Formul...

Guit M, Tanida K, Degel-Brossmann N, Christner M, Aepfelbacher M, Rohde H et al.

Gram-negative bloodstream infections (GN-BSI) significantly impact hospital admissions, presenting major health challenges. Despite guidelines advocating de-escalation, oralization, and appropriate treatment durations, real-world clinical management remains unclear.This retrospective observationa...

Yu H, Li J, Lu T, Dai M, Wan X

NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome plays a pivotal role in the progression of cerebral ischemia/reperfusion injury (CI/RI). We aimed to investigate the implication of WW domain-containing protein 2 (WWP2), an E3 ubiquitin ligase, in CI/RI and its mechanism. Micr...

Shore ND, Chevli KK, Saltzstein D, Ehrlich Y, Raman JD, Friedman B et al.

The OPTIMA II phase 2b study (NCT03558503) treated patients with low-grade intermediate-risk non-muscle invasive bladder cancer (LG-IR-NMIBC) with UGN-102, a reverse thermal hydrogel containing mitomycin. Efficacy and safety results have been reported for the 12-month parent study; here, we repor...

Uleri A, Katzendorn O, Khene ZE, Xylinas E, Ramos FG, Pradere B et al.

Nonmuscle invasive bladder cancer (NMIBC) represents approximately 75% of bladder cancer cases at diagnosis and poses a significant management challenge due to high recurrence rates and risk for progression. Conventional intravesical therapies face limitations including suboptimal drug delivery, ...

Zhou Y, Jin J, Zhou P, Su W, Yao G

The principle of structure dictating properties is illustrated by the direct correlation between cyclic peptide conformation and their biological efficacy. Plecanatide, a synthetic analog of uroguanylin, has received FDA approval for the treatment of chronic idiopathic constipation and irritable ...

Yao Y, Yang G, Jiang S, Ji B, Jin H, Tang P et al.

Various conservative and surgical treatments was clinically applied in rotator cuff calcific tendinitis (RCCT), the evaluation of distinction among all available intervention is still lacking. This study aims to systematically compare the efficacy and safety of these interventions and provide gui...

Bai T, Xu Z, Zhen Y, Liao A, Wang B, Zhao R et al.

Plecanatide is a novel guanylate cyclase-C agonist for the treatment of functional constipation (FC). Its efficacy may vary across different racial populations.This study aimed to comprehensively evaluate the efficacy, safety, and pharmacokinetics of plecanatide in Chinese patients with FC.This p...

Habek N, Ratko M, Sedmak D, Banovac I, Crljen V, Kordić M et al.

Preclinical and clinical research of insulin resistance and glucose homeostasis in metabolic disorders are essential. In this study, we aim to determine the expression of uroguanylin (UGN) in the mouse and human brain, its regulatory mechanisms, and its significance to patients with obesity and t...

Hemo O, Hasdai T, Hendel H, Shvero A, Kleinmann N, Lifshitz D et al.

Upper tract urothelial carcinoma (UTUC) is a rare yet aggressive malignancy, representing 5-10% of urothelial cancers. While radical nephroureterectomy (RNU) has traditionally offered excellent oncological control, it compromises renal function. Recent advancements have shifted the paradigm towar...

Heo B, Linh VTN, Yang JY, Park R, Park SG, Nam MK et al.

Osteoarthritis (OA) and rheumatoid arthritis (RA) are major causes of functional impairment, disability, and chronic pain, leading to a substantial rise in healthcare costs. Despite differences in pathophysiology, these diseases share overlapping features that complicate diagnosis, necessitating ...

Stover AM, Mueller D, Carda-Auten J, Hilton A, Tsurutis V, Smith AB et al.

Adults with low-grade intermediate-risk nonmuscle-invasive bladder cancer commonly ask urologists how their routine/responsibilities will be affected by treatments, including the standard of care, transurethral resection of bladder tumor (TURBT). We asked patients in the ENVISION trial to compare...