Ularitide Research

Novack ML, Zubair M

Natriuretic peptides are key proteins that improve and regulate circulation. These proteins are essential for acting on blood vessels, causing them to widen or dilate. Natriuretic peptides are expressed predominantly by cardiomyocytes of the mixed secretory-contractile phenotype in atrial an...

Lin H, Bousnina K, Slagter JS, Fang Y, Cristoferi I, Garrelds IM et al.

Human donor kidneys release (pro)renin, erythropoietin (EPO), active vitamin D, and urodilatin during normothermic machine perfusion (NMP). However, whether the endocrine function of donor kidneys is associated with post-transplant kidney function is unclear.We studied 28 donor kidneys, including...

Gantzel RH, Møller EE, Aagaard NK, Watson H, Jepsen P, Grønbæk H et al.

Sodium and water retention is a mainstay of the pathophysiology leading to ascites formation in patients with advanced cirrhosis. Refractory ascites denotes the most severe ascites status with limited treatment options and a poor prognosis. We investigated the efficacy and safety of the natriuret...

Haryani A, Sangwan A

Heart failure (HF) is a syndrome characterized by the heart failing to pump blood to the body at a rate proportional to its needs. HF is a public health burden globally and one of the leading causes of hospitalizations in adults. While many classes of drugs have been introduced for the treat...

Lin H, Du Z, Bouari S, Rijkse E, Cristoferi I, Obser A et al.

Normothermic machine perfusion (NMP) is an alternative to hypothermic machine perfusion (HMP) for donor kidney preservation before transplantation. Contrary to HMP, NMP allows for functional assessment of donor kidneys because normothermic conditions allow for metabolic activity. The kidneys are ...

Della Corte V, Pacinella G, Todaro F, Pecoraro R, Tuttolomondo A

In the modern scientific landscape, natriuretic peptides are a complex and interesting network of molecules playing pleiotropic effects on many organs and tissues, ensuring the maintenance of homeostasis mainly in the cardiovascular system and regulating the water-salt balance. The characterizati...

Dai H, Li H, Wang B, Zhang J, Chen Y, Zhang X et al.

Background: A network meta-analysis (NMA) of the current recommended drugs for the treatment of acute heart failure (AHF), was performed to compare the relative efficacy. Methods: We used PubMed, EMBASE, Cochrane Clinical Trials Register, and Web of Science systems to search studies of randomized...

Gantzel RH, Kjær MB, Jepsen P, Aagaard NK, Watson H, Gluud LL et al.

Natriuretic peptides are involved in the cascade of pathophysiological events occurring in liver cirrhosis, counterbalancing vasoconstriction and anti-natriuretic factors. The effects of natriuretic peptides as treatment of cirrhotic ascites have been investigated only in small studies, and defin...

Gantzel RH, Meyer M, Mazgareanu S, Aagaard NK, Jepsen P, Holzmeister J et al.

INTRODUCTION Ascites is a frequent complication to cirrhosis. When ascites becomes refractory to standard diuretic pharmacotherapy, patients are facing a median survival of less than one year and most likely a need for frequent hospitalisations due to large-volume paracentesis or complications. A...

Xu M, Liu X, Li P, Yang Y, Zhang W, Zhao S et al.

The natriuretic peptide family (NPs) is a group of natural endocrine hormones, containing a 17-amino acid ring structure connected by disulfide bonds of two cysteines. In this review, the members of the natriuretic peptide family and their corresponding receptors as well as the anti-cancer effect...

Romańczyk M, Surma S, Łabuzek K

Natriuretic peptides are peptide hormones which are involved in the regulation of blood pressure, water-mineral balance and multiple metabolic processes. The beginning of research on this group of hormones starts in 1981, when the deBold and collaborators discovered ANP. Eight natriuretic peptide...

Pollesello P, Ben Gal T, Bettex D, Cerny V, Comin-Colet J, Eremenko AA et al.

Both acute and advanced heart failure are an increasing threat in term of survival, quality of life and socio-economical burdens. Paradoxically, the use of successful treatments for chronic heart failure can prolong life but-per definition-causes the rise in age of patients experiencing acute dec...

Machaj F, Dembowska E, Rosik J, Szostak B, Mazurek-Mochol M, Pawlik A et al.

Despite continuous efforts to prevent cardiovascular diseases (CVDs), heart failure prevails as the number one cause of death in developed countries. To properly treat CVDs, scientists had to take a closer look at the factors that contribute to their pathogenesis and either modernize current phar...

Gouda P, Ezekowitz JA

To highlight the advances in the diagnosis and management of acute heart failure (AHF) from recent clinical trials and observational studies.We highlight date from recent studies examining the use of novel biomarkers (micro RNAs, osteopontin, insulin-like growth-factor binding protein-7) for the ...

Mitrovic V, Forssmann WG, Schnitker J, Felix SB

Acute decompensated heart failure (ADHF) has a poor prognosis and limited treatment options. No direct comparisons between ularitide-a synthetic natriuretic peptide being evaluated in ADHF-and other vasoactive substances are available. The aim of this meta-analysis was to determine haemodynamic e...

Yandrapalli S, Jolly G, Biswas M, Rochlani Y, Harikrishnan P, Aronow WS et al.

Heart failure (HF) is characterized by maladaptive neurohormonal activation of the cardiovascular and renal systems resulting in circulatory inadequacy and frequent acute exacerbations. The increasing burden of HF prompted investigation of underlying pathophysiological mechanisms and the design o...

Chen Y, Burnett JC

The particulate guanylyl cyclase A (pGC-A)/cGMP pathway plays important roles in regulating renal physiological function and as well as in counteracting pathophysiological conditions. Naturally occurring peptide pGC-A activators consist of atrial natriuretic peptide (ANP), b-type NP (BNP), and ur...

Benomar K, Espiard S, Loyer C, Jannin A, Vantyghem MC

Natriuretic peptides are a group of hormones including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C type (CNP), urodilatin and guanilyn. ANP (half-life: 2-4 min), is secreted by the atrium, BNP (half-life: 20 min) by the ventricle, CNP by the vascular endothelium, urodilat...

Travessa AM, Menezes Falcão L

Acute heart failure (AHF) contributes largely to the worldwide burden of heart failure (HF) and is associated with high mortality, poor prognosis and high rehospitalization rate. The pharmacologic therapy of AHF includes diuretics and vasodilators, which are a keystone when fluid overload and con...