Triptorelin Research

Tran B, Yeh N, Gayle A, Holmes E, Hu J, Damineni S et al.

An understanding of how androgen deprivation therapy (ADT) prescribing patterns impact patient outcomes in a real-world setting is needed to help inform treatment decisions and improve the care of patients with prostate cancer (PCa). REASSURE was a retrospective, observational study that describe...

Zhao AM, Wang Y, Yang WW, Liang ZQ, Shen FJ, Li CZ et al.

Objective: To evaluate the efficacy and safety of triptorelin acetate microspheres for injection compared with triptorelin acetate for injection in the treatment of endometriosis. Methods: A total of 392 patients with endometriosis were prospectively enrolled from 47 research centers across China...

Li J, Lv X, Jiang Y

The aim of this study was to investigate the mechanism of action of SB on TRP-induced abnormalities of bone metabolism in LNCaP cells.The effects of different concentrations of SB and TRP alone and in combination on the proliferation of LNCaP cells were examined by CCK-8 assay, and the half maxim...

Foreman A, Klein KO, Vargas Trujillo M

Gonadotropin-releasing hormone agonists are used to suppress physical signs of puberty and improve height outcomes by decelerating bone age maturation in patients with central precocious puberty (CPP). Published data assessing biochemical and clinical parameters in patients with CPP treated with ...

Cui B, Liu Y, Wu X, Li X

The objective of this study was to evaluate the effects of exogenous GnRH administration at the beginning of estrus synchronisation in mares during the spring transitional period. Estrus was synchronised using a progesterone releasing intravaginal device (PRID). The PRID was left in the vagina fo...

Sperber JL, Nuttelman B, MacDonald J

Across decades of research, implants consistently improve growth: suckling calves gain roughly 6% to 15% more ADG and wean about 10.4 kg heavier, while backgrounded cattle commonly realize 14% to 16% greater ADG. Administering a single calfhood implant to a replacement heifer within the recommend...

Sandhu K, Wells C, Newton MMH, Murphy DG, Lawrentschuk N, Perera ML et al.

Androgen deprivation therapy (ADT) has been pivotal in advanced prostate cancer (PCa) for decades. The introduction of androgen-receptor pathway inhibitors (ARPIs) has transformed treatment paradigms. However, their real-world adoption over time has not been comprehensively characterised. We exam...

Ferdowsi GS, Jafarian M, Ramezanpour S, Aghamirza Moghim Aliabadi H

Hydrogen is a green energy carrier with high energy density. Its production and storage are facing challenges that have made researchers use different materials for its production and storage. Peptides are known to be very effective as the framework of metal cores for making electrocatalysts. The...

Chioma L, Bizzarri C, Longobardi M, Mainieri F, Porzio O, D'Agostini M et al.

Central precocious puberty (CPP) results from premature activation of the hypothalamic-pituitary-gonadal axis. The GnRH stimulation test remains the diagnostic gold standard, especially in girls with undetectable basal LH levels. However, native GnRH is expensive and often unavailable. Rapid-acti...

Mathieu d'Argent E, Guivarc'h-Leveque A, Catteau-Jonard S, Cedrin-Durnerin I, Peigné M, Jung C et al.

We aimed to assess the impact of the timing of ovarian stimulation initiation on the number of oocytes retrieved in a progestin-primed ovarian stimulation (PPOS) protocol for oocyte donors.A total of 110 oocyte donors were randomized in a multicenter, open-label, pilot randomized controlled trial...

Greiner H, Packeiser EM, Körber H, Stempel S, Freise F, Goericke-Pesch S et al.

Deslorelin slow-release implants (DSRI) reversibly suppresses testicular function in dogs, although the effects on the epididymis remain poorly investigated. As prostaglandins E2 and D2 contribute to epididymal function, presumably regulated by androgens, corresponding metabolic enzymes and recep...

Cao Z, Cheng J, Chen Z, Lei X, Yang L, Zhan M et al.

Although triptorelin acetate (TA) is generally considered a safe medication, severe adverse drug reactions (ADRs) to triptorelin have occurred. In this study, we present the largest retrospective analysis of ADRs related to TA during the treatment of pediatric central precocious puberty.We descri...

Sodero G

Central precocious puberty (CPP) is diagnosed through a combination of clinical, auxological, and biochemical parameters, with pharmacological stimulation tests considered the diagnostic gold standard. In recent years, triptorelin, a long-acting Gonadotropin-Releasing Hormone (GnRH) analog, has b...

Lacasella G, Volonnino G, Salducci M, Ottavian M, Spadazzi F, Karaboue MAA et al.

Triptorelin, a GnRH analogue, is used as a puberty blocker for transgender and gender-diverse adolescents experiencing gender dysphoria (GD). This treatment allows these individuals to delay puberty, offering time to explore their gender identity. Despite its recognized benefits in alleviating ps...

Friedrich NA, Janes JL, Parrish J, De Hoedt AM, Josan K, Tatonetti NP et al.

Androgen deprivation therapy (ADT) for prostate cancer (PC) has been linked to adverse events, such as cardiac events and osteoporosis. Whether these associations differ by race is unknown.To assess the association between ADT and time to cardiovascular and bone-related adverse events across raci...

Wilkinson JF, Williams PL, Green JC, Modi S, Briggs PE

This is a case report of a 47-year-old woman with known Long QT Syndrome who was given GnRH analogues to induce menopause prior to hysterectomy for fibroids who suffered several episodes of ventricular fibrillation leading to Torsades de Pointes cardiac arrests. This paper discusses the case and ...

Seo JH, Yoo MJ, Lee K, Choi J, Choe Y, Yang S et al.

Zhou Y, Liu X, Yang X, Yu Y, Zhou Y, Zhou H et al.

To expound the efficacy of Huayu Xiaozheng Decoction (HYXZD) combined with triptorelin and mifepristone in the treatment of uterine fibroids, with a particular focus on its effect on uterine artery hemodynamics.A total of 102 women with uterine fibroids were enrolled and randomly allocated into a...

Lebret T, Crehange G, Pello-Leprince-Ringuet N, Perrot V, Rigaud J

Data on modalities of real-world use of androgen deprivation therapy, such as triptorelin, in men with prostate cancer (PCa) are lacking.To describe the real-world management of triptorelin treatment over 12 months following treatment initiation in France, and to gain a better understandin...

Zeng B, Zhou Y, Jia R, Kong FS, Huang P, Chen M et al.

There are different opinions about the effect of body mass index on gonadotropin-releasing hormone stimulation tests in the laboratory diagnosis of precocious puberty in girls. The blood collection of precocious puberty girls with overweight or obesity is more difficult than those with normal bod...