Thymulin Research

Liu Z, Kim S, Cho H

In biomedical research, understanding the dynamic relationships between two binary variables over time is crucial. Our study enhances this understanding by employing longitudinal analysis to introduce measures such as the bivariate time-varying odds ratio and relative risk. These metrics adeptly ...

Alsarayreh M, Farber MA, Parodi FE

Fenestrated endovascular repair (FEVAR) has become a safe and effective option for the treatment of complex aortic aneurysms (CAA). Complications can occur, including endoleaks like type IIIc endoleak, characterized by flow between a fenestration and its bridging stent. Although some endoleaks ma...

Zühlke MK, Bahr A, Bartosik D, Solanki V, Teune M, Welsch N et al.

Fructans are ubiquitous in terrestrial ecosystems, however, these glycans are underexplored in the marine environment. We have discovered that the Antarctic gammaproteobacterium Pseudoalteromonas distincta is highly adapted to the degradation of fructose-containing substrates. This is enabled by ...

Jones E, Casey A, MacArthur C, Coleman T, Jankovic J, Taylor B et al.

Pregnant women who use specialist perinatal mental health services are more likely to be smokers at the time of birth than those without mental illness. This study explored health professionals' experiences of providing smoking cessation support to pregnant women with complex and severe mental il...

Maziak A, Heidorn-Czarna M, Gehl-Väisänen B, Kaźmierczak U, Jańska H

The FTSH4 protease is a major component of the Arabidopsis mitochondrial protein quality control system. It has both a proteolytic and a chaperone-like activity and forms complexes anchored in the inner mitochondrial membrane. Here, we show that FTSH4 assembles into two distinct forms: a dominant...

Dong J, Xiao X, Nong L, Xue X, Wang L, Sun X et al.

Angioimmunoblastic T-cell lymphoma (AITL) exemplifies a neoplasm characterized by prominent inflammatory infiltration and robust immune responses in the tumor microenvironment (TME). The pathophysiology of refractory/recurrent (RR) AITL remains poorly understood due to profound intratumoral heter...

Beauvais M, Schatt P, Soulié T, Lambert S, Montiel L, Gaudin M et al.

Marine microbial communities are fundamental to nutrient and biogeochemical cycling, with intricate networks of metabolic interdependencies influencing their structure and dynamics. Among these, vitamins B1 (thiamin) and B12 (cobalamin) play crucial roles as enzymatic cofactors in central metabol...

Akiyama M, Tanaka N, Osterloh WR, Higashi M, Sotome H, Yamakata A et al.

A phenothiazine (PTZ)-zincporphyrin (ZnP)-naphthalenediimide (NDI) triad was designed and synthesized to address the effects of electronic and vibrational excitations on photoinduced charge separation (CS) and charge recombination (CR). Upon photoexcitation, the singlet excited state of ZnP (1ZnP...

Saratzis A, Patrone L, Secemsky EA, Dua A, Zayed H, Torsello G et al.

Peripheral arterial disease (PAD) is a major global health burden often requiring endovascular intervention. Complex lesion morphologies such as calcification or long occlusions limit procedural success. Vessel preparation (VP) techniques, including atherectomy and intravascular lithotripsy, are ...

Kumar A, Männistö MK, Kerkhof LJ, Häggblom MM

The Arctic tundra and boreal forest regions are affected by ongoing climate change, leading to increased warming, increased plant production, and heightened microbial activity. Microbes play a key role in carbon release from stored soil organic matter, and characterizing their diversity and funct...

Liu M, Li W, Ji Y, Chen Y, Wei G, Huo J et al.

Colorectal cancer is a leading cause of cancer mortality characterised by a unique metabolic microenvironment and complex interactions with the gut microbiota. Lactylation, a novel post-translational modification derived from lactate, has emerged as a key epigenetic regulator connecting metabolic...

Leung YS, Jiang D, St John P, Tate R

BackgroundDementia prevalence and incidence rise sharply among the oldest-old (≥85 years), yet whether age-at-diagnosis shapes functional trajectories remains unclear. Understanding age-specific patterns is critical for tailoring care strategies.ObjectivesTo determine whether age at dement...

Williams S, Meran L, McCartney S, Harrow P, Lee JC

Inflammatory bowel disease (IBD) arises from a multifaceted interplay of genetic predisposition, environmental triggers, microbial dynamics, and immune dysregulation. This complex network of interacting factors disrupts gut homeostasis, leading to chronic relapsing inflammation in the gastrointes...

Thorat AS, Sartape R, Chauhan R, Mishra R, Singh MR, Shah JK et al.

The addition of ionic liquids (ILs) to a mixture containing a molecular solvent and other ionic species can induce the heterogeneous redistribution of cations and anions at the gas-liquid interface. This nonuniform redistribution of cations and anions driven by the differences in the solvophilici...

Van Wauwe J, Janarthanan P, Craps S, Kc A, Asuncion L, Vrancaert P et al.

TF (transcription factor) Prdm16 (positive regulatory domain-containing protein 16) regulates hematopoietic and neuronal stem cell homeostasis, adipose differentiation, and cardiac development. Its role in the circulatory system extends beyond the heart, as Prdm16 loss in arterial endothelial cel...

Callegari S, Mubarak E, Romain G, Golledge J, Mena-Hurtado C, Smolderen KG et al.

Peripheral artery disease (PAD) affects millions worldwide and is associated with high mortality, major amputations, and detrimental effects on functional and health status. PAD management is multifactorial and encompasses addressing cardiovascular and metabolic risk factors, improving symptoms a...

Ruberti A, Flores-Umanzor E, Sanchis L, Pilgrim T, Regueiro A, Garot P et al.

Paravalvular leak (PVL) is a well-known complication of valve replacement, occurring in up to 10% of aortic and 17% of mitral prosthetic valves. Although many leaks are small and clinically insignificant, ≈1% to 5% of cases are associated with clinically relevant complications, such as hea...

Doherty JF, Rossouw B, Foster LJ, Matthews BJ

Parasites with complex life cycles produce large numbers of free-living infectious stages to overcome the low odds of successful transmission between hosts. These stages often infect non-competent or "dead-end" hosts, which cannot support parasite development or transmission. While typically view...

Nagahara T, Iwata T, Wada K, Yamamoto K, Shimizu M, Nagatani Y et al.

Cemental tear, representing separation of cementum from the root surface, is a rare but challenging condition often mimicking vertical root fracture or endodontic-periodontal lesions. Despite advances in regenerative therapy, a predictable treatment protocol for cemental tears with non-contained ...

Scheyer ET, Hickerson R, de Arbeloa L, Gomes P

A digital guided surgery system (DSD Clic-Guide, Digital Smile Design) is a digital rehabilitation planning system recommended in the rehabilitation of fully edentulous jaws, which orients implant placement procedures, immediate provisional loading, and final prosthesis based on an ideal facially...