Thymosin Beta-4 Research

Li Y, Liu T, Zhang K, Wang J, Zhang J, Zhang J et al.

Photoaffinity Labeling-Affinity-Based Protein Profiling (PAL-AfBPP) provides breakthrough solutions in a variety of fields such as target protein discovery. The selection of photoaffinity connectors is the key component of PAL-AfBPP probe design and application. At present, the development of org...

Zhang S, Wang P, Yang Y, Tang Y, Wu Z, Fang X et al.

Catalytic combustion with a DPF honeycomb is currently a feasible way to abate soot particulate pollution, but it is still of great necessity to develop more efficient and cost-effective catalysts. To accomplish this, Ru was adopted to decorate a Tb2Ce2O7+x solid solution in its lattice (Ru-TC) o...

Zhou Q, An Y, Zhang X, Huang C, Tang X, Ye W et al.

This work reports two lanthanide clusters, [Ln4(RPO3)2(RPO3H)(tBuCO2)7(tBuCO2H)3(H2O)3] (Ln = Eu, Tb; RPO3H2 denotes (9-methyl-9H-fluoren-9-yl)phosphonic acid). A comprehensive series of characterizations was performed for the Eu4 and Tb4 clusters, including X-ray crystallography, X-ray...

Di H, Huang J, Zhang D, Ni F, Zheng R, Geng H et al.

Over the past decades, the escalating global burden of kidney disease has underscored an urgent need for innovative therapeutic strategies. Thymosin β4 (Tβ4), a highly conserved 43-amino-acid peptide encoded by the X-linked TMSB4x gene, is the predominant β-thymosin in mammalian...

Liang Y, Yu Z, Du S, Guo Y, Li J, Yan Y et al.

Intrauterine adhesions (IUA), a leading cause of female infertility, result from a pathological switch in the uterine injury response from regeneration to fibrotic scarring. Current treatments are often inadequate as they fail to address this fundamental shift. Here, we report a "decidualization-...

Keplinger AJ, Srinivasan PA, Christensen SM, Suarez C, Ruthenburg AJ

While predominantly studied in cytoplasmic contexts, actin plays critical roles in the nucleus, regulating genome accessibility, transcription, and DNA repair. Cell-based studies have contributed to a widely accepted model in which the import factor importin 9 (IPO9) acts in concert with the acti...

Mayfield CK, Bolia IK, Feingold CL, Lin EH, Liu JN, Rick Hatch GF et al.

Therapeutic peptides are short-chain amino acids that regulate cellular functions and facilitate biochemical processes. In recent years, there has been significant growth in the global market for therapeutic peptides and thus its popularity among patients. Given the increase in the development of...

He S, Yuan M, Feng C, Zhang Y, Che J

Skin wound treatment is hindered by the poor penetration of large therapeutics and a lack of treatments that effectively regulate immune environments. While microneedles (MNs) can bypass the skin, they destabilize sensitive peptides, including thymosin β4 (Tβ4), whose immunomodulatory...

Grzędzicka J, Świderska B, Sitkiewicz E, Dąbrowska I, Witkowska-Piłaszewicz O

Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high-throughput proteomics.We hy...

Ou H, Chen R, Zhou L, Zhang Y, Zhao S, Yang Z et al.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder defined by neuroinflammation, neurite atrophy, and cognitive decline. This study explored the therapeutic potential of Thymosin β4 (Tβ4)-derived peptides (TB500 and Ac-SDKP) in mitigating AD-related neuropathology. U...

Stewart WG, Hejl CD, Guleria RS, Gupta S

Acute ischemic injury causes impairment of blood brain barrier (BBB) permeability and is considered as secondary insult in the brain after traumatic brain injury (TBI). The mechanisms underlying these events are incomprehensible and therefore therapeutic opportunities are limited. Although drugs ...

Sun YS, Bai XQ, Sun KD, Li J, Liu L, Chen YY et al.

Mast cells (MCs) under stress conditions contribute to the development of irritable bowel syndrome (IBS), yet their precise mechanisms in IBS remain unclear.To investigate the role of MC-derived thymosin β4 (Tβ4) in stress-induced intestinal barrier dysfunction.The colonic mucus T&#x3...

Wang M, Cai J, Zeng C, Li M, Wang Y, Geng S et al.

This study examined the effects and underlying mechanisms of combining pig manure composts, produced by different fermentation methods, with chemical fertilizers on winter wheat yield, nutrient uptake, light-thermal physiology, soil fertility, and microbial communities.Field experiment was conduc...

Nguyen J, Verma S, Vuong VT, Queener H, Coulson-Thomas VJ, Gesteira TF et al.

Thymosin beta-4 (TB4) is a small peptide upregulated in injured tissues, playing roles in cell migration, angiogenesis, inflammation, and oxidative stress. Studies show TB4 significantly promotes corneal wound healing after injury, leading to a clinical trial (RGN-259), with full US Food and Drug...

Zhang Y, Dong Q, Bian X, Qiao Z, Cui C, Yang N et al.

Despite advancements in primary percutaneous coronary intervention (PCI), cardiac dysfunction remains a challenge in patients with ST-segment elevation myocardial infarction (STEMI). Although thymosin beta 4 has shown cardioprotective effects in preclinical MI models, its impact on chronic cardia...

Zamberlan M, Semenzato M

Tunneling nanotubes (TNTs) are dynamic, actin-based intercellular structures that facilitate the transfer of organelles, including mitochondria, between cells. Unlike other protrusive structures such as filopodia and cytonemes, TNTs exhibit structural heterogeneity and functional versatility, ena...

Guo L, Wang H, Li N, Wang J, Yu M, Li Y et al.

Ovarian cancer is a gynecologic malignancy with high mortality and poor prognosis. Chemoresistance is a key cause of ovarian cancer recurrence and metastasis. It has been found that some bioactive peptides can inhibit the growth and metastasis of cancer cells and promote cell apoptosis, thus exer...

Su Y, Han F, Chen H, Li Y, Sun L, Liang L et al.

Biofilm-associated infections (BAIs) pose a serious threat to public health; in particular, a reactive oxygen species (ROS)-rich biofilm microenvironment can weaken the immunological response of antimicrobial natural killer (NK) cells. Conventional phototherapy cannot consistently inhibit the esc...

Wang Y, Yue S, Yang F, Chen L, Singh A, Marciniak M et al.

Early-life adversities increase vulnerability to substance use disorders, which are characterized by persistent, uncontrollable drive to seek drugs, often leading to relapse. Previously, we reported that early social isolation (ESI) during adolescence potentiates heroin-seeking in mice. However, ...

Jin Z, Li H, Li J, Chang Y, Piao Z, Jin Q et al.

Thymosin β4 (Tβ4) plays a critical role in breast cancer progression, yet its molecular mechanism remains unclear. In this study, we identified that Tβ4 is significantly upregulated in breast cancer tissues and cell lines, and its high expression correlates with poor clinical ou...