Thymosin Alpha-1 Research

Zhang L, Xu C, Su T, Xiao T, Yi X, Feng Y et al.

Acute pancreatitis (AP) ranges from mild to severe, and severe disease frequently causes multi-organ damage, with intestinal injury being a major complication. The mechanisms underlying SAP-induced intestinal injury remain unclear, particularly regarding spatial cellular reorganization and functi...

Li T, Wu BL, Yu CL, Jin LY

To report a case of a nasopharyngeal carcinoma patient who developed multisystem immune-related adverse events (irAEs) after treatment with sintilimab (PD-1 inhibitor) in combination with thymosin alpha-1 (Tα1). The patient presents with high fever, rash, interstitial pulmonary edema, and m...

Mishra S, Telang G, Sureshbabu A, Kulkarni S, Thayagrajan S, Kumar AWS et al.

Thymosin α1 (Tα1) is an endogenous thymic peptide that enhances immune competence through activation of T cells, dendritic cells, and innate immune pathways. However, its direct impact on CD8+ T cell-mediated antitumor immunity in breast cancer remains unclear. In this study, CD8+ T c...

Li X, Liu C, Bai Y

Numerical simulations of the forming limit diagram (FLD) for SUS430/Al1050/TA1 laminated metal composites (LMCs) are conducted through the crystal plasticity finite element (CPFE) model integrated with the Marciniak-Kuczyński (M-K) theory. Representative volume elements (RVEs) that reconstr...

Li G, Yu T, Yang P, Zhao S, Zhang S, Ma H et al.

The adjustable-ring-mode (ARM) scanning laser was used to perform butt welding on 0.5 mm thick TA1 titanium alloy and 304 stainless steel (SS304) thin sheets, with 1.2 mm diameter AZ61S magnesium alloy welding wire as the filling material. Microhardness test results show that the hardness distrib...

Kamble AV, M RR

Tetracyanoethene (TCNE)-integrated π-systems exhibit strong donor-acceptor (D-A) interactions and display intriguing optical and electronic properties, making them ideal candidates for electrochromism. However, such studies have never been carried out. Here, we report the synthesis and elec...

Tian X, Liu Q, Cheng S, Chen W, Zhang C, Wang Y et al.

Phaeocystis globosa-forming blooms pose serious ecological and economic risks by releasing hemolytic toxins, inducing hypoxia, threatening fisheries, and even obstructing seawater intake in nuclear power plants. Rapid and reliable detection of this alga is therefore critical. Here, a rapid, sensi...

Yuan B, Etzold H, Gröngröft A

Anaerobic co-digestion of wheat straw and cattle manure offers a route to valorize agricultural residues, but the management of the resulting digestate remains a challenge. This study investigates the combined influence of liquid digestate recirculation (LDR) and urea addition on process performa...

Shyanti RK, Sharma S, Haque M, Tiwari RK, Singh R, Mishra M et al.

Triple-negative breast cancer (TNBC) is characterized by aggressive metastatic behavior driven through epithelial-to-mesenchymal transition (EMT). CD1d, a non-classical MHC molecule, modulates immune responses via Natural Killer T (NKT) cells and is implicated in tumor progression. This study exa...

Wu L, Wang Q, Hong X, Cai X, Zhang L, Li M et al.

Persisters represent a transient, antibiotic-tolerant subpopulation within isogenic bacterial populations, contributing to infection relapses. However, the mechanisms driving persister formation and resuscitation remain elusive. Here, we developed nano-flow cytometry (nFCM)-based methods for sing...

Schroeder B, Prasad P, Gbadegesin O, Gupta S, Frazer R, Heaney S et al.

Neurological immune related adverse events (N-irAEs) following immune checkpoint inhibitor (ICI) therapy are associated with significant morbidity and mortality. The early involvement of neurological services is therefore recommended to assist diagnosis and guide management. However, the practica...

Gu Y, Deng J, Li Y, Liu D

Panax notoginseng is a traditional medicinal and food-homologous plant in China; however, root rot, primarily caused by Fusarium solani, has become a devastating disease that severely compromises the yield and quality of P. notoginseng. In this study, a strain of Trichoderma asperellum (designate...

Zhang C, Shukal S

Precise control of gene expression is essential to synthetic biology and metabolic engineering, particularly for microbial production. The widely used IPTG-inducible T7lac promoter (PT7lac) offers strong expression but suffers from metabolic burden, inclusion body formation, and induction heterog...

Yu B, Chen L, Huang D

Sepsis, a severe infectious disease, is characterized by high mortality and significant therapeutic challenges. This study aims to systematically review the impact of immunomodulatory therapy on sepsis-related mortality and create an evidence-based foundation for sepsis treatment.A systematic sea...

Simonova MA, Ivanov I, Shoshina NS, Komyakova AM, Makarov DA, Baranovskii DS et al.

Aging is characterized by immune decline, mainly due to thymic involution-the age-related shrinkage of the thymus gland. This leads to reduced T-cell production, chronic inflammation, and increased susceptibility to age-related diseases. Thymosin alpha-1 (Tα1), a peptide hormone produced by...

Wang YS, Li CF, Ma RP, Yang FL, Zhang JB, Li ZH et al.

Objective: To establish a predictive system for aerosol drug deposition by integrating computational fluid dynamics (CFD) and artificial intelligence (AI) modeling, and to propose optimized strategies for intranasal drug delivery in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) ...

Wang H, Wang L, Zhong H, Li Z

Platinum-resistant recurrent ovarian cancer remains a major therapeutic challenge. Immune checkpoint inhibitors (ICIs) combined with chemotherapy are widely used, but clinical benefits remain limited. Thymosin α1 (Tα1), an immunomodulatory peptide, may synergize with ICIs to enhance a...

Campos-Jiménez E, Juarez-Moreno K, Martínez-Soto D, Cabello-Pasini A, Castro-Longoria E

Background/Objectives:Botrytis cinerea is a necrotrophic fungal plant pathogen responsible for the gray mold disease, affecting several crops of economic importance worldwide. The primary line of control for the disease in the field and post-harvest fruits includes the application of fungicides. ...

Xu M, Chen R, Kong Y, Zhang J, Xing P, Zhao X et al.

Radiotherapy combined with immunotherapy shows increasing efficacy in treating metastatic malignancies; however, positive outcomes may be negatively impacted by lymphocytopenia. Previous studies suggest thymosin α1 (Tα1) may mitigate radiation-induced lymphocytopenia. This study retro...

Pollock L