Thanatin Research

Mohanty J, Murali A

Plant viruses pose a serious threat to global agriculture and although chemical, genetic, and biological control strategies exist, but each method have limitations in effectiveness and sustainability. Recently, the use of microbial peptides for curbing the movement of plant viruses has gained mom...

Abdullah SJ, Guan JS, Mu Y, Bhattacharjya S

Antimicrobial peptides (AMPs), also referred to as host defense peptides, are promising molecules in the development of the next generation of antibiotics against drug-resistant bacterial pathogens. Thanatin comprises a family of naturally occurring cationic AMPs derived from several species of i...

Pan X, Chen TA, Shafieichaharberoud F, Tennant SM, Baliban SM, Huang X et al.

Salmonella species (Salmonella spp.) are a major foodborne pathogen and a leading cause of gastroenteritis in humans. The emergence and continued spread of multidrug-resistant Salmonella spp. suggest the urgent need for novel vaccines to complement antibiotics. Currently, there are no approved va...

Pipiya SO, Ivanova AO, Mokrushina YA, Eliseev IE, Gabibov AG, Smirnov IV et al.

Antibiotic resistance threatens global healthcare. In clinical practice, conventional antibiotics are becoming gradually less effective. Moreover, the introduction of new antimicrobial agents into clinical practice leads to the emergence of resistant pathogenic strains within just a few years. He...

Wu X, Liu S, Gong Z, Liu X, Dong Z, Chen J et al.

Rip-thanatin (RipT), a natural antimicrobial peptide derived from Riptortus pedestrisc, is comprised of 18 amino acid residues. Herein, a series of Rip-thanatin derivatives were synthesized using cationic and amphiphilic design strategies of antimicrobial peptides (AMPs) by employing an amino aci...

Karimooy AN, Jarchi M, Forouzanfar F, Tanhaiean A, Esmaeili A, Mohammadipour HS et al.

This study investigated the antimicrobial properties of the thanatin peptide against oral bacteria associated with dental caries and endodontic failures. Additionally, the cytotoxic effects of this peptide on human gingival fibroblast cells (HGFCs) were assessed.The antimicrobial property of than...

Hoose A, Garcia-Ruiz J, Blake C, Lally CCM, Briones A, Hoogenboom BW et al.

Antimicrobial resistance has motivated the search for antimicrobial agents with multimodal mechanisms of action. Host defense peptides and bacteriocins hold particular promise in this regard. Among many molecules discovered to date, thanatin appears to represent the properties of the two classes ...

Abdullah SJ, Guan JS, Mu Y, Bhattacharjya S

Host defense antimicrobial peptides (AMPs) are promising lead molecules with which to develop antibiotics against drug-resistant bacterial pathogens. Thanatin, an inducible antimicrobial peptide involved in the host defense of Podisus maculiventris insects, is gaining considerable attention in th...

Campbell O, Allsopp R, Klauda JB, Monje V

All-atom molecular dynamics (AAMD) is a computational technique that predicts the movement of particles based on the intermolecular forces acting on the system. It enables the study of biological systems at atomic detail, complements observations from experiments, and can help the selection of ex...

Deng X, Wang H, Fang C, Xu M, Chu Z, Li M et al.

Thanatin, a potent cationic antimicrobial peptide, has demonstrated remarkable efficacy against new NDM-1 producing bacteria. However, its clinical application is hampered by suboptimal stability in circulation and limited bioavailability in the human body. To overcome these challenges, a novel t...

Panteleev PV, Teplovodskaya JS, Utkina AD, Smolina AA, Kruglikov RN, Safronova VN et al.

Background: Endogenous antimicrobial peptides (AMPs) are evolutionarily ancient molecular factors of innate immunity that play a key role in host defense. The study of the diversity of animal defense peptides has important applications in the context of the growing global antimicrobial resistance...

Shepperson OA, Harris PWR, Brimble MA, Cameron AJ

Thanatin is a β-hairpin antimicrobial peptide cyclised by a single disulfide bond that has shown potent broad-spectrum activity towards bacterial and fungal pathogens. Towards Gram-negative species, thanatin acts both by forming trans-membranal pores and inhibiting outer membrane biogenesis...

Andrés MT, Yount NY, Acosta-Zaldívar M, Yeaman MR, Fierro JF

Human lactoferrin (hLf) is an innate host defense protein that inhibits microbial H+-ATPases. This protein includes an ancestral structural motif (i.e., γ-core motif) intimately associated with the antimicrobial activity of many natural Cys-rich peptides. Peptides containing a complete &#x3...

Liu Q, Wu Q, Xu T, Malakar PK, Zhu Y, Liu J et al.

Antimicrobial resistance poses an escalating threat to human health, necessitating the development of novel antimicrobial agents capable of addressing challenges posed by antibiotic-resistant bacteria. Thanatin, a 21-amino acid β-hairpin insect antimicrobial peptide featuring a single disul...

Lim J, Myung H, Lim D, Song M

This study addresses the urgent need for infection control agents driven by the rise of drug-resistant pathogens such as Acinetobacter baumannii. Our primary aim was to develop and assess a novel endolysin, Tha-PA90, designed to combat these challenges.Tha-PA90 incorporates an antimicrobial pepti...

Chung SF, Tam SY, Wong WT, So PK, Cheong WL, Mak CW et al.

We successfully developed a fluorescent drug sensor from clinically relevant New Delhi metallo-β-lactamase-1 (NDM-1). The F70 residue was chosen to be replaced with a cysteine for conjugation with thiol-reactive fluorescein-5-maleimide to form fluorescent F70Cf, where "f" refers to fluoresc...

Abdullah SJ, Yan BTS, Palanivelu N, Dhanabal VB, Bifani JP, Bhattacharjya S et al.

Currently, viable antibiotics available to mitigate infections caused by drug-resistant Gram-negative bacteria are highly limited. Thanatin, a 21-residue-long insect-derived antimicrobial peptide (AMP), is a promising lead molecule for the potential development of novel antibiotics. Thanatin is e...

Ding L, Yang Z, Sun B

The escalating challenge of Carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospital-acquired pneumonia (HAP) is closely linked to the blaNDM-1 gene. This study explores the regulatory mechanisms of blaNDM-1 expression and aims to enhance antibacterial tactics to counteract the spread and in...

Abdullah SJ, Mu Y, Bhattacharjya S

Gram-negative bacteria are intrinsically more resistant to many frontline antibiotics, which is attributed to the permeability barrier of the outer membrane, drug efflux pumps and porins. Consequently, discovery of new small molecules antibiotics to kill drug-resistant Gram-negative bacteria pres...

Pipiya SO, Kudzhaev AM, Mirzoeva NZ, Mokrushina YA, Ziganshin RH, Komlev AS et al.

The global spread of antibiotic resistance marks the end of the era of conventional antibiotics. Mankind desires new molecular tools to fight pathogenic bacteria. In this regard, the development of new antimicrobials based on antimicrobial peptides (AMPs) is again of particular interest. AMPs hav...