Teriparatide Research

Kendler DL, Habert J, Khan AA, Kherani RB, Kim S, Kovacs CS et al.

Although patients with remote or brief prior exposure to osteoporosis treatments are strictly not "treatment naive," osteoporosis treatment effects on bone mineral density and bone turnover resolve over time. It would therefore be useful to categorize patients with remote or brief ...

Keshav K, Kaustubh K, Mishra P

Intertrochanteric or pertrochanteric fractures are common among the elderly population. They are primarily treated by internal fixation. Malunion, delayed union, and implant-related complications are often seen in this population due to osteoporosis, which leads to inadequate bone stock and delay...

Wadhwa H, Isakoff KJ, Pham NS, Goodnough LH, Bishop JA, Gardner MJ et al.

Fragility fractures are common among older adults with osteoporosis, yet most patients do not receive recommended treatment. Prescribing trends in the US after fragility fractures and patient-level predictors of medication prescription remain unclear. This study evaluates prescribing patterns and...

Jain H, Sarikonda A, Ahluwalia R, Zakieh O, Montgomery A, Navid W et al.

Though the use of anabolic bone agents has proven effective in adult spinal deformity (ASD) surgery, prescription and approval of these medications remains a challenge. In osteopenic/osteoporotic patients undergoing ASD surgery, we sought to determine the impact of a bone optimization clinic on: ...

Xue Q, Gu Y, Li J, Qin R, Li M, Li Y et al.

Peak bone mass (PBM) critically determines lifelong skeletal health. We showed that dietary supplementation with pyrroloquinoline quinone (PQQ) - a water-soluble bioactive compound that activates nuclear factor erythroid 2-related factor 2 (Nrf2) signaling - during pregnancy or post-weaning enhan...

Mori S, Tanaka S, Kuroda T, Hagino H, Soen S

Crooks SA, Kuršumović K, Lewis TL, Kanakaris NK

Background: Fragility fractures of the pelvis (FFPs) are increasingly prevalent given ageing populations. Conservative management is often primarily utilised due to its initial minimal displacement and the high risks of surgery in this vulnerable population. However, this can lead to rapid decond...

Yukishima T, Kobayakawa T, Hirano Y, Kanayama Y, Niimi R, Etani Y et al.

To investigate the effectiveness of denosumab (DMAb), teriparatide (TPTD), and romosozumab (ROMO) in patients with glucocorticoid-induced osteoporosis (GIOP).This multicentre, retrospective cohort study employed propensity score matching to select 42 patients per treatment group (92.1% female, me...

Shahid SR, Shahid K, Ehsan S, Khalid M, Waafira A

Hypoparathyroidism (HypoPT) is a rare endocrine disorder characterized by insufficient parathyroid hormone (PTH) levels, leading to hypocalcemia and hyperphosphatemia. Affecting approximately 70 000-90 000 individuals in the United States, HypoPT can arise from genetic mutations or, mos...

Guo J, Zhao W, Feng L, Bu X

Psoriasis is a chronic, immune-mediated inflammatory skin disease induced by genetic and environmental factors, with dysfunctional contact inhibition of keratinocytes being a core pathological feature leading to hyperproliferation. Our previous gene chip screening identified a significant downreg...

Chen L, Wang Q, Gu M

Anti-sclerostin antibodies are novel biologics for the treatment of postmenopausal osteoporosis, while their efficacy and safety are yet to be fully understood. The aim of this systematic review and meta-analysis is to evaluate the efficacy and safety of anti-sclerostin antibodies compared to pla...

Brown JP

Kumar BY, Loganathan B, Vijayakumar D

Elderly osteoporotic patients with kyphosis secondary to spinal tuberculosis (TB) are at high risk for implant failure. For these patients, polymethylmethacrylate (PMMA)-augmented pedicle screw fixation provides immediate stability but increases the risk of infection. Here, we evaluated the outco...

Matsumoto H, Tsukamoto M, Okimoto N, Ikeda S, Tanaka M, Takahashi M et al.

Studies launched in Japan on once-weekly teriparatide (1/W-TPTD) and twice-weekly teriparatide (2/W-TPTD) are limited. Therefore, we examined the effects of sequential therapy using anti-resorptive agents after administering 1/W-TPTD and 2/W-TPTD using dual-energy X-ray absorptiometry (DXA) and D...

Bonifacio M, Ruggiero M, Lucchetti L, Musorrofiti MG, La Cava G, Chiappetta A et al.

Background/Objectives: Abaloparatide is an osteoanabolic therapy used in patients at high risk of fracture; however, the breadth of evidence across routes, comparators, and sequential strategies has not yet been comprehensively summarized. This study aimed to evaluate the efficacy and safety of a...

Cho YH, Lim C, Kim D

Background/Objectives: Surgical management of atypical femoral fractures (AFFs) stabilized with intramedullary (IM) nailing is frequently challenged by delayed union or nonunion due to the severely suppressed bone turnover characteristic of bisphosphonate-related bone pathology, often leading to ...

Lee KI, Chen JH, Chen KH

Osteoporosis is a prevalent skeletal disorder characterized by reduced bone mass and microarchitectural deterioration, leading to increased fracture risk, particularly in aging populations. Postmenopausal osteoporosis (PMOP) remains the most common primary form and results from abrupt estrogen de...

Nishino T, Hyodo K, Matsumoto Y, Yanagisawa Y, Shimasaki K, Watanabe R et al.

Background/Objectives: Atypical femoral fracture (AFF) represents a diagnostic and therapeutic challenge, particularly in autoimmune disease patients receiving long-term bisphosphonate (BP) and glucocorticoid (GC) therapy. Although bilateral AFF is common, the radiographic evolution of asymptomat...

Amorim T, David NL, Moturi S, Turnquist LR, Holmes TM, Bouxsein ML et al.

Women with anorexia nervosa have low bone mineral density and increased fracture risk. We conducted a randomized, placebo-controlled trial investigating the effects of 6 months of teriparatide in anorexia nervosa. Teriparatide led to trends in improvements in bone structure. Longer-term studies a...

Choi BS, Jung M, Cho BW, Chung JY, Ha JK, Han HS et al.

Total knee arthroplasty (TKA) is a widely performed procedure for end-stage arthritis, with cemented fixation historically dominating owing to its immediate stability and ability to compensate for minor bone defects. However, concerns over the long-term durability of cemented implants, particular...