TB-4 Fragment (Ac-SDKP) Research

Di H, Huang J, Zhang D, Ni F, Zheng R, Geng H et al.

Over the past decades, the escalating global burden of kidney disease has underscored an urgent need for innovative therapeutic strategies. Thymosin β4 (Tβ4), a highly conserved 43-amino-acid peptide encoded by the X-linked TMSB4x gene, is the predominant β-thymosin in mammalian...

Li L, Wang H, Wei L, Su J, Zeng Z, Tan J et al.

While stents are cornerstone treatments for atherosclerosis, in-stent restenosis remains a challenge. Engineering stent surfaces with specific biochemical signals can prevent this by promoting the crucial and timely regeneration of the endothelium. In this work, Ac-SDKP (N-Acetyl-Ser-Asp-Lys-Pro)...

Ou H, Chen R, Zhou L, Zhang Y, Zhao S, Yang Z et al.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder defined by neuroinflammation, neurite atrophy, and cognitive decline. This study explored the therapeutic potential of Thymosin β4 (Tβ4)-derived peptides (TB500 and Ac-SDKP) in mitigating AD-related neuropathology. U...

Li WL, Liu L, He Y, Yao NN, Deng HJ, Qian Y et al.

Objective: To examine the regulatory effects of a potential antifibrotic tetrapeptide called N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) on the expression of epidermal growth factor (EGFR) and signal transducer and activator of transcription 3 (STAT3) in lung tissues with fibrosis induced by ...

Hamid S, Sarkar S, Peng H, Khalid M, Ortiz PA, Xu J et al.

Eplerenone, a mineralocorticoid receptor antagonist, is an anti-hypertensive and cardioprotective drug. We showed that N-Acetyl-Seryl-Aspartyl-Proline (Ac-SDKP) exerts beneficial effects on the heart. Whether Ac-SDKP provides additional cardioprotective effects if combined with eplerenone in angi...

Li W, Ma S, Liu L, He Y, Guo W, Qian Y et al.

The main objective of this study was to investigate whether the antifibrotic tetrapeptide N-acetyl-serinyl-aspartyl-lysinyl-proline (Ac-SDKP) affects the p38MAPK/mTOR autophagy pathway by regulating heat shock protein 27 (HSP27)-mediated autophagy during the treatment of silicosis-related fibrosi...

Gregory KS, Ramasamy V, Sturrock ED, Acharya KR

Angiotensin I-converting enzyme (ACE) is a dipeptidyl carboxypeptidase with two homologous catalytic domains [N- and C-domains (nACE and cACE)] that can cleave a range of substrates. cACE primarily cleaves the inactive decapeptide angiotensin I into the potent vasopressor angiotensin II, whereas ...

Kamarehei M, Zahednasab H

Oxidative stress and endoplasmic reticulum (ER) stress are key contributors to the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD), for which no definitive cure currently exists. This study investigated the neuroprotective potential of the N-acetyl-seryl-aspartyl-ly...

Ameri Z, Shahabi A, Farsinejad A, Bardsiri MS, Javedani H, Bagher Z et al.

biocompatible hydrogel glue with vigorous wet tissue adhesion has attracted considerable attention for controlling severe hemorrhage and enhancing wound healing process. In this study, anti-scar hemostatic glue was prepared using mussel-inspired catechol-based strategy for bleeding control, heali...

Zhang Q, Li H, Zhuang T, Xu L, Wu W, Pi J et al.

Members of the CCN matricellular protein family are crucial in various biological processes. This study aimed to characterize vascular cell-specific effects of CCN5 on neointimal formation and its role in preventing in-stent restenosis (ISR) after percutaneous coronary intervention (PCI).Stent-im...

Ghanem M, Justet A, Jaillet M, Vasarmidi E, Boghanim T, Hachem M et al.

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with limited therapeutic options. Fibroblast growth factor receptor-4 (FGFR4) is a known receptor for several paracrine fibroblast growth factors (FGFs). FGFR4 is also the main receptor for FGF19, an endocrine FGF that was demonstr...

Suhail H, Peng H, Matrougui K, Rhaleb NE

Inflammation and cardiac fibrosis are prevalent pathophysiologic conditions associated with hypertension, cardiac remodeling, and heart failure. Endoplasmic reticulum (ER) stress triggers the cells to activate unfolded protein responses (UPRs) and upregulate the ER stress chaperon, enzymes, and d...

Liu S, Jin R, Zheng G, Wang Y, Li Q, Jin F et al.

Kinesin family member 3 A (KIF3A) decrease have been reported in silicotic patients and rats. However, the detailed mechanisms of KIF3A in silicosis remain unknown. In this study, we demonstrated that KIF3A effectively blocked the expression of β-catenin and downstream myocardin-relate...

Bhatia D, Srivastava SP

Han S, Wang S, Fan X, Chen M, Wang X, Huang Y et al.

Polycystic ovary syndrome (PCOS) is an endocrine disorder and metabolic syndrome. Ovarian fibrosis pathological change in PCOS has gradually attracted people's attention. In this study, we constructed a PCOS mouse model through the use of dehydroepiandrosterone. Sirius red staining showed that th...

Sonkawade SD, Xu S, Kim M, Nepali S, Karambizi VG, Sexton S et al.

Cardioprotective effects of N-acetyl-ser-asp-lys-pro (Ac-SDKP) have been reported in preclinical models of myocardial remodeling. However, the rapid degradation of this endogenous peptide in vivo limits its clinical use.To prolong its bioavailability, Ac-SDKP was encapsulated by phosphocholine li...

Gong HB, Zhang CM, Tang XY, Gong RB, Miao ZY, Deng HJ et al.

Objective: To systematically study the anti-fibrotic effect of N-acetyl-seryl-as partyl-lysyl-proline (Ac-SDKP) on pulmonary fibrosis. Methods: In May 2021, a computer search was performed on CNKI, Wanfang Knowledge Service Platform, VIP.com, China Biomedical Literature Database, Pubmed, OVID and...

Liu AD, Yang F

N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is an endogenous short peptide produced through the continuous hydrolysis of Thymosin β4 by meprin-α and prolyl oligopeptidase. It has the functions of immune regulation, promoting angiogenesis, tumorigenesis and anti-fibrosis in organs....

Suhail H, Peng H, Xu J, Sabbah HN, Matrougui K, Liao TD et al.

Angiotensin-converting enzyme (ACE) hydrolyzes N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) into inactive fragments through its N-terminal site (ACE-N). We previously showed that Ac-SDKP mediates ACE inhibitors' cardiac effects. Whether increased bioavailability of endogenous Ac-SDKP caused by...

Kleinman HK, Kulik V, Goldstein AL

Wound healing involves a rapid response to the injury by circulating cells, followed by inflammation with an influx of inflammatory cells that release various factors. Soon after, cellular proliferation begins to replace the damaged cells and extracellular matrix, and then tissue remodeling resto...