Syn-Ake Research

Zhu M, He X, Zhu Z, Lynch S, Wang H, Zhou X et al.

This study aimed to explore the anti-skin aging efficacy of a novel serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide and laminaria extract through one ex-vivo study and two clinical studies.In ex-vivo study, skin samples were expo...

Sánchez-Campillo I, Gratacòs-Batlle E, Pérez-García S, Nguyen HS, Triola G, Mootz HD et al.

The reaction between C-terminal α-thioester and N-terminal cysteinyl peptides is known as native chemical ligation (NCL). Alkyl α-thioesters are traditionally prepared in NCL due to their higher thermodynamic stability, which endows resistance to hydrolysis and easier peptide handling...

Ghazvini K, Taghiabadi Z, Karimi MA, Hosseini Bafghi M, Paryan M, Amirfakhrian R et al.

Inflammatory bowel disease (IBD) is linked to dysregulated mucosal immunity, microbiota imbalances, and environmental factors, though its exact cause remains unknown. Current treatments often have limitations, necessitating innovative therapies. This review evaluates anti-inflammatory peptides (A...

da Cunha E Silva FA, Silva BRD, Barros LR, Beraldo-Neto E, Maleski ALA, Alberto-Silva C et al.

Introduction: Snake venoms are rich sources of bioactive peptides with therapeutic potential, particularly against neurodegenerative diseases linked to oxidative stress. While the peptide fraction (<10 kDa) from Bothrops jararaca venom has shown in vitro neuroprotection, analogous fractions fr...

Osmakov DI, Khasanov TA, Maleeva EE, Pavlov VM, Palikov VA, Belozerova OA et al.

Mambalgins are peptide inhibitors of acid-sensing ion channels type 1 (ASIC1) with potent analgesic effects in models of inflammatory and neuropathic pain. To optimize recombinant peptide production and enhance pharmacological properties, we developed a mutant analog of mambalgin-1 (Mamb) through...

Ding L, Zhai Z, Qin T, Lin Y, Shuang Z, Sun F et al.

Coagulation factor XIa is a new serine-protease family drug target for next-generation anticoagulants. With the snake venom Kunitz-type peptide BF9 as the scaffold, we obtained a highly active XIa inhibitor BF9-N17K in our previous work, but it also inhibited the hemostatic target plasmin. Here, ...

Camargo LC, Gering I, Mastalipour M, Kraemer-Schulien V, Bujnicki T, Willbold D et al.

Over a century has passed since Alois Alzheimer first described Alzheimer's disease (AD), and since then, researchers have made significant strides in understanding its pathology. One key feature of AD is the presence of amyloid-β (Aβ) peptides, which form amyloid plaques, and therefo...

Miyamoto JG, Kitano ES, Zelanis A, Nachtigall PG, Junqueira-de-Azevedo I, Sant'Anna SS et al.

Snake venoms are primarily composed of proteins and peptides, which selectively interact with specific molecular targets, disrupting prey homeostasis. Identifying toxins and the mechanisms involved in envenoming can lead to the discovery of new drugs based on natural peptide scaffolds. In this st...

Gok B, Budama-Kilinc Y, Kecel-Gunduz S

The increase in the aging population worldwide has led scientists to turn to research to prevent the aging process. In this context, synthetic peptides emerge as candidate molecules for developing new anti-aging products. This study aims to investigate the possible interactions of Syn-Ake, a synt...

Aires RS, Francisco da Silva Filho L, Gomes Rebello Ferreira LF, Hernandes MZ, Machado Marcondes MF, Carmona AK et al.

NPCdc is a natriuretic peptide synthesized from the amino acid sequence of the Crotalus durissus cascavella snake venom peptide, NP2Casca. NPCdc presents hypotensive and antioxidants effects. This study aimed to investigate in vivo whether angiotensin I-converting enzyme (ACE) inhibition would in...

Rádis-Baptista G

Cell-penetrating peptides (CPPs) comprise a class of short polypeptides that possess the ability to selectively interact with the cytoplasmic membrane of certain cell types, translocate across plasma membranes and accumulate in the cell cytoplasm, organelles (e.g., the nucleus and mitochondria) a...

Thankappan B, Angayarkanni J

Two cationic antimicrobial peptides (AMP) were designed based on the snake venom peptide, omwaprin, hypothesized to be shorter, cost effective and potent. Omw1 and omw2 demonstrated significant broad-spectrum antimicrobial activity against standard and clinical strains at a MIC ranging from 15.62...

Abdel-Ghani LM, Rahmy TR, Tawfik MM, Kaziri I, Al-Obaidi A, Rowan EG et al.

This study was conducted to examine the cytotoxic effects of Nubein6.8 isolated from the venom of the Egyptian Spitting Cobra Naja nubiae on melanoma (A375) and ovarian carcinoma cell lines and to reveal its mode of action. The size of Nubein6.8 (6801.8 Da) and its N-terminal sequence are ...

Yee KT, Pitts M, Tongyoo P, Rojnuckarin P, Wilkinson MC

Russell's viper bites are potentially fatal from severe bleeding, renal failure and capillary leakage. Snake venom metalloproteinases (SVMPs) are attributed to these effects. In addition to specific antivenom therapy, endogenous inhibitors from snakes are of interest in studies of new treatment m...

Kong Y, Wang Y, Yang W, Xie Z, Li Z

Based on the structure of AAP, a novel anti-thrombotic peptide from snake venom which we discovered in our previous study, more than 60 compounds were designed and synthesized. One of these termed as LX0702 exhibited stronger anti-platelet aggregation activity than AAP. This study aims to investi...

Camacho E, Villalobos E, Sanz L, Pérez A, Escalante T, Lomonte B et al.

A new homodimeric PII metalloproteinase, named BlatH1, was purified from the venom of the Central American arboreal viperid snake Bothriechis lateralis by a combination of anion-exchange chromatography, hydrophobic interaction chromatography, and gel filtration. BlatH1 is a glycoprotein of 84 kDa...

Okamoto DN, Kondo MY, Oliveira LC, Honorato RV, Zanphorlin LM, Coronado MA et al.

Snake venom metalloproteinases (SVMPs) belonging to P-I class are able to hydrolyze extracellular matrix proteins and coagulation factors triggering local and systemic reactions by multiple molecular mechanisms that are not fully understood. BmooMPα-I, a P-I class SMVP from Bothrops moojeni...

Akif M, Masuyer G, Bingham RJ, Sturrock ED, Isaac RE, Acharya KR et al.

Human somatic angiotensin-1 converting enzyme (ACE) is a zinc-dependent exopeptidase, that catalyses the conversion of the decapeptide angiotensin I to the octapeptide angiotensin II, by removing a C-terminal dipeptide. It is the principal component of the renin-angiotensin-aldosterone ...

Negraes PD, Lameu C, Hayashi MA, Melo RL, Camargo AC, Ulrich H et al.

Proline-rich peptides from Bothrops jararaca venom (Bj-PRO) were characterized based on the capability to inhibit the somatic angiotensin-converting enzyme. The pharmacological action of these peptides resulted in the development of Captopril, one of the best examples of a target-driven drug disc...

Wang SS, Zeng YL, Zhang WW, Dong SL

A bradykinin potentiating peptide (BPP), Thr-Pro-Pro-Ala-Gly-Pro-Asp-Val-Gly-Pro-Arg-OH, was isolated from the venoms of Crotalus viridis viridis (here named Cvv peptide). Compared with other BPP, Cvv peptide has special Thr at N-terminal and Arg at C-terminal. In order to clarify whether these t...