SS-31 Research

Lores-Arnaiz S

Aging and neurodegenerative diseases are characterized by common features involving bioenergetics deficiencies, oxidative stress and alterations of calcium buffering. Mechanisms of mitochondrial-targeted drugs include the modulation of electron transport chain and oxidative phosphorylation, the b...

Muscat SM, Deems NP, Alvarez BD, Butler MJ, Gonzalez Olmo BM, Kolonay DW et al.

Postoperative cognitive dysfunction (POCD) is a common and persistent complication in aging individuals following surgery, particularly when opioids are used for perioperative pain management. Although opioids are widely administered in the perioperative setting, the mechanisms by which they cont...

Xiong D, Zhang Y, Wei J, Wang L, Zhang G, Yu L et al.

Stavros S, Thomakos N, Moustakli E, Daponte N, Sioutis D, Kathopoulis N et al.

Crucial regulators of gamete metabolism and signaling, mitochondria synchronize energy generation with redox equilibrium and developmental proficiency. Once thought of as hazardous byproducts, reactive oxygen species (ROS) are now understood to be vital signaling molecules that provide a "redox w...

Schauer A, Jahn D, Vahle B, Barthel P, Männel A, Fabig G et al.

Mitochondrial dysfunction contributes to impaired myocardial energetics and performance in heart failure with preserved ejection fraction (HFpEF). Elamipretide (Ela) enhances mitochondrial bioenergetics in preclinical models, yet its relevance in HFpEF remains unclear. This study examined the eff...

Venkatesan S, Comi C, De Marchi F, Esposito T, Gramaglia C, Smirne C et al.

Severe emotional stress constitutes a significant public-health concern associated with negative health outcomes. Although the clinical effects are well acknowledged, the specific biological mechanisms that translate emotional suffering into systemic disease remain incompletely understood. Psycho...

Luo Y, Jiang P, Huang D, Li H, He J, Shen R et al.

Neural Stem Cells (NSCs) possess significant potential to form new neural networks. However, following spinal cord injury (SCI), mitochondrial dysfunction leads to the excessive accumulation of reactive oxygen species (ROS), which severely impairs the neuronal differentiation of endogenous NSCs a...

Nakagawa Y, Okazaki Y, Carballo CB, Wada S, Nemirov D, Selvaggio ER et al.

Tendinopathy is a significant source of pain and functional impairment, with contributions from various extrinsic and intrinsic factors. Prior studies have demonstrated the role of mitochondria (MT) dysfunction in a murine model of supraspinatus tendinopathy, with improvement in tendon structure ...

Li G, Li T, Deng Y, Deng X, Chen C, Yu B et al.

Heterotopic ossification (HO) is a common degenerative disease following trauma. Tendon HO is primarily attributed to osteogenic differentiation of stem/progenitor cells within the tendon. However, the precise mechanism underlying this process remains unclear. Recent studies suggest that PTEN ind...

Wang M, Liu C, Li Z, Wang Y, Li Y, Pei F et al.

Airway remodeling is a critical cause of chronic asthma that is difficult to control. Cell death contributes to the development and progression of chronic asthma. However, the novel copper-dependent cell death, cuproptosis, and especially cuproptosis of bronchial epithelial cells, its role, and u...

Bao W, Liu S, Du C, Liu J, Luo X, He Y et al.

Sarcopenia is a degenerative skeletal muscle disorder closely associated with aging, characterized by the gradual loss of muscle mass and function, which severely impacts the quality of life in the elderly. In general, the severity of sarcopenia varies significantly among different patients and a...

Vieira Neto E, Wang M, Szuminsky AJ, Ferraro L, Basu S, Zhao X et al.

Mitochondrial trifunctional protein (TFP) deficiency is an inherited disorder of long-chain fatty acid β-oxidation (FAO). TFP is a heteromeric enzyme composed of two α and two β-subunits. Despite early detection and dietary treatment, TFP deficiency patients often develop hypogl...

Mercola J

Conventional nutritional supplements frequently demonstrate limited clinical effectiveness due to the harsh milieu of the gastrointestinal tract, inefficient trans-epithelial transport, and rapid systemic clearance. Nanoliposomal delivery platforms - lipid bilayer vesicles on the nanometer scale ...

Li M, Gu Q, Fan Z, Duan C

Spinal cord injury (SCI) is a major public health challenge, often leading to severe neurological and physical disabilities. Microglia, the primary immune cells in the spinal cord, play critical roles in both the physiology and pathology of SCI. A deeper understanding of microglial activation is ...

Tamucci JD, Zweifach A, Alder NN, May ER

Several studies have used molecular dynamics (MD) simulations to examine the relationship between transmembrane potentials (ΔΨm) and electroporation; however, research on how this relationship presents in complex membranes with heterogeneous lipid compositions is limited. Here, we use...

Shirley M

Elamipretide (Forzinity™) is a mitochondrial cardiolipin binder being developed by Stealth BioTherapeutics for the treatment of a range of disorders featuring mitochondrial dysfunction. In September 2025, elamipretide was granted accelerated approval in the USA for use to improve muscle st...

Du W, Jiang Y, Wu L, Liang Y, Wu YP, Liu H et al.

Mitochondrial dysfunction is a hallmark of early diabetes. Previous studies suggest that Argonaute-2 (AGO-2) supplementation enhances mitochondrial gene expression and improves cellular stability. Here, we investigated AGO-2 expression during diabetic myocardial injury and designed a multifunctio...

Marjoram L, Huang Y, Koenig MK, Cohen BH, Anderson E

Barth syndrome (BTHS) is an ultra-rare, X-linked genetic disorder for which there is limited economic data. Because compiling such data that target rare indications is difficult, we assessed real-world data to increase understanding of the cost of BTHS based on disease burden and health care reso...

Zhao C, Zhuang X, Gao J

Barth syndrome (BTHS) is a rare X-linked mitochondrial disorder caused by tafazzin mutations that impair cardiolipin remodeling, leading to mitochondrial dysfunction and symptoms such as cardiomyopathy, myopathy, and neutropenia. On September 19, 2025, the U.S. Food and Drug Administration (FDA) ...