Somatostatin Research

Yamane T, Kazuta N, Nakashima K, Watanabe H, Ono M

Somatostatin receptor 2 (SSTR2) is a valuable target for the treatment of patients with neuroendocrine tumors (NETs). [177Lu]-Lu-DOTA-TATE, an SSTR2-targeted ligand, is clinically used for therapy in patients with NETs; however, a low-absorbed dose in tumors remains a limitation. Albumin binders ...

Slott C, Langer SW, Oturai P, Møller S, Hansen CP, Kjaer A et al.

Small intestinal neuroendocrine tumors (siNET) are rare malignancies, often diagnosed at advanced stages with metastatic spread. While surgery is the only curative treatment, medical therapies, including somatostatin analogues (SSA), peptide receptor radionuclide therapy (PRRT), and other systemi...

Zueva A, Loh EW, Masuka S, Wadsley J, Newell-Price J, Munir A et al.

Parathyroid hormone-related peptide (PTHrP)-secreting pancreatic neuroendocrine tumours (Pan-NETs) are a rare cause of humoural hypercalcaemia of malignancy (HCM). We report two contrasting cases of metastatic well-differentiated PTHrP-secreting Pan-NETs (WHO grade 2; Ki-67: 7 and 8%, respectivel...

Richevaux L, Fischer R, Baid M, Shepherd GMG

Communication from secondary (M2, premotor) to primary (M1) motor cortex is implicated in forelimb motor control. We investigated the underlying synaptic circuits in this corticocortical pathway in male and female mice using cell-type-specific optogenetic-electrophysiology methods, focusing on id...

Hendricks WD, Sadahiro M, Mossing D, Veit J, Adesnik H

Mapping neural computation onto the functional microarchitecture of sensory circuits is essential for understanding how brain circuits transform input signals into coherent percepts. Many higher-order perceptual processes emerge in the cortex, yet relatively little is known about how specific con...

Degryse L, Teles L, De Vleeschouwer S, Boeckxstaens L, Jentjens S, Deckers W et al.

This study aims to evaluate differences in PET/CT imaging of meningioma using both gallium-68- and fluorine-18-labelled somatostatin receptor (SSTR) tracers, to characterize incidentally detected meningiomas on SSTR PET/CT, and to analyse institutional experience with Peptide Receptor Radionuclid...

Zhao Y, Tao Y, Zhu Y, Li S, Guo H, Huang Y et al.

Vo TT, Kim SG

fMRI signals arise from interactions among multiple cell types, complicating their interpretation. While excitatory neurons are often considered primary drivers, inhibitory neurons and astrocytes also modulate hemodynamic responses but remain less explored. We show that somatostatin-expressing (S...

Chen XX, Han XF, Chu Y

Cerebral infarction (CI) is a major subtype of ischemic stroke, with high incidence, recurrence rate, disability rate, and mortality rate in the elderly. Elderly CI patients are prone to peptic ulcer due to long-term use of antiplatelet drugs and stress factors, which further leads to gastrointes...

Gujral J, Gandhi OH, Amanullah AA, Singh SB, Ayubcha C, Patil S et al.

Meningiomas account for 41.7% of primary central nervous system (CNS) tumors and overexpress somatostatin receptor 2 (SSTR2) receptors, enabling superior tumor-to-background contrast compared with MRI and computed tomography imaging, which have limited ability to distinguish neoplastic tissue fro...

Virgolini IJ, Di Santo G, Santo G

Peptide receptor radionuclide therapy (PRRT) has established itself as a pivotal component in the management of advanced, somatostatin receptor (SSTR)-positive neuroendocrine tumours (NETs). The NETTER-1 phase III trial demonstrated that [177Lu]Lu-DOTATATE significantly prolongs progression-free ...

Malinochka A, Khupsergenov E, Avagyan A, Kurachenko Y, Britan I, Hvorostova S et al.

Acromegaly is a chronic neuroendocrine disorder caused by excessive secretion of growth hormone and insulin-like growth factor-1, leading to systemic metabolic and organ dysfunction, substantial comorbidity, and an increased risk of premature mortality. This article presents a clinical case of a ...

Goode TD, Bernstein MX, Totty MS, Alipio JB, Vicidomini C, Pathak D et al.

Contextual encoding in the dorsal hippocampus (DHPC) may recruit hypothalamic feeding modules to calibrate eating across environments, but the mechanistic instantiation of cells and circuits that undergird these processes is limited. Single-cell transcriptomics and transsynaptic tracing of the do...

Abadi Chiriti J, Castañeda Gaxiola R, Rodriguez Alvarado M, Marquina Ramírez ME, Arias Gomez E, Gomez Olvera BP et al.

Chylous ascites is a rare condition characterized by the accumulation of lipid-rich lymph within the peritoneal cavity. While typically secondary to malignancy or trauma, its occurrence following laparoscopic inguinal hernia repair is exceptional. While clinical findings are usually sufficient to...

Kobayashi N, Ono H, Okubo N, Akahoshi K, Kudo A, Ban D et al.

Peptide receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogs is an innovative treatment for advanced well-differentiated neuroendocrine tumors (NETs). In Japan, PRRT with Lutetium-177 oxodotreotide (177Lu- oxodotreotide) was recently approved following Phase I and Phase I/I...

Yi M, Shen Q

Campos Cardoso R, Franks HT, Potter NR, Desa ZR, Fitzgerald BL, Fowler RL et al.

The ability for an organism to encode fear memories is necessary for survival. Once a threat is no longer present, organisms must suppress, or extinguish, this fear memory in favor of other adaptive behaviors. In rodents, the infralimbic cortex (IL) is a locus critical for the extinction of cued ...

Richevaux L, Fischer R, Baid M, Shepherd GMG

Communication from secondary (M2, premotor) to primary (M1) motor cortex is implicated in forelimb motor control. We investigated the underlying synaptic circuits in this corticocortical pathway in male and female mice using cell-type-specific optogenetic-electrophysiology methods, focusing on id...

Liu Z, Li Y, Duan K, Chi H, Cui Y

To analyze the clinical effect of ulinastatin (UTI)-somatostatin (SS) combination on acute severe pancreatitis (SAP) patients, focusing on changes in efficacy and serum inflammatory markers (IMs).This study retrospectively enrolled 104 SAP patients (July 2022-July 2025), with 51 patients (control...

Chen X, Guo S, Li YG, Liu AK, Kuang J, Shi P et al.

Somatostatin receptor 3 (SSTR3) exerts critical biological functions such as negatively regulating hormone release and cell proliferation, making it a promising therapeutic target for endocrine disorders and nonfunctioning pituitary tumors. However, the development of more effective and safer som...