Selank Research

Han D, Chen CY, Huang X, Liu Y, Sun H, Li Y et al.

Androgen and TGF-β1/Smad signaling pathways play important roles in epithelial-mesenchymal transition (EMT), fibrosis, and the development of benign prostatic hyperplasia (BPH). Cinnamophilin is extracted from Cinnamomum philippinense. The anti-proliferative and anti-fibrosis effects of cin...

Rahman OF, Lee SJ, Seeds WA

Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine. By acting on key pathways such as PI3K/Akt, mTOR, MAPK, TGF-β, and AMPK, peptides exert influen...

Contreras-Lopez L, Clavero FI, Hurtado Restrepo PA, de Arriba NP, Álvarez AD, Montes Armenteros JA et al.

There are no optimized patient blood management (PBM) protocols for brain tumor resection (BTR). The aim of this study was to compare the prevalence of packed red cells (PRCs) units reserved with the prevalence of transfusion during BTR and analyse preoperative anemia.Prospective observational mu...

Zhang W, Ling J, Lan L, Guo Q, Ruan Y, Wu D et al.

This study explored relationship between concentrations of perchlorate, nitrate, and thiocyanate and serum liver function markers using data from 3366 adults in the 2013-2018 National Health and Nutrition Examination Survey (NHANES) of the United States. Generalized linear model (GLM), restricted...

Liu X, Mao W, Zhao G, Liao J, Li Q, He G et al.

To investigate the combined effects of oral nutritional supplement (ONS) and intestinal microecology on postoperative nutrition status, inflammatory response and intestinal flora regulation colorectal cancer (CRC) patients.This prospective single-center randomized controlled trial (RCT) was condu...

Chulanova AA, Smakhtina AM, Mal GS, Bobyntsev II, Smakhtin MY, Mishina ES et al.

We studied the reparative and antioxidant effects of thymogen (10 and 100 μg/kg) and its modifications in equimolar doses (12 and 120 μg/kg) obtained by attaching the amino acid D-alanine (D-Ala) to the N- or C-terminus of the peptide molecule. A single intraperitoneal injection of hy...

Kozłowski M, Papaj B, Sobieraj K, Świechowski K, Kosiorowska K, Białowiec A et al.

Anaerobic digestion (AD) is a useful process that could be utilized for food waste (FW) management. Previous studies have shown that carbon materials (CMs) could be an important additive for increasing biomethane yield. However, why CMs improve AD is still uncertain. A significant body of researc...

Liu X, Mao W, Zhao G, Li Q, Liao J, He G et al.

This clinical study combined alanyl-glutamine and omega-3 polyunsaturated fatty acids (ω-3 PUFAs) to investigate the effects of parenteral nutrition on postoperative inflammation and nutritional status in patients with gastroduodenal perforation to provide a basis and support for the use of...

Justin LD, Olukanni DO

Three aquatic macrophytes were used to treat wastewater using a pilot-constructed wetland (CW) system to determine the most efficient plants for removing contaminants from wastewater. The three macrophytes are water hyacinth (Eichhornia crassipes), water lettuce (Pistia stratiotes), and duckweed ...

Yang C, Ge X, Ge C, Zhao P, Liang S, Xiao Z et al.

Five polypeptides with a potential umami taste were isolated and purified from Yanjin black bone chicken. However, the flavor characteristics and umami mechanism have not been clarified. The umami properties of these five peptides were investigated in this work using a range of analytical techniq...

Shimoda M, Nunokawa H, Tanaka Y, Morimoto K, Moue I, Yoshimori K et al.

In patients with interstitial lung disease (ILD), the risk of pulmonary embolism (PE) is increased; however, distinguishing between PE and ILD exacerbation can be difficult. Therefore, this study investigated the usefulness of the Wells criteria and revised Geneva score and predictive factors for...

Seibertz F, Rubio T, Springer R, Popp F, Ritter M, Liutkute A et al.

Atrial fibrillation (AF) is associated with tachycardia-induced cellular electrophysiology alterations which promote AF chronification and treatment resistance. Development of novel antiarrhythmic therapies is hampered by the absence of scalable experimental human models that reflect AF-associate...

Gudipati S, Shallal A, Peterson E, Cook B, Markowitz N

We observed an increase in the frequency of false-positive (FP) human immunodeficiency virus (HIV) test results that correlated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) prevalence. We measured FP rates of laboratory-based fourth-generation HIV antigen/antibody test among ...

Ayaz M, Khan R, Khan S, Suhail SM, Khan K, Ahmad I et al.

Frass is the main component of worm by-product which exhibit anti-microbial and anti-pathogenic properties. In the present study, we assessed the possibility of mealworm frass in sheep feeding regime and evaluated its effect on health and growth performance of sheep. A total of 09 experimental sh...

Jiang X, Zhang W, Ma X, Cheng X

Background: Thrombocytopenia (TP), a common occurrence among patients admitted to the intensive care unit (ICU), is significantly associated with prolonged ventilator use, prolonged ICU stay, and increased mortality. The duration of TP serves as an indicator of patient outcome, although the exact...

Konstantinopolsky MA, Chernyakova IV, Kolik LG

Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipitated morphine withdrawal model. Single intraperitoneal injection of Selank in an anxiolytic dose of 0.3 mg/kg reduced the total index of morphine withdrawal syndrome by 39.6%, significantly (&#x44...

Syed SN, Brüne B

MicroRNAs have been projected as promising tools for diagnostic and prognostic purposes in cancer. More recently, they have been highlighted as RNA therapeutic targets for cancer therapy. Though miRs perform a generic function of post-transcriptional gene regulation, their utility in RNA therapeu...

Nualkul M, Yuangsoi B, Hongoh Y, Yamada A, Deevong P

The present study aimed to isolate and characterize proteolytic Bacillus spp. from termite guts to test the possibility of application for improving the nutritional value and bioactivity of fermented soybean meal (FSBM). Aerobic endospore-forming bacteria were isolated from the gut of the termite...

Bruhnke M, Wierichs RJ, von Stein-Lausnitz M, Meyer-Lückel H, Beuer F, Naumann M et al.

The objective of this prospective clinical study was to investigate survival for endodontically treated teeth restored with adhesively luted prefabricated dentinlike or rigid posts.Data were recorded for glass-fiber posts (GFPs) and compared with historical controls evaluating glass-fiber (GFP I)...

Doyno CR, White CM

There are many nonopioid central nervous system depressant substances that share a gamma-aminobutyric acid (GABA) receptor-related mechanism of action. These sedatives-hypnotics can be indicated to treat anxiety, seizures, depression, and insomnia but are also used as substances of abuse and used...