Secretin Research

Li S, Li H, Jin S, Zeng J, Dong J

The sphincter of Oddi (SO), as the critical bidirectional regulatory valve structure of the pancreatobiliary system, still requires extensive research regarding its functional assessment and dysfunction repair. This systematic review examines SO regulatory mechanisms, diagnostic approaches for dy...

Tzeravini E, Simati S, Anastasiou IA, Dalamaga M, Kokkinos A

The gastrointestinal tract acts as an endocrine organ, releasing hormones that regulate glucose homeostasis, appetite, energy expenditure, and gastrointestinal motility. In type 2 diabetes (T2DM) and obesity, this finely tuned hormonal system is disrupted, contributing to metabolic dysfunction. T...

Siddappa PK, Kong N, Lee A, Jiang Y, Park WG

Pancreatic juice (PJ) analysis has emerged as a promising modality for the diagnosis of pancreatic diseases, particularly pancreatic ductal adenocarcinoma and chronic pancreatitis. This review explores the role of PJ analysis in identifying biomarkers for the early detection and differentiation o...

Glenn AO, Dudley JA, Abu-El-Haija M, Vitale DS, Trout AT

Magnetic resonance imaging (MRI) with secretin stimulation allows non-invasive assessment of pancreatic secretion in vivo. Software (PFTquant) can facilitate quantification of secretory response. Our objective was to quantify secretory response for a clinical sample of pediatric patients and comp...

Ramos-Álvarez I, Mantey SA, Jensen RT

Serine/threonine phosphatase 1 (PP1) and phosphatase 2A (PP2A) play important roles in mediating cellular signaling in different tissues to different stimuli, including in protein synthesis, growth, cell cycle regulation, and secretion. However, their roles in various pancreatic exocrine function...

Wallace MB, Majumder S, Storz P, van Hooft JE

Endoscopic ultrasound (EUS) has evolved from a diagnostic imaging tool into a versatile platform that enables high-precision access, sampling, and therapy across gastrointestinal and hepatobiliary diseases. This review summarizes recent advances that are reshaping diagnostic practice and theragno...

Heinonen S, Karppinen JE, Saarinen T, Groop PH, Juuti A, Holst JJ et al.

Few studies have compared gut hormone responses between bariatric procedures. This study compared Roux-en-Y and one-anastomosis gastric bypass (RYGB and OAGB) regarding glucagon-like peptide-1 (GLP-1), secretin, and glucose-insulin dynamics.This study included 41 participants (RYGB: n =&#x...

Expert Panel on Gastrointestinal Imaging, Gupta A, Chernyak V, Chang KJ, Bhosale PR, Cash BD et al.

Chronic pancreatitis (CP) is a progressive disorder of the pancreas characterized by irreversible parenchymal and ductal changes, leading to chronic pain and pancreatic insufficiency. Its impact on quality of life can be profound and may further be complicated by acute inflammation superimposed o...

Ideno N, Hanada K, Tokunaga S, Ohtsuka T, Mori Y, Hara K et al.

Establishing an effective screening method for pancreatic ductal adenocarcinoma (PDAC) is important. This study re-evaluated the diagnostic utility of the duodenal fluid (DF) marker S100 calcium-binding protein P (S100P) during upper gastrointestinal endoscopy (GIE).Study 1 and Study 2 prospectiv...

Morash M, Kay RG, Soderblom EJ, MacLean GH, Wen J, Moore PJ et al.

Enteroendocrine cells (EECs) are rare sensory cells in the intestinal epithelium that coordinate digestive physiology by secreting a diverse repertoire of peptide hormones. These hormones are the main effectors of EEC function, and their characterization requires direct observation by mass spectr...

Roberts CS, Gura C, Sandkvist M

Gram-negative bacteria employ the type II secretion system (T2SS) to not only secrete an array of soluble effectors, such as toxins, to the extracellular space, but also to facilitate the surface localization of enzymes and adhesins that are beneficial to life in different environments. For examp...

Venkatakrishna SSB, Onyango LC, Acord MR, Srinivasan AS, Lerebo WT, Khrichenko D et al.

Exocrine pancreatic insufficiency (EPI) can be assessed noninvasively using magnetic resonance cholangiopancreatography (MRCP) with secretin stimulation. This pilot study measured pancreatic volumes in children with suspected EPI and quantified total secreted fluid volume after secretin stimulati...

Zhang F, Tao Z, Nawabjan SA, Xiang M, Deng X, Li Y et al.

Obesity necessitates effective therapeutics targeting energy-regulating pathways. Secretin (SCT) shows therapeutic promise but is limited by its short half-life and lack of potent agonists. We investigated purmorphamine, a small-molecule modulator of the SCT receptor (SCTR), for its ability to en...

Tsukui M, Yagishita S, Tokunaga S, Wakatsuki S, Araki T

Autism spectrum disorder (ASD) is a neurodevelopmental disorder typically characterized by impaired social communication. Previous reports have postulated gut microbiota to be an important non-genetic factor affecting ASD-like phenotypes in mice, as germ-free (GF) mice show impaired social commun...

Bartlett AM, Blair PJ, Sanders KM, Baker SA

Secretin is a gastrointestinal (GI) hormone that slows intestinal motility, an effect thought to be mediated through vagal afferent pathways. In this study we show evidence for a novel function of secretin involving a non-neural mechanism mediated by interstitial cells of Cajal (ICC). Transcripts...

Mahajan N, Lal R, Kumar V, Khare P, Baboota RK, Rana P et al.

Enteroendocrine cells (EECs) in the gastrointestinal tract play a critical role in sensing dietary fat and regulating the secretion of gut hormone. However, chronic high-fat diet (HFD) intake can lead to maladaptive changes in these cells, impairing hormone regulation. Transient receptor potentia...

Liu R, Feng Q, Zhang K, Dai X, Dai J, Guo X et al.

Dual-constriction nanopores offer a second sensing region that enhances the interactions with analytes at the single-molecule level. However, existing biological nanopore complexes, i.e., CsgG-CsgF, are prone to dissociation upon high voltages, enforcing the development of robust "one-take" platf...

Pei C, Sun H, Qi Y, Li X, Fang Z, Tang M et al.

The bundle-forming pilus (BFP) system in enteropathogenic Escherichia coli (EPEC) produces type IVb pili that enable bacterial auto-aggregation, facilitating bacterial adhesion, colonization, and virulence. One of its components, lipoprotein BfpB, interacts with BfpG to form a secretin channel co...

van de Pavert YL, Kastelijn JB, Besselink MG, Booij DC, Boonstra JJ, Boot J et al.

In patients with malignant gastric outlet obstruction, endoscopic ultrasonography-guided gastroenterostomy might be superior to surgical gastroenterostomy, but randomised trials are scarce. We aimed to assess time to resumption of oral intake and the rate of persistent or recurrent obstructive sy...

Jeong SH, Kim YJ, Shin JY, Oh KW, Lee JW, Lee PH et al.

Dipeptidyl peptidase-4 inhibitors (DPP-4is) have been reported to exhibit therapeutic effects in Parkinson's disease (PD), increasing their potential for drug repurposing. One aspect of PD pathogenesis is thought to be associated with the gut-brain axis, where α-synuclein from the gut is tr...