Peptide YY Research

Dobbs TJ, Pyle L, Moore JM, Garrish J, Behn CD, Weissenkampen D et al.

This study evaluated impacts of vertical sleeve gastrectomy (VSG) on glycemic and cardiometabolic outcomes in youth-onset type 2 diabetes (YO-T2D).Pre- and postoperative (3 and 12 months) anthropometrics, mixed-meal tolerance test (MMTT) and body composition assessments, and hyperglycemic ...

Joo SS, Gu BH, Lee E, Oh E, Kim M, Jung H et al.

Intestinal epithelial cell lines have been widely used in the field of biomedical and livestock research, and recently, the use of organoid systems has been attempted. However, they have several limitations as an in vitro platform in particularly in nutrition-related studies. Thus, this study aim...

Brown A, Wingrove J, Flint SW

Experimental evidence indicates that exposure to weight stigma can lead to sustained elevations in cortisol and ambulatory blood pressure. However, little is known about its acute effects on other physiological markers. This study aimed to explore the feasibility of measuring the physiological re...

Ergani AC, Tezcan ME, Can Ü, Arslan Kılıçoğlu E

Malnutrition and sleep disturbances are common in childhood and are associated with neuropeptides that regulate appetite and circadian rhythms. Hypothalamic peptides such as orexin A, agouti-related protein (AgRP), proopiomelanocortin (POMC), and peptide YY (PYY) play important roles in energy ba...

Borner T, Pataro AM, Curtis GR, Alonso B, Hu J, Fortin SM et al.

The induction of nausea and emesis represents a significant barriers to optimizing weight loss medications for the treatment of obesity. Identifying mechanisms that improve tolerability and/or enhance efficacy without induction of emetic neurocircuitry could provide substantial therapeutic benefi...

Han N, Tian X, Shen Z, Wang L, Zhu H, Zhao Y et al.

This study elucidates the antiobesity mechanism of the Fu brick tea extract-millet complex (FTE-M). FTE-M exhibited a dense and smooth microstructure, resulting in improved digestive properties compared with millet alone, including a reduced glycemic index and increased slowly digestible starch a...

Bæch-Laursen C, Ucin JV, Galsgaard KD, Llana J, Kissow H, Rehfeld JF et al.

Physical activity helps maintain a healthy stable body weight. One mechanism underlying this beneficial effect could be the improved coupling between energy intake and expenditure, since hunger and satiety are better regulated in active individuals. Whether this enhancement of appetite control by...

Yun L, Li S, Zhao T, Zhang J, Siriwattananon L, Zhang M et al.

Most consumers exhibit a preference for spicy substances; however, the metabolic complexities and health impacts associated with these substances-capsaicin (from chili), allicin (from garlic), and 6-gingerol (from ginger)-remain largely unexplored. This study evaluated the effect of dietary capsa...

Tzeravini E, Simati S, Anastasiou IA, Dalamaga M, Kokkinos A

The gastrointestinal tract acts as an endocrine organ, releasing hormones that regulate glucose homeostasis, appetite, energy expenditure, and gastrointestinal motility. In type 2 diabetes (T2DM) and obesity, this finely tuned hormonal system is disrupted, contributing to metabolic dysfunction. T...

Bullich-Vilarrubias C, Romaní-Pérez M, López-Almela I, Pomares-Díaz C, Franzin SB, Esposito G et al.

Excess energy intake contributes to adiposity in obesity. We investigated whether the human intestinal bacterium Phascolarctobacterium faecium could prevent obesity via enteroendocrine pathways in a mouse model of diet-induced obesity (DIO). Daily administration of P. faecium (2 ×&#x2...

Muzurović E, Katsiki N, Volčanšek Š, Plescia F, Rizzo M, Mantzoros CS et al.

While the use of glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) has achieved a central position in our therapeutic armamentarium, new and innovative incretin- and multi-agonist-based treatment strategies hold further promise as potential game-changers for obesity and cardio-kidney-liver-...

Baugh AT, Partecke J, Wellbrock N, Frias-Soler RC, Bairlein F, Hykollari A et al.

Migratory birds expend substantial energy during flight and often rely on stopovers to refuel. Foraging behavior during stopover might vary with fuel loss and food availability though likely involves higher food intake rates than in non-migratory (resident) individuals. In mammals, hormones such ...

Le Calvez F, King J, Couret A, Abergel A, Thivel D, Ennequin G et al.

Malnutrition is highly prevalent in end-stage liver disease (ESLD), while being strongly associated with sarcopenia and poor prognosis in this population. The physiological regulation of energy intake is influenced by tonic signals, reflecting body composition and metabolic demands, and episodic ...

Holliday A, Barrett M, Cox NJ

Anorexia of ageing - the age-related reduction in appetite and food intake - is a public health concern for an ageing global population. However, current understanding of the aetiology of the condition is limited. In this review, evidence of gut hormone responses to feeding in older adults is rev...

Schüß C, Vu O, Pelczyk T, Schubert M, Du Y, Stichel J et al.

The neuropeptide Y4 receptor (Y4R) and its endogenous ligand pancreatic polypeptide (PP) are primarily involved in the regulation of satiety and energy balance and present relevant pharmacological targets. We characterized the novel Y4R positive allosteric modulator C1 that enhances Y4R G-protein...

Malin SK, Heiston EM

Allostatic load is a physiological measure of chronic stress, and stress is implicated in disrupting appetite regulation. Individuals with obesity and type 2 diabetes have higher allostatic load compared to lean counterparts. However, whether allostatic load differs across prediabetes phenotypes ...

Baldassano S, Di Rosa L, Cortis C, Cannizzaro A, Fiore AS, Sabatino L et al.

Background/Objectives: Excessive sugar, fat, and salt intake heighten susceptibility to metabolic syndrome and other chronic metabolic conditions. Biofortification (i.e., enhancing the nutritional content of crops) emerges as a sustainable new approach to address dietary deficiencies. Methods: Th...

van Beijsterveldt IALP, Dorrepaal DJ, van Zelst BD, van Vark-van der Zee LC, Mulder MT, van den Berg SAA et al.

The non-degradable poly- and perfluoroalkyl substances (PFAS) are 'Endocrine Disrupting Chemicals' (EDCs), a group of chemicals that interfere with endocrine processes in the human body and potentially have adverse effects on several developmental domains in children. Particularly when PFAS expos...

Thapa G, Barbhuiya PA, Pathak MP

Obesity has emerged as a worldwide health issue because of sedentary lifestyles, inadequate nutritional practices, and metabolic dysfunction. Traditional anti-obesity medications, although efficacious, often exhibit considerable adverse effects, resulting in their market removal. Consequently, th...

de la Monte SM, Tong M, Yang Y

Alcohol's chronic neurotoxic and degenerative effects mediate alcohol-related brain damage (ARBD), which is marked by neurobehavioral, cognitive, and motor deficits. Major underlying abnormalities include impairments in signaling through the insulin and insulin-like growth factor (IGF) pathways, ...