Progeline Research

Hart LN, Errera R, Godwin C, Loftin KA, Laughrey ZR, Katona LR et al.

Toxic cyanobacterial harmful algal blooms (cyanoHABs) threaten freshwater resources globally and are intensifying with increasing eutrophication. Bloom toxicity is strongly influenced by intraspecific variation in the biosynthetic repertoires of toxic cyanobacteria, yet few studies examine the di...

Taruta H, Tanaka T, Kaneko MK, Suzuki H, Kato Y

The CXC chemokine receptor 2 (CXCR2) is a member of the G-protein-coupled receptor superfamily and regulates a diverse range of immune responses and tumor progression. CXCR2 is expressed on immune cells, especially neutrophils, and is involved in various immune responses by interacting with its c...

Wang D, Liu Y, Zeng YH, Jiang XD, Cui WH, Suo ZQ et al.

Rose represents the most traded cut flowers worldwide with enormous diversity in floral organs, especially petal number, a target trait during modern rose breeding. With a detailed phenome analysis, we here report the high variation pattern in floral organ number among 132 rose lines, including w...

Chakraborty A, Roy S

Solvation dynamics play a central role in shaping nucleic acid structure, flexibility, and recognition, yet their molecular origins remain poorly understood for RNA, whose diverse architectures and intrinsic conformational plasticity far exceed those of DNA. Here, we present the atomistic, micros...

Haugen HJ, Sanz J, Perale G, Saiz AM, Romandini M, Rahmati M et al.

Bone substitute biomaterials have become a sine qua non in periodontology and implant dentistry; however, the ideal material choice remains controversial. In this review, we examine natural grafts (autograft, allograft, xenograft) and synthetic grafts (alloplasts, composites, CAD-CAM personalised...

Papa A, Balzan S, Lubrano V, Sabatino L

Atherosclerosis and diabetes are largely recognized as inflammatory disorders underlying cardiovascular disease. C-reactive protein, interleukin-6 and fibrinogen constitute the most established inflammatory biomarkers in clinical practice for the characterization of individuals affected by athero...

Wilson KJ, Esteban-Lopez M, Myhr C, Ye W, Moore CE, Southall N et al.

A dose-response quantitative high-throughput screening of 147,334 small molecule compounds using a human Relaxin/Insulin-like Family Peptide Receptor 2 (RXFP2)-transfected HEK293T-RXFP2 cell line identified compound 5 with modest Insulin-Like3 (INSL3) agonist activity. An extensive structure-acti...

Pramanik A, Rani R, Jha B, Pramanik DD, Mishra P

Targeted delivery of chemotherapeutic agents can reduce systemic toxicity and enhance therapeutic outcomes by increasing the level of drug accumulation at tumor sites. In this study, we developed lipid-based cubosomal nanocarriers with an optimal size of 157 ± 20 nm for effective tumor penet...

Hughes S, Cheong J, Snape J, Jethwa S, Ng SH, Thangarajah R et al.

Teicoplanin exhibits complex pharmacokinetics with substantial inter-patient variability. Therapeutic drug monitoring (TDM) is recommended to ensure adequate exposure, yet contemporary data on real-world prescribing practices are scarce. We evaluated current teicoplanin dosing and monitoring prac...

Yu M, Fu J

Fibrosis is a major cause of biomedical device failure. Recent advances identify SPP1+ macrophages as pivotal regulators of this process. These cells derive from CCR2+ monocytes, adopt a lipid-associated macrophage-like phenotype, and terminally differentiate within collagen-rich niches at implan...

Qin W, Li Z, Fu G, Li Y, Huang W, Yu M et al.

Interleukin (IL)-38 has been recently identified as an anti-inflammatory cytokine. Polymyositis (PM) and dermatomyositis (DM) are two prevalent clinical inflammatory myopathies. This study aims to investigate the serum concentrations of IL-38 in patients with PM/DM and their association with thes...

Danzer B, Andersen G, Kahlenberg K, Somoza V

Excessive cytokine production is a major complication in severe COVID-19. Treatment with antiviral drugs often elicits a bitter taste through activation of bitter taste receptors (TAS2Rs). Since ectopically expressed TAS2Rs can alter cytokine secretion, we hypothesized that homoeriodictyol (HED),...

Huang Y, You Q, Yao T, Tong Y, Yang X, Zhang X et al.

Inflammatory bowel disease (IBD) remains a critical unmet medical challenge, with a substantial number of patients experiencing ineffective treatment or therapeutic failure over time. Here, GB20-5A8-31, a novel anti-TNF-like ligand 1A (TL1A) antibody, was engineered for high potency and superior ...

Koutsouveli V, Torres-Oliva M, Marulanda-Gomez AM, Franke A, Fuß J, Schmitz RA et al.

Porifera, one of the earliest diverging metazoans, have shown a surprisingly complex immune repertoire. However, most information to date is based on de novo transcriptome assemblies, limiting our knowledge regarding the presence and evolution of poriferan immune repertoire. Here, we generated th...

Lv Y, Jin YL, Zhou Z, Liao JB, Zhang ZQ, Tang LY et al.

Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), has an important pathogenesis that lies in the self-amplifying inflammatory circuit formed by bidirectional interactions between dendritic cells (DCs) and T follicular helper (TFH) cells. This review ...

Szaryńska M, Olejniczak-Kęder A

Bradykinin (BK) is a biologically active nanopeptide that plays a crucial role within the kallikrein-kinin system (KKS), a complex network involved in the regulation of vascular tone, epithelial cell ion transport, vascular permeability, mucosal secretion, release of cytokines from leukocytes amo...

Shen A, Zhu S, Li M, Zhao Y, Wu Y, Zhang Y et al.

To evaluate the synergistic immunological protection of exosomal T-cell epitope vaccine and antibody-inducing vaccine against SARS-CoV-2 in highly humanized mice.Red blood cell-derived exosomes were loaded with 27 CD8+ T-cell epitope peptides and 19 CD4+ T-cell epitope peptides followed by combin...

Espinoza-García N, Palafox-Sánchez CA, De Arellano AR, Salazar-Camarena DC, Rocío Félix-Murray K, Marín-Rosales M et al.

SLE is a chronic autoimmune disease characterized by immune system dysregulation, including aberrant activation of B and T lymphocytes and overproduction of proinflammatory cytokines such as IL-21. Through the STAT3 signaling pathway, this cytokine plays a key role in SLE-promoting autoantibody p...

Nami Y, Barghi A, Sadeghi M, Farhadi T, Haghshenas B

Lactobacillus delbrueckii is a key lactic acid bacterium (LAB) widely used in dairy fermentation, particularly in the production of yogurt, cheese, and kefir. Its metabolic activities-such as efficient lactose utilization, rapid acidification, and high proteolytic activity-make it an indispensabl...

Maroof K, Lee RFS, Karacabey P, Genç R

Liver fibrosis and hepatocellular carcinoma (HCC) remain major global health burdens, in part due to limited drug specificity, off-target toxicity, and the complex hepatic microenvironment. Peptide-functionalized liposomal nanocarriers have emerged as a promising approach to enhance cell-selectiv...