Polymyxin B Research

Qamar FN, Siddiqui S, Adegbola R

Antimicrobial resistance (AMR) is a growing global health crisis, threatening decades of progress in infectious disease control. Without urgent intervention, AMR could lead to 10 million deaths annually by 2050. Vaccination is a powerful yet underutilized tool in the fight against AMR, as it prev...

Oyetunji OE, Odebode AC, Nwilene FE, Kotun BC, Thonda OA, Aransiola SA et al.

Orseolia oryzivora (African Rice Gall Midge-AfRGM) infestation remains a critical problem of rice in lowland agro-ecologies in Sub-Saharan Africa. Substantial and increasing yield losses caused by AfRGM are putting food security at stake in the affected areas. Insecticide application is not ecofr...

Gericke FC, Hanson JVM, Hackenberg A, Gerth-Kahlert C

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare autoimmune disease affecting the central nervous system, frequently manifesting with optic neuritis (ON). Despite often favourable functional visual recovery, structural retinal changes may persist. This prospective...

Feng M, Wu X, Hu X, Wu Y, Gou S, Ran Q et al.

Antibiotic resistance has emerged as a critical global public health challenge. Quorum sensing (QS), a density-dependent regulatory mechanism, plays a pivotal role in bacterial pathogenesis by coordinating virulence factor expression, making it a critical target for antivirulence therapy. Leverag...

Amoako N, Cohuet S, Adjei MR, Gurry C, Oduro A, Agyapong PD et al.

The use of vaccines to urgently respond to the COVID-19 pandemic generated the need for monitoring vaccine effectiveness in the context of new viral variants and changing epidemiology. This study measured the COVID-19 vaccine effectiveness (VE) against laboratory-confirmed SARS-CoV-2 in hospitali...

Cutarella L, Temprano AG, Tafi A, Mori M

The rapid spread of antimicrobial resistance (AMR) has relaunched Colistin A, a member of the polycationic polymyxin (PMBs) family, as a last resort option against infection by Gram-negative pathogens such as Pseudomonas aeruginosa. However, the presence of positively charged α,γ-Diam...

Zhou D, Fan J, Zhang D, Ma X, Li Y, Zhang X et al.

To characterize the genomic features, antimicrobial resistance mechanisms, and biological characteristics of a carbapenem-resistant Acinetobacter pittii strain co-harboring plasmid-borne blaNDM-1 and chromosomally located blaOXA-500. An A. pittii strain (L802) was isolated from an intestinal samp...

Na TU, Hermant YO, Siow A, Owen JG, Chan STS, Painter GF et al.

A chemodiverse library of new semi-synthetic antimicrobial peptides is reported herein. The polymyxin B nonapeptide (PMBN) holds promise as a developmental platform to access potent antimicrobial lipopeptide derivatives that circumvent the serious side effects of natural polymyxins used in clinic...

Olayiwola OS, Olaniyi OO, Odunmbaku E, Fadipe TO, Oyinloye GO, Amoo RA et al.

Polyhydroxybutyrate (PHB) is a biodegradable polymer produced by bacteria under nutrient-limiting conditions, offering a sustainable alternative to petroleum plastics. This study investigated PHB production by bacterial isolates from plastic-contaminated soils. Forty isolates were screened using ...

Akomolafe SF, Granica S

Boswellia dalzielii (B. dalzielii) is traditionally used in African ethnomedicine to manage neurological and cognitive disorders. This study investigated the in vitro effects of its leaf, stem bark, and root bark extracts on key enzymes associated with brain function.The leaf, stem bark, and root...

Darji SA, Raulji A, Patel A, Pandya H, Patel R, Patel C et al.

Antimicrobial resistance (AMR) in Escherichia coli (E.coli) poses a significant global threat to public health due to increasing resistance against antibiotics. This study explored a novel combination therapy by investigating the synergistic potential of three distinct antibiotics to combat AMR i...

Ashimi AO, Sunusi UU, Ibrahim HM

Singh K, Siyadatpanah A, Garba A, Singh J, Norouzi R, Ben Said M et al.

Malaria and leishmaniasis remain major global health challenges, exacerbated by increasing resistance to current antiparasitic drugs. Medicinal plants such as Rhaponticum repens and Achillea millefolium represent potential sources of new antiparasitic compounds, although their activity against Pl...

Adesina SA, Amole IO, Adefokun IG, Adegoke AO, Ekunnrin OT, Ajala DE et al.

Dong A, Lehto M, Putaala J, Paju S, Pussinen P, Zaric S et al.

Dysbiotic oral biofilms produce virulence factors, such as lipopolysaccharide (LPS), triggering and sustaining chronic inflammation in periodontal tissues. Modulation of the bioactivity of these products offers a potential novel, adjunctive approach beyond conventional periodontal therapy.Pooled ...

Nnamani EA, Bayode AA, Alfred MO, Helmreich B, Unuabonah EI, Omorogie MO et al.

Leachate infiltration into groundwater is an intensifying environmental and public health concern in many developing countries, where waste disposal systems are poorly engineered. Phenolic contaminants pose significant ecological and human health risks but remain understudied in sub-Saharan Afric...

Surovoy YA, Galvidis IA, Alimov AI, Tsarenko SV, Burkin MA

To validate previously developed limited sampling strategies (LSS) for polymyxin B (PMB) therapeutic drug monitoring (TDM) in critically ill patients with sepsis, on renal-replacement therapy (RRT) and on extracorporeal membrane oxygenation (ECMO).Two-compartmental pharmacokinetic (PK) models wer...

Liu M, Jiang P, Ruan B, Cui Y, Zhang J, Ye Y et al.

Antimicrobial resistance (AMR) is an increasing global concern, while the development of new antibiotics remains limited. Antimicrobial peptides (AMPs) offer an alternative due to their broad-spectrum and membrane-targeting features, but their translation is restricted by instability and cytotoxi...

Duru GN, Kajihausa OE, Olatunde GO, Onabanjo OO

Production of thermo-extrudates from composite flours utilizing local crops is imperative to improving the nutritional benefits of the products and over reduction in overdependence on wheat. The study investigated the quality characteristics of thermo-extrudates made from composite flour of Afric...

Ekwe M, Fernando H, James G, Adeluyi O, Verrelst J, Kross A et al.

Leaf area index (LAI) is a key indicator of crop growth and development and is widely used in both agricultural research and precision farming applications. PlanetScope imagery is generally used for monitoring crop growth due to its high revisit frequency, broad spatial coverage, and cost-effecti...