Pinealon Research

Billeci L, Tonacci A, Accorinti I, Stefano GD, Guccione F, Milone A et al.

The failure to regulate one's own emotions, defined as Emotional Dysregulation (ED), has become a diagnostic challenge in the last decades. Peripheral indexes of functioning of the autonomic nervous system (ANS) activity emerged as reliable transdiagnostic biomarkers of psychopathology. The prese...

Edr A, Konhefr M, Krupková A, Červenková Št́astná L, Bernášková J, Kočková O et al.

Dendrimers, constituting a prominent class of monodisperse and multivalent macromolecular compounds with outstanding properties, are characterized by regular and highly branched three-dimensional architectures and well-defined chemical structures. Within each structural type, the skeletal diversi...

Pek J, Wu H, Liu Y, Dusenbery KJ, Wegener DT

Z-curve analysis is intended to diagnose the credibility of research results, but its interpretation and statistical properties are often misunderstood. We clarify that the Expected Discovery Rate (EDR; i.e. average observed power) is conceptually distinct from average pre-data power and lacks a ...

Patel JS, Tellez M, Katiyar R, Al-Hebshi NN, Santana R, Yucel RM et al.

Periodontal disease (PD) is closely linked to systemic health, with established associations with chronic conditions (eg, diabetes, cardiovascular disease). However, most predictive models rely solely on dental data, limiting the consideration of systemic factors such as medical conditions.This s...

Sun Z, Huang F, Zhang Y, Jin Y, Yang S, Gao S et al.

Monitoring the external dose rate (EDR) attenuation serves as a key consideration in supporting discharge decisions for patients with differentiated thyroid cancer (DTC) who have undergone radioiodine therapy. We aimed to study the EDR attenuation and its related factors in DTC patients during I-...

Raina GS, Mehan S, Das Gupta G

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron degeneration, oxidative stress, neuroinflammation, and neurotransmitter imbalances. This study explored the neuroprotective potential of melatonin (MLT), alone and in combination with edar...

Rahim SH, Davoody N, Bonacina S

Despite growing evidence demonstrating the connection between oral and systemic health, medical and dental care remain institutionally divided. A significant consequence of this division is the lack of information sharing, which is particularly problematic in dental care, where knowing patients' ...

Cyris M, Kopetzki L, Schulte DM, Dörfer CE, Ehrenthal JC, Graetz C et al.

Evidence on psychophysiological responses such as heart rate (HR) and electrodermal response (EDR) during long-term supportive periodontal therapy (SPT) is limited. This observational cross-sectional pilot study aimed to explore associations between patient-related factors and physiological stres...

Shimizu H, Furuya Y, Asai T, Iwama I, Tachibana H, Ishiguro Y et al.

177Lu-DOTATATE-targeted radionuclide therapy (TRT) is effective for patients with somatostatin receptor (SSTR)-positive neuroendocrine tumors; however, radiation safety regulations often necessitate hospitalization, particularly in countries with stringent discharge criteria. This study aimed to ...

Jalkanen J, Zhong J, Nono Nankam PA, Bhalla N, Elmastas M, Luo J et al.

While it is well established that the cellular composition of white adipose tissue (WAT) varies between depots, the functional relevance of this heterogeneity remains unclear. By combining spatial and single-nucleus RNA sequencing, we provide a comprehensive map of subcutaneous and visceral (omen...

Kontidou E, Collado A, Humoud R, Manickam K, Tengbom J, Jiao T et al.

Type 2 diabetes increases cardiovascular risk, with endothelial dysfunction playing a key role. Prolonged disease duration exacerbates cardiovascular risk, but the underlying mechanisms remain unclear. We previously demonstrated that red blood cells (RBCs) from individuals with type 2 diabetes im...

Nejati P, Masoumi Shahre Babak N, Sobhani Eraghi A, Nejati L, Didehvar K, Mazaherinezhad A et al.

Rotator cuff injuries are the underlying cause of shoulder pain in 65-70 % of the patients over the age of 50. A novel therapeutic approach is stem cell therapy, which promises to heal. This study represents one of the first long-term safety evaluations of autologous adipose-derived mesenchy...

Rahman OF, Lee SJ, Seeds WA

Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine. By acting on key pathways such as PI3K/Akt, mTOR, MAPK, TGF-β, and AMPK, peptides exert influen...

Vasylenko VV, Kuriata MS, Morozov VV, Lytvynets LO, Kramarenko MS, Mishchenko LP et al.

the aim of the study was to analyze the results of radiationhygienic monitoring of settlements locatedin radioactively contaminated territories (RCT) of Ukraine at the current stage of the Chornobyl accident, as well asthe dynamics of the main factors contributing to population exposure doses, ba...

Liu Y, Li X, Cui Z, Guo H, Chen X, Zhang Z et al.

Epidemiological research has identified links between dental caries and cardiovascular diseases, yet the underlying mechanisms remain insufficiently elucidated. Given the pivotal role of endothelial dysfunction in cardiovascular diseases, the cariogenic pathogen Streptococcus mutans (S.m), and th...

Mabika-Obanda AKF, Ambounda Ledaga N, Ngou Milama K, Zang Obame V, Alame-Emane AK, Sanon A et al.

Cervical cancer is a leading cause of mortality in sub-Saharan Africa, largely driven by persistent carcinogenic human papillomavirus (HPV) infection. We conducted a 3-year cross-sectional study of 1,524 women participating in the national "Octobre Rose" campaigns in Libreville, Gabon. Cervical s...

Sørensen L, Hjo C, Becker SP

Sleep disturbances are highly prevalent in children with attention-deficit/hyperactivity disorder (ADHD). Although situation-inappropriate emotion regulation is a well-established characteristic of ADHD, and sleep problems have been linked to such emotion dysregulation (EDR) in children more broa...

Jerzak KJ, Razis ED, Agostinetto E, Brastianos PK, Gatti-Mays ME, Ahluwalia MS et al.

Despite improvements in surgical techniques, advances in delivery of radiation therapy, and development of therapies with central nervous system (CNS) activity, the presence of CNS metastases from breast cancer is frequently associated with a poor prognosis. In 2023, the leadership of the Breast ...

Saklatvala JR, Lessard S, Teder-Laving M, Thomas LF, Ramessur R, Zierer J et al.

Psoriasis is a common inflammatory skin disease with heterogeneous presentation. Up to 30% of individuals have severe disease with a greater surface area of skin involvement, co-morbidity burden and impact on quality of life. Prognostic biomarkers of psoriasis severity could improve allocation of...

Judish MM, Vollmer CM, Pancreas Fistula Study Group

To identify optimal approaches to fistula mitigation for pancreatoduodenectomy.Postoperative Pancreatic Fistula (POPF) is the most consequential complication following pancreatoduodenectomy (PD). To date, the various POPF prevention methods have been investigated predominantly in isolation; howev...