PEG-MGF Research

Wu Y, Zhang L, Ma H, Wang P, Lu M, Xv X et al.

This study evaluates the efficacy and safety of optimized PEG-rhGH dosing in pre-pubertal and pubertal children with Childhood-Onset Growth Failure due to growth hormone deficiency (GHD) or non-GHD causes.This study employed a combined retrospective (n = 144) and prospective (n =&#...

Braun AC, Gutmann M, Mueller TD, Lühmann T, Meinel L

PEGylation of protein ligands, the attachment of polyethylene glycol (PEG) polymers to a therapeutic protein, increases therapeutics' half-life but frequently comes at the cost of reduced bioactivity. We are now presenting a bioinspired strategy leading out of this dilemma. To this end, we select...

Kletzl H, Guenther A, Höflich A, Höflich C, Frystyk J, Staack RF et al.

This study is a first time assessment of safety and tolerability, pharmacokinetics, and pharmacodynamics of RO5046013 in human, in comparison with unmodified rhIGF-I.The study was conducted as a single-center, randomized, double-blinded, placebo-controlled, single ascending dose, parallel group s...

Choi JW, Park JW, Na Y, Jung SJ, Hwang JK, Choi D et al.

Adenovirus (Ad) is a widely used vector for cancer gene therapy but its therapeutic efficacy is limited by low coxsackievirus and adenovirus receptor (CAR) expression in tumors and non-specifically targeted infection. Ad infectivity and specificity can be markedly improved by creating Ad-magnetic...

Ren J, Anversa P

Metabolic syndrome is a cluster of risk factors including obesity, dyslipidemia, hypertension, and insulin resistance. A number of theories have been speculated for the pathogenesis of metabolic syndrome including impaired glucose and lipid metabolism, lipotoxicity, oxidative stress, interrupted ...

Malhotra M, Tomaro-Duchesneau C, Saha S, Prakash S

Neurodegeneration is characterized by progressive loss of structure and function of neurons. Several therapeutic methods and drugs are available to alleviate the symptoms of these diseases. The currently used delivery strategies such as implantation of catheters, intracarotid infusions, surgeries...