Pasireotide Research

Gilis-Januszewska A, Bronikowska M, Binowski G, Jachimowicz M, Gueron B, Schmidt F et al.

Acromegaly is a rare and progressive condition caused by excessive secretion of growth hormone and insulin-like growth factor type 1. Pasireotide long-acting release (LAR) is indicated as a second-line therapy for adults with acromegaly who are unsuitable for or unresponsive to surgery and inadeq...

Araujo-Castro M, Lamas C, Nowak E, Newell-Price J, Reincke M, Castinetti F et al.

Medical treatment of hypercortisolism may be necessary for a high proportion of patients with Cushing´s syndrome (CS), including those who are not candidates for curative surgery. It may also be used in the presurgical period when hypercortisolism is severe, and as long-term treatment follow...

Salvio G, Ciarloni A, Aboud N, Ambo N, Bordoni M, Lucchetti B et al.

Cushing syndrome (CS) is a clinical condition caused by increased plasma cortisol levels and characterized by high cardiovascular mortality. Among the metabolic effects of CS and its treatment, glycaemic disturbances have been investigated in depth, while data on dyslipidemia is still lacking.Our...

Mondin A, Ceccato F, Scaroni C, Denaro L, Manara R, Robertazzo UM et al.

In the last few years, the use of medical treatment in Cushing's disease (CD) has increased thanks to the availability of new molecules. Nevertheless, real-life data on combination treatments are still lacking.This is a retrospective monocentric study evaluating the real-life efficacy and safety ...

Elhadd T, Dabbous Z, Abdelmahmuod EA, Rohani Z, Kailani YA

Acromegaly, a rare endocrine disorder characterised by excess growth hormone (GH) and insulin-like growth factor 1 (IGF-1), is often due to GH-secreting pituitary adenomas. Pasireotide, a second-generation somatostatin receptor ligand (SRL), binds to multiple somatostatin receptors (SSTRs) and of...

Nakayama Y, Ishikawa M, Watanabe A, Shima Y, Tahara S, Iwabu M et al.

Osilodrostat is a novel treatment for adrenocorticotropin-dependent Cushing syndrome; however, its safety during pregnancy has not been reported. This case involves a patient with Cushing disease who became pregnant while on osilodrostat. She was diagnosed at 31 years of age and underwent pituita...

Gliga MC, Chinezu L, Preda C, Rotariu DI, Pascanu MI

Acromegaly, caused by growth hormone-secreting pituitary tumors, often causes significant challenges in its management due to poor surgical outcomes and resistance to pharmacological treatment. The present study aims to explore the expression of Filamin A (FLNA), a cytoskeletal protein involved i...

Abkhiz S, Tarighi P, Azizian H

The cross-talk between mesenchymal-epithelial transition factor (c-MET) and epidermal growth factor receptor (EGFR) plays a role in breast cancer (BC) progression and resistance to various targeted therapies. Consequently, the simultaneous overexpression of c-MET and EGFR in triple-negative breas...

Fakir S, Sarker MMR, Sigdel M, Barabutis N

Growth hormone (GH) is a peptide hormone produced by the anterior pituitary gland, which regulates growth and development. Abnormal levels of GH have been associated with a diverse variety of disorders affecting life quality and longevity; including dwarfism, acromegaly, gigantism and cancer. Bas...

Vitale L, Fatti LM, Bonomi M, Frara S, Vitale G, Persani L et al.

We report the case of a 71-year-old woman with acromegalic facies, referred following bilateral idiopathic lens luxation (LL). Subsequent investigations revealed a 15-mm pituitary adenoma, along with biochemical evidence of massive growth hormone hypersecretion (Growth Hormone (GH): 93.22 µg...

Chiloiro S, Palumbo C, Giampietro A, De Marinis L, Bianchi A, Giustina A et al.

Acromegaly is a rare disease caused by the elevated and autonomous secretion of growth hormone (GH) from a pituitary somatotroph tumor or neuroendocrine tumors, and the subsequent hypersecretion of insulin-like growth factor I (IGF-I) in peripheral tissues. Excess GH and IGF-I cause several ...

Zhu X, Ye H, Lu Y, Zhang Q, Zhang H, Wu Y et al.

This study aimed to investigate the therapeutic effects of pasireotide (SOM230) on corneal nerve abnormalities in a mouse model of dry eye disease (DED) and to elucidate its potential mechanisms of action.Male C57BL/6J mice underwent lacrimal gland excision (LGE) to induce DED and were treated wi...

Agrawal N, Mehta S, Feelders RA, Skwiersky S, Campana C, Dogan F et al.

The majority of prolactinomas are treated with dopamine agonists (DA) with excellent response, however DA-resistance occurs in 10% of prolactinomas. Somatostatin (SST) receptors have been increasingly studied in prolactinomas. There are five SST receptor subtypes and a significant number of prola...

Tarvainen T, Sirén J, Kokkola A, Sallinen V

Kaparounaki C, Ilie MD, De Alcubierre D, Anagnostis P, Haidich AB, Isidori AM et al.

Acromegaly is a rare disorder caused by a growth hormone-secreting pituitary adenoma. Clinical trial evidence for its management is limited. This study compared medical treatments for acromegaly through a network meta-analysis, assessing biochemical and radiological responses.A systematic review ...

Sridharan K, Sivaramakrishnan G

Post-bariatric hypoglycemia (PBH) is a challenging and increasingly recognized complication following bariatric surgery, particularly Roux-en-Y gastric bypass (RYGB). Multiple pharmacologic interventions have been explored for managing PBH, but evidence is scattered. This study aimed to systemati...

Almalki MH, Elhadd T, AlDahmani KM, Ekhzaimy A, Alqanaei A, Jamal HF et al.

Cushing's disease (CD), most commonly caused by ACTH-secreting pituitary adenomas, is a rare but serious endocrine disorder characterized by chronic hypercortisolism. CD is associated with significant morbidity and increased mortality, necessitating timely and effective intervention.This study ai...

Cano R, Rodríguez D, Duran P, Cano C, Rojas-Gómez D, Rivera-Porras D et al.

Dumping Syndrome (DS) is a significant complication following bariatric surgery, particularly Roux-en-Y gastric bypass (RYGB). This condition is characterised by gastrointestinal and vasomotor symptoms resulting from altered anatomy and hormonal dysregulation, notably accelerated gastric emptying...

Araujo-Castro M, Biagetti B, Navas-Moreno V, Bernarda-Iriarte M, Martínez-Hernández R, Valassi E et al.

Personalized medicine has gained importance in the management of acromegaly, driven by advances in tumor classification, molecular profiling, and imaging modalities. This approach leads to achieved biochemical control more frequently and in a shorter time frame when compared to the usual trial-an...