Pancragen Research

Ikedo A, Aoki R, Sakai H, Saeki N, Yanagihara Y, Moody J et al.

The prevalence of both osteoporosis and sarcopenia increases with age and about 60% of elderly sarcopenia patients also develop osteoporosis. However, the co-occurrence of osteoporosis and sarcopenia remains unclear. We performed single-cell 5' RNA-seq on human skeletal muscle tissues and investi...

Nakamura K, Futagami S, Agawa S, Higashida S, Tanabe T, Onda T et al.

To evaluate the usefulness of the ELST-blue score to explore its potential application in identifying high-risk groups for early chronic pancreatitis (ECP) through reflecting on pancreatic elasticity and the reduction of pancreatic function, and we tried to demonstrate whether the ELST-blue score...

Kawashima R, Meller C, Suzuki M, Kato S, Horita S, Hidema S et al.

ATP-sensitive potassium (KATP) channel in pancreatic β-cells is composed of four pore-forming inward rectifier potassium (Kir) 6.2 subunits and four regulatory sulfonylurea receptor (SUR) 1 subunits and regulate insulin secretion. Kir6.2 consists of a N-terminal region, an outer transmembra...

Suzuki M, Koyama D, Hidema S, Misaka S, Wada I, Maejima Y et al.

Bupropion, a norepinephrine-dopamine reuptake inhibitor, is widely used as an antidepressant and smoking cessation aid. At high doses, it also inhibits pancreatic β-cell ATP-sensitive potassium (KATP) channels, inducing insulin secretion. KATP channels are also expressed in the brain, and t...

Hasegawa Y, Itokawa N, Kashiro A, Kitamura M, Nagashima K, Suzuki K et al.

High-risk stigmata (HRS) and worrisome features (WFs) are imaging findings that reflect malignant potential of intraductal papillary mucinous neoplasms (IPMNs). The aim of this study was to determine the potential utility of stratifying malignant potential of IPMNs using apolipoprotein-A2 isoform...

Hattori K, Shimizu M, Yamachi M, Tezuka K, Fukushima T, Yokota S et al.

Oxytocin (Oxt) is secreted to the peripheral body through the pituitary gland and can induce insulin secretion under high glucose conditions. Insulin secretion is regulated by various factors including glucagon-like peptide (GLP)-1, secreted from intestinal L-cells. GLP-1 is also expressed and se...

Murao N, Morikawa R, Seino Y, Shimomura K, Maejima Y, Yamada Y et al.

β-adrenergic blockers (β-blockers) are extensively used to inhibit β-adrenoceptor activation and subsequent cAMP production in many cell types. In this study, we characterized the effects of β-blockers on mouse pancreatic β-cells. Unexpectedly, high concentrations (1...

Kashiro A, Jung G, Honda K

Pancreatic cancer is a rare and refractory cancer, and the development of blood biomarkers for the enrichment of high-risk individuals who have risk factors for pancreatic cancer from the asymptomatic population is an unmet medical need. We identified abnormalities in the C-terminal truncation of...

Murao N, Morikawa R, Seino Y, Shimomura K, Maejima Y, Ohno T et al.

The intricate link between glucose metabolism, ATP production, and glucose-stimulated insulin secretion (GIIS) in pancreatic β-cells has been well established. However, the effects of other digestible monosaccharides on this mechanism remain unclear. This study examined the interaction betw...

Yokoi N, Adachi N, Hirokoji T, Nakano K, Yoshihara M, Shigenaka S et al.

Type 2 diabetes (T2D) is a multifactorial disease caused by insulin resistance and impaired insulin secretion from pancreatic β-cells, but the precise mechanisms remain to be elucidated. To identify primary genetic factors of T2D in a rat model, we performed comparative transcriptome and mu...

Agawa S, Futagami S, Nakamura K, Habiro M, Kawawa R, Shinagawa Y et al.

This study aimed to clarify whether several single-nucleotide polymorphisms (SNPs)-related chronic pancreatitis such as carboxypeptidase A1 (CPA1), carboxypeptidase B1 (CPB1), Gamma-glutamyltransferase 1 (GGT1), G-protein-coupled receptor Class C Group 6 Member A (GPRC6A), and serine protease inh...

Toyoda T, Miura N, Kato S, Masuda T, Ohashi R, Matsushita A et al.

Mutations of KRAS, CDKN2A, TP53, and SMAD4 are the four major driver genes for pancreatic ductal adenocarcinoma (PDAC), of which mutations of KRAS and TP53 are the most frequently recognized. However, molecular-targeted therapies for mutations of KRAS and TP53 have not yet been developed. To iden...

Nakano Y, Yokomoto-Umakoshi M, Nakatani K, Umakoshi H, Nakao H, Fujita M et al.

Adrenal incidentalomas, including nonfunctioning adrenal incidentalomas (NFAI), are associated with a high prevalence of diabetes mellitus (DM). While NFAI is diagnosed by exclusion when no hormone excess exists, subtle cortisol secretion may exist and contribute to DM development. However, it al...

Khabarov VN, Drobintseva AO, Kvetnaya TV, Mironova ES, Zubareva TS

The review describes the involvement of various hyaluronic acid receptors, including CD44, RHAMM, HARE, TLR, LYVE-1, in maintaining normal homeostasis and aging, as well as in the development of age-associated inflammatory processes (inflamaging) and malignant tumors. The association of CD44 rece...

Murao N, Morikawa R, Seino Y, Shimomura K, Maejima Y, Yamada Y et al.

Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, has been shown to improve insulin sensitivity in animal models and prediabetic patients. However, its other metabolic effects remain poorly investigated. This study examines the impact of sildenafil on insulin secretion in MIN6-K8 mouse clonal &...

Motomura S, Yumimoto K, Tomonaga T, Nakayama KI

c-Myc is a proto-oncoprotein that regulates various cellular processes and whose abnormal expression leads to tumorigenesis. c-Myc protein stability has been shown to be predominantly controlled by the ubiquitin ligase (E3) CRL1Fbxw7 in a manner dependent on glycogen synthase kinase 3 (GSK3)-medi...

Matsumoto K, Fujimori N, Ichihara K, Takeno A, Murakami M, Ohno A et al.

Recently, two molecular subtypes of pancreatic ductal adenocarcinoma (PDAC) have been proposed: the "Classical" and "Basal-like" subtypes, with the former showing better clinical outcomes than the latter. However, the "molecular" classification has not been applied in real-world clinical practice...

Mine K, Nagafuchi S, Akazawa S, Abiru N, Mori H, Kurisaki H et al.

Tyrosine kinase 2 (TYK2), a member of the JAK family, has attracted attention as a potential therapeutic target for autoimmune diseases. However, the role of TYK2 in CD8+ T cells and autoimmune type 1 diabetes (T1D) is poorly understood. In this study, we generate Tyk2 gene knockout non-obese dia...

Kashiro A, Kobayashi M, Oh T, Miyamoto M, Atsumi J, Nagashima K et al.

We have previously reported apolipoprotein A2-isoforms (apoA2-is) as candidate plasma biomarkers for early-stage pancreatic cancer. The aim of this study was the clinical development of apoA2-is.We established a new enzyme-linked immunosorbent sandwich assay for apoA2-is under the Japanese medica...

Ito M, Kubo M, Kawaji H, Otsubo Y, Kurata K, Abutani H et al.

Comprehensive genomic profiling (CGP) has become generally accepted practice in cancer care since CGP has become reimbursed by national healthcare insurance in Japan in 2019. However, its usefulness for cancer patients is insufficient for several reasons.In an observational clinical study of Foun...