Palmitoyl Tripeptide-5 Research

Xiong Y, Wu M, Hou X, Yuchun Han, Chen H, Tang H et al.

Bioactive peptides have become important ingredients in upmarket cosmetics due to their excellent biocompatibility and skincare effects. However, relatively low skin penetration and instability retard their applications. In this study, a palmitoyl peptide-based "bioactive ingredient reservoir" is...

Chen W, Xiang N, Huang J, Xu H, Wang Z, Ruan B et al.

Collagen-based skincare products can replenish collagen in the skin; however, collagen cannot easily penetrate the dermis, limiting its effectiveness. Therefore, nanomaterials that can enable collagen to effectively penetrate the dermis are urgently needed. This study aimed to determine the poten...

Luo P, Zhou K, Li G, Tao T, Tao J, Han RPS et al.

Surgical resection constitutes the first choice of treatment for colorectal cancer (CRC). Despite advancements in intraoperative navigation, there remains a considerable lack of effective targeting probes for the imaging-guided surgical navigation of CRC owing to their high heterogeneity. Hence, ...

Shariati Pour SR, Oddis S, Barbalinardo M, Ravarino P, Cavallini M, Fiori J et al.

Supramolecular and biocompatible hydrogels with a tunable pH ranging from 5.5 to 7.6 lead to a wide variety of formulations useful for many different topical applications compatible with the skin pH. An in vitro viability/cytotoxicity test of the gel components demonstrated that they are non-toxi...

Wang P, Wu J, Wang Q, Zhuang S, Zhao J, Yu Y et al.

Inflammatory coagulopathy is resulted from endothelial dysfunction and platelet hyperactivation in inflammatory diseases. In this study, the effects of baicalin, an active component of the traditional Chinese medicine Huangqin, on inflammatory coagulopathy were observed both in vivo and in vitro....

Resende DISP, Ferreira MS, Sousa-Lobo JM, Sousa E, Almeida IF

Sensitive skin is characterized by symptoms of discomfort when exposed to environmental factors. Peptides are used in cosmetics for sensitive skin and stand out as active ingredients for their ability to interact with skin cells by multiple mechanisms, high potency at low dosage and the ability t...

Denèfle T, Pramil E, Gómez-Morales L, Levasseur MD, Lardé E, Newton C et al.

In order to optimize the potency of the first serum-stable peptide agonist of CD47 (PKHB1) in triggering regulated cell death of cancer cells, we designed a maturation process aimed to mimic the trimeric structure of the thrombospondin-1/CD47 binding epitope. For that purpose, an N-methylation sc...

Avcil M, Akman G, Klokkers J, Jeong D, Çelik A

Aging skin is a gradual physiological process associated with functional and structural changes of the skin. Both intrinsic and extrinsic factors influence skin aging by the involvement of multiple pathways. Restoring natural skin conditions requires a multi-targeted approach. Recent developments...

Edwards AK, Olariu I, Nakamura DS, Ahn SH, Tayade C

Angiogenesis is an essential process in endometriosis disease progression. Earlier, we demonstrated that anti-angiogenic peptide, ABT-898 prevents neoangiogenesis of human endometriotic lesions in a xenograft mouse model. Since angiogenesis is essential for normal ovarian and uterine function, we...

Denèfle T, Boullet H, Herbi L, Newton C, Martinez-Torres AC, Guez A et al.

Thrombospondin-1 (TSP-1) is a glycoprotein considered as a key actor within the tumor microenvironment. Its binding to CD47, a cell surface receptor, triggers programmed cell death. Previous studies allowed the identification of 4N1K decapeptide derived from the TSP-1/CD47 binding epitope. Here, ...

Kalas W, Swiderek E, Switalska M, Wietrzyk J, Rak J, Strzadala L et al.

The anti-angiogenic activity of thrombospondin-1 (TSP-1) is suppressed in cancer cells, fact which has generated considerable interest in generating the respective therapeutic mimetics. These efforts were almost exclusively centered on peptides targeting CD36, the known TSP-1 receptor. Since the ...

Edwards AK, Nakamura DS, Virani S, Wessels JM, Tayade C

Endometriosis is a gynecological disease characterized by the growth of endometrium outside of the uterine cavity. It is often associated with dysmenorrhea, dyspareunia, pelvic pain and infertility. One of the key requirements for endometriotic lesions to survive is development of a blood supply ...

Audet GN, Fulks D, Stricker JC, Olfert IM

Angiogenesis is an essential process for normal skeletal muscle function. There is a growing body of evidence suggesting that thrombospondin-1 (TSP-1), a potent antiangiogenic protein in tumorigenesis, is an important regulator of both physiological and pathological skeletal muscle angiogenesis. ...

Sahora AI, Rusk AW, Henkin J, McKeegan EM, Shi Y, Khanna C et al.

Exposure to anti-angiogenic thrombospondin-1 (TSP-1) mimetic peptides (MPs) has resulted in sporadic anti-tumor activity in humans and dogs.Novel TSP-1 MPs formulations will be safe, tolerated, and clinically active in soft tissue sarcoma (STS) in dogs.Sixty-two client-owned dogs with measurable ...

Nakamura DS, Edwards AK, Virani S, Thomas R, Tayade C

Endometriosis is a common cause of pelvic pain and infertility in women, and a common indication for hysterectomy, yet the disease remains poorly diagnosed and ineffectively treated. Because endometriotic lesions require new blood supply for survival, inhibiting angiogenesis could provide a novel...

Campbell N, Greenaway J, Henkin J, Petrik J

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and is often not diagnosed until late stages due to its asymptomatic nature. Women diagnosed with EOC typically undergo surgical debulking followed by chemotherapy; however, disease recurrence often occurs. In this study, w...

Li L, Leedom TA, Do J, Huang H, Lai J, Johnson K et al.

CVX-045 is produced by covalently attaching a thrombospondin 1 (TSP-1) mimetic comprising a peptidic sequence and a linker to the Fab binding site of a proprietary scaffold antibody. CVX-045 possesses the potency of the TSP-1-derived peptide, along with the advantageous pharmacokinetics of an ant...

Campbell NE, Greenaway J, Henkin J, Moorehead RA, Petrik J

Epithelial ovarian cancer (EOC) comprises approximately 90% of ovarian cancers and arises from the surface epithelium. Typical treatment of EOC involves cytoreductive surgery combined with chemotherapy. More recent therapies have targeted the tumor vasculature using antiangiogenic compounds such ...

Nabors LB, Fiveash JB, Markert JM, Kekan MS, Gillespie GY, Huang Z et al.

To determine the maximum tolerated dose of ABT-510, a thrombospondin-1 mimetic drug with antiangiogenic properties, when used concurrently with temozolomide and radiotherapy in patients with newly diagnosed glioblastoma.Phase 1 dose-escalation clinical trial.Comprehensive Cancer Center, Universit...

Coronella J, Li L, Johnson K, Pirie-Shepherd S, Roxas G, Levin N et al.

CVX-22 is a CovX-Body, produced by covalently attaching a thrombospondin-1 (TSP-1) type 1 repeat peptide mimetic to a humanized IgG1 molecule. To dissect the antiangiogenic mechanism of CVX-22, the numbers and proliferative status of defined tumor endothelial cell (TEC) subsets from the B16 and C...