Palmitoyl Tripeptide-1 Research

Wang C, Song T, Zhang Y, Li N, Xie L, Xie M et al.

Collagen is essential for maintaining skin structure and function, and the circadian rhythm is known to regulate a wide range of physiological processes.To investigate whether collagen metabolism in human skin fibroblasts exhibits circadian regulation, and to evaluate whether the time-coordinated...

Clément C, Dorion S, Bykova NV, Fetterley V, Branchini E, Boutin C et al.

The glyoxalase pathway intermediate S-d-lactoylglutathione was recently implicated in protein post-translational modifications in animal systems. Here, we examined the spontaneous modification of the Arabidopsis thaliana cytosolic glyceraldehyde-3-phosphate dehydrogenase C1 (GAPC1) by this compou...

Teuber JP, Scissors RE, Subramani A, Madamanchi N, Brody MJ

Cardiac hypertrophy is a common adaptation to cardiovascular stress and often a prelude to heart failure. We examined how S-palmitoylation of the small GTPase, Ras-related C3 botulinum toxin substrate 1 (Rac1), impacts cardiomyocyte stress signaling. Mutation of the Cys-178 palmitoylation site im...

Paccola AGL, Santos TMCD, Minelo MC, Garbieri TF, Sanches MLR, Dionísio TJ et al.

Facial aging is a multifactorial process involving changes in bone, fat compartments, ligaments, muscles, and skin. Collagen biostimulators, including synthetic agents and autologous platelet concentrates, have gained attention for facial rejuvenation. Injectable platelet-rich fibrin (i-PRF), a s...

Yang K, Zhao H, Gao M, Hu H, Li D

: Negative energy balance (NEB) in dairy cows induces excessive lipolysis, leading to elevated levels of β-hydroxybutyric acid (BHBA), which, when accumulated, can cause liver damage. Rutin (RT), a natural flavonoid with antioxidant and anti-inflammatory properties, has demonstrated potenti...

Pan T, Tan Y, Dong X, Tang Y, Yang Z, Chen Y et al.

Abnormal aggregation of tau protein into β-sheet amyloid fibrils is closely associated with Alzheimer's disease and other tauopathies. Interactions between tau and cell membranes can lead to accelerated fibrillization and membrane deformation, serving as a toxicity pathway for tau aggregati...

Cheng Q, Huang Y, Duan W, Liu L

Current antitumor monotherapies have many limitations, and developing novel synergistic anticancer strategies with low side effects and high antitumor efficiency remains a significant challenge. Herein, we developed a pH and GSH dual-responsive pillar[5]arene-based amorphous bimetallic metal-orga...

Ligorio C, Tavasoli E, Karaman-Jurukovska N, Ittycheri A, Kotowska AM, Khan MH et al.

Self-assembling peptides (SAPs) represent a rich source of building blocks that interact with biological structures. For instance, cosmetic SAPs like Palmitoyl hexapeptide-12 have gained increasing interest for their anti-aging properties. However, their short-term impact on the skin composition ...

Mortazavi SM, Mohammadi Vadoud SA, Moghimi HR

Peptides are promising and attractive anti-wrinkle active ingredients, amongst which glycyl-histidyl-lysine peptide (GHK) is one of the most broadly promoted peptide for topical application. This simple sequence of amino acid residues not only has the capability of tissue regeneration and the enh...

Murthy NS, Tavasoli E, Mammone T, Karaman-Jurukovska N

To enable the discovery of more effective formulations for cosmetic and dermatological applications by understanding the interactions of widely used bioactive ingredients with skin biomolecular components.Affinities of six common oligopeptide utilized in biomedical application to five primary ski...

Li Z, Li X, Jiang H, Li J, Xiao B, Chen Y et al.

Previous studies have confirmed that alcohol can increase the sensitivity of the pancreas to stressors and exacerbate the severity of pancreatitis when excessive alcohol intake is combined with other causes. In the current work, this study attempted to explore how does alcohol regulate cerulein-i...

Hong M, Gui Y, Xu J, Zhao X, Jiang C, Zhao J et al.

Copper peptide, a low molecular weight peptide composed of glycyl-L-histidyl-l-lysine-copper, possesses anti-aging, anti-inflammatory, and wound healing properties. In this study, we investigated the effects of a combination agent CP-AcT, composed of palmitoyl copper peptide (pal-GHK-Cu) and acet...

Gao Y, Jin F, Zhang P, Zheng C, Zheng X, Xie J et al.

Myelodysplastic syndromes (MDS) encompass a collection of clonal hematopoietic malignancies distinguished by the depletion of peripheral blood cells. The treatment of MDS is hindered by the advanced age of patients, with a restricted repertoire of drugs currently accessible for therapeutic interv...

Howie J, Tulloch LB, Brown E, Reilly L, Ashford FB, Kennedy J et al.

Phospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity. Here, we show that the anti-oxidant protein peroxiredoxin 6 (Prdx6) interacts with and depalmitoylates PLM in a glutathione-dependent manner. Glutathione...

Chen S, Gao JJ, Liu YJ, Mo ZW, Wu FY, Hu ZJ et al.

Ferroptosis is a novel cell death mechanism that is mediated by iron-dependent lipid peroxidation. It may be involved in atherosclerosis development. Products of phospholipid oxidation play a key role in atherosclerosis. 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) is a phospholipid...

Campbell MD, Djukovic D, Raftery D, Marcinek DJ

Mitochondria adapt to increased energy demands during muscle contraction by acutely altering metabolite fluxes and substrate oxidation. With age, an impaired mitochondrial metabolic response may contribute to reduced exercise tolerance and decreased skeletal muscle mass, specific force, increased...

Alla JA, Nerger E, Langer A, Quitterer U

Membrane-Associated Guanylate Kinase (MAGUK) proteins are scaffold proteins with well-established functions in the neuronal system. A role of MAGUK protein up-regulation in the pathogenesis of heart failure is not established. This study identified the up-regulation of the MAGUK family protein MP...

Ahluwalia A, Hoa N, Moreira D, Aziz D, Singh K, Patel KN et al.

Estrogen acting through estrogen receptor β (ERβ) has been shown to oppose the stimulation of cardiac myocytes and cardiac fibroblasts that results in cardiac hypertrophy and fibrosis. Previous work has implicated signal transduction from ERβ as being important to the function o...

Lim JH, Bae JS, Lee SK, Lee DH

With age, the dermal‑epidermal junction (DEJ) becomes thinner and production of its protein components decreases; this may be associated with increased fragility and wrinkling of skin. Topical treatment with palmitoyl‑Arg‑Gly‑Asp (PAL‑RGD) improves facial wrinkl...

Fan G, Tao Z, Chen S, Zhang H, Yu R

PAC1-R is a recognized preferential receptor for the neuropeptide of pituitary adenylate cyclase-activating polypeptide (PACAP), which mediates neuroprotective and nerve regenerative activities of PACAP. In this study, we found that in both PAC1R-CHO cells with high expression of PAC1R-eGFP and r...