Palmitoyl Tetrapeptide-7 Research

Yi L, Song J, Zhang Z, Li L, Wu Y, Xue M et al.

The innate antiviral immunity of humans serves as their first line of defence against viral and microbial illnesses. The retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling pathway requires the mitochondrial antiviral signaling protein (MAVS) to function properly. ZDHHCs, a famil...

Porras M, Hernández D, Boto A

Rising antifungal resistance prompted the World Health Organization and the Food and Agriculture Organization to bring attention to the consequences of this threat to human, animal, and environmental health, and food security. In addition, there is an alarming cross-species pathogenicity. New ant...

Xing C, Hou L, Sun C, Chen H, Li Y, Li L et al.

Diabetic wounds face challenges like infection, prolonged inflammation, and poor vascularization. To address these, we developed an injectable hydrogel for diabetic wound dressing by grafting palmitoyl tetrapeptide-7 (Pal-7) onto chitosan (CS) to form CS/Pal-7 (CP7). Glutaraldehyde (GA) was used ...

Zhang B, Li Y, Yang P, He S, Li W, Li M et al.

Herpes simplex virus type 2 (HSV-2) is a sexually transmitted virus, the cause of genital herpes, and its infection can increase the risk of HIV-1 infection. After initial infection, HSV-2 can establish lifelong latency within the nervous system, which is likely associated with the virus-mediated...

Yang F, Zhang X, Wang H, Guo M, Zhang J, Feng X et al.

The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (...

Bobrov DS, Rigin NV, Lychagin AV, Artemov KD, Slinjakov LJ, Kachesov AV et al.

The main object of this prospective cohort study was to compare surgical treatment options for primary metatarsalgia and the severe instability of lesser metatarsophalangeal joints. The outcomes of triple Weil osteotomy combined with direct plantar plate repair and triple Weil osteotomy, performe...

Zhang B, Xu S, Liu M, Wei Y, Wang Q, Shen W et al.

Mitophagy is a form of autophagy that plays a key role in maintaining the homeostasis of functional mitochondria in the cell. Viruses have evolved various strategies to manipulate mitophagy to escape host immune responses and promote virus replication. In this study, the nucleoprotein (NP) of H1N...

Di D, Huang Q, Ly H, Liang Y

Lassa virus (LASV) is a mammarenavirus that can cause lethal Lassa fever disease with no FDA-approved vaccine and limited treatment options. Fatal LASV infections are associated with innate immune suppression. We have previously shown that the small matrix Z protein of LASV, but not of a nonpatho...

Longhi E, Risko C, Bacsa J, Khrustalev V, Rigin S, Moudgil K et al.

[RuCp*(1,3,5-R3C6H3)]2 {Cp* = η5-pentamethylcyclopentadienyl, R = Me, Et} have previously been found to be moderately air stable, yet highly reducing, with estimated D+/0.5D2 (where D2 and D+ represent the dimer and the corresponding monomeric cation, respectively) redox potentials of ca. -...

Resende DISP, Ferreira MS, Sousa-Lobo JM, Sousa E, Almeida IF

Sensitive skin is characterized by symptoms of discomfort when exposed to environmental factors. Peptides are used in cosmetics for sensitive skin and stand out as active ingredients for their ability to interact with skin cells by multiple mechanisms, high potency at low dosage and the ability t...

Ma P, Li L, Jin L, Zhang D, Cao X, Guo F et al.

Not only are autophagy-related (ATG) proteins the essential orchestrators of the autophagy machinery, but also they regulate many other cellular pathways. Here, we demonstrated that ATG13 exerted an obviously antiviral activity against the infection of peste des petits ruminants virus (PPRV) in c...

Tremblay MH, Zeidell AM, Rigin S, Tyznik C, Bacsa J, Zhang Y et al.

Crystallization from solutions containing 2,2'-[naphthalene-1,8:4,5-bis(dicarboximide)-N,N'-diyl]-bis(ethylammonium) diiodide ((NDIC2)I2) and PbI2 has been investigated. Eight different materials are obtained, either by variation of crystallization conditions or by subsequent thermal or solvent-i...

Murylev VY, Muzychenkov AV, Zhuchkov AG, Tsygin NA, Rigin NV, Elizarov PM et al.

Cementless knee arthroplasty becomes more and more popular worldwide. At the beginning of endoprosthetics era, cementless implants showed unsatisfactory results. However, surgical technologies develop rapidly and nowadays the cementless fixation shows better outcomes.To analyze the experience of ...

Hulushe ST, Manyeruke MH, Louzada M, Rigin S, Hosten EC, Watkins GM et al.

Crystal structures of six benzaldehyde derivatives (1-6) have been determined and their supramolecular networks were established by an X-ray crystallographic study. The study has shown that the compounds are linked by various intermolecular interactions such as weak C-H⋯O hydrogen bonding,...

Bogdanov G, Tillotson JP, Khrustalev VN, Rigin S, Timofeeva TV

The three organic two-photon-absorbing cycloalkanone chromophores 2,4-bis[4-(diethylamino)benzylidene]cyclobutanone, C26H32N2O (I), 2,5-bis[4-(diethylamino)benzylidene]cyclopentanone, C27H34N2O (II), and 2,6-bis[4-(diethylamino)benzylidene]cyclohexanone, C28H36N2O (III), were obtained by a reacti...

Rigin S, Fonari M

The mol-ecule of the title compound, C18H10Br2S4, has a C-shape, with C s mol-ecular symmetry. The dihedral angle between the planes of the di-thiol and phenyl rings is 8.35 (9)°. In the crystal, mol-ecules form helical chains along [001], the shortest inter-actions being π&#x22...

Rigin S, Armijo B, Krivoshein AV, Fonari M, Timofeeva T

A new polymorph of the title compound, C10H13NO, was obtained by recrystallization of the commercial product from a water/ethanol mixture (1:1 v/v). Crystals of the previously reported racemic and homochiral forms of 2-phenyl-butyramide were grown from water-aceto-nitrile solution in 1:1 volume r...

Bogdanov G, Tillotson JP, Khrustalev VN, Rigin S, Timofeeva TV

The synthesis, crystal structure studies and solvatochromic behavior of 2-{(2E,4E)-5-[4-(dimethylamino)phenyl]penta-2,4-dien-1-ylidene}malononitrile, C16H15N3 (DCV[3]), and 2-{(2E,4E,6E)-7-[4-(dimethylamino)phenyl]hepta-2,4,6-trien-1-ylidene}malononitrile, C18H17N3 (DCV[4]), are reported and disc...

Yuan Y, Wang X, Ren L, Kong Y, Bai J, Yan Y et al.

Interleukin-10 (IL-10) polymorphisms have been reported to be associated with systemic lupus erythematosus (SLE), however, the results are controversial. Therefore, we conducted a meta-analysis with trial sequential analysis to evaluate a more accurate estimation of the associations.Eligible stud...

Meng W, Han SC, Li CC, Dong HJ, Chang JY, Wang HR et al.

NOP53 is a tumor suppressor protein located in the nucleolus and is translocated to the cytoplasm during infection by vesicular stomatitis virus (VSV) and herpes simplex virus type 1 (HSV-1), as shown in our previous study. Cytoplasmic NOP53 interacts with the retinoic acid-inducible gene I (RIG-...