Lipopeptides, are emerging as sustainable alternatives to synthetic surfactants due to their biodegradability, low toxicity, and broad application in bioremediation, agriculture, and medicine. Endophytic microorganisms, especially those adapted to degraded environments, represent a valuable and u...
Antimicrobial agents and chemotherapy··PMID: 41218134
Alvarado-Orosco N, Gomis-Font MA, Sastre-Femenia MA, Ribera Ortiz S, Miranda Arce M, Araúz Barba ME et al.
Information on the molecular epidemiology of Pseudomonas aeruginosa and antimicrobial resistance mechanisms is still limited in some South American countries. This study aims to decipher the population structure of 111 extensive drug-resistant P. aeruginosa isolates from a national study conducte...
Ymaña B, Egoávil-Espejo R, Huerto-Huánuco R, Oporto-Llerena R, Alonso CA, Castillo AK et al.
The emergence and spread of third-/fourth-generation cephalosporin and/or carbapenem-resistant Acinetobacter baumannii have become a significant global public health concern, making new treatment alternatives necessary. Thus, the present study aimed to assess in vitro cefiderocol activity against...
Bacterial infections, particularly those caused by Gram-positive bacteria like vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA), are a growing concern. This review highlights the potential of the Streptomyces genus in producing novel antibacterial comp...
Xedzro C, Shimamoto T, Ahmed AM, Yu L, Sugawara Y, Sugai M et al.
This study aims to investigate the genomic profile of a multidrug-resistant Escherichia coli strain, 160-11H1, co-carrying an extended-spectrum β-lactamase (ESBL) and the plasmid-mediated mobile colistin resistance gene, mcr-5.The entire genome of the strain was sequenced using Illumina MiS...
Haddoudi I, Mrabet M, Cabrefiga J, Mora I, Mhadhbi H, Montesinos E et al.
A dual assault from fungal infections and abiotic stress factors such as drought and salinity increasingly threatens fava bean production. These adverse conditions not only reduce crop yield and quality but also create a more conducive environment for fungal pathogens to thrive. In this study, we...
An Enterobacter cloacae ST48 isolate exhibiting a colistin-heteroresistant phenotype was obtained from raw cow milk in Algeria. Two subpopulations were detected, both carrying the blaTEM-1 gene. While one subpopulation (E. cloacae TS34-a) was highly susceptible to colistin (MIC 0.06 µg/...
Bouali A, Bendjama E, Cherak Z, Mennaai M, Kassah-Laouar A, Rolain JM et al.
The aim of this study was to investigate the distribution and genetic determinants of carbapenemase production and colistin resistance among Acinetobacter baumannii isolates recovered from three health care facilities in the city of Batna, Algeria.A prospective study was conducted between 2021 an...
The emerging Candidozyma auris (formerly known as Candida auris, C. auris) has caused several outbreaks globally. While several studies explored the resistant biofilm formed by C. auris, little is known regarding the cells dispersed following biofilm formation. Herein, I investigated and characte...
International journal of molecular sciences··PMID: 40429801
Abdallah K, Fliss O, Pham NP, Guay LD, Gingras H, Godin C et al.
Campylobacter spp. is one of the most prevalent causes of zoonotic foodborne infections associated with diarrhea in humans. The growing threat of antibiotic resistance calls for innovative approaches. The antimicrobial lipopeptide brevibacillin produced by Brevibacillus laterosporus and its synth...
Fahmy AM, Elgendy MO, Mohamed AA, Imam MS, Alharbi AN, Al-Anezi MH et al.
Background and Objectives: Bacterial infections amongst COVID-19 patients could be associated with worsened outcomes. This study aimed to investigate the efficacy of colistin antibiotic in multidrug-resistant (MDR) Gram-negative (-ve) secondary bacterial infections among hospitalized COVID-19 pat...
Awad MA, Soliman HSM, El-Mashtoly SF, Mansour YE, El-Deeb B, Hammad SF et al.
Datura metel, a common plant in the Solanaceae family, is known for its valuable medicinal properties. The metabolites created by its rhizosphere bacterium, Sphingomonas sanguinis DM, have garnered interest for their potential biological effects. This study will discuss the steps involved in ferm...
BMC complementary medicine and therapies··PMID: 40287675
Awad MA, Mahgoub S, Soliman HSM, Hammad SF
Rhizosphere bacteria were considered a prospective reservoir of bioactive compounds with significant pharmacological efficacy.From the rhizosphere of Datura metel L., Bacillus velezensis DM was isolated and characterized using 16 S rRNA. PCR screening and sequencing were conducted to identif...
Ibrahim MJA, Mohammed Fathy MS, Ghobrial MAT, Mohamed MH
Micafungin, Amphotericin B, and Fluconazole are the primary therapeutic agents employed to address invasive fungal candidiasis in neonates. Resistance to fluconazole is gradually developing in neonatal intensive care units. We aimed to conduct a comparative analysis of Micafungin and Amphotericin...
bioRxiv : the preprint server for biology··PMID: 39974970
Laing RA, Foster MJ, Hassani MA, Kotzen B, Huang W, Shea T et al.
In the United States, Borrelia burgdorferi (Bb) is the principal etiologic agent of Lyme disease. The complex structure of Bb genomes has posed challenges for genomic studies because homology among the bacterium's many plasmids, which account for ~40% of the genome by length, has made them diffic...
Ligorio C, Tavasoli E, Karaman-Jurukovska N, Ittycheri A, Kotowska AM, Khan MH et al.
Self-assembling peptides (SAPs) represent a rich source of building blocks that interact with biological structures. For instance, cosmetic SAPs like Palmitoyl hexapeptide-12 have gained increasing interest for their anti-aging properties. However, their short-term impact on the skin composition ...
Zamorano-González CA, Ramírez-Trujillo JA, Pilotzi-Xahuentitla H, Yáñez-Ocampo G, Hernández-Nuñéz E, Suárez-Rodríguez R et al.
In the present study, the nematicidal and fungicidal activity of the biosurfactant (BS) produced by the strain Serratia ureilytica UTS was evaluated. The highest mortality of J2 juveniles of the nematode Nacobbus aberrans was 92.3% at a concentration of 30 mg/mL. Among the phytopathogenic fu...
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases··PMID: 39581546
Villa S, Escrihuela-Vidal F, Fernández-Hidalgo N, Escudero-Sánchez R, Cabezón I, Boix-Palop L et al.
To evaluate the effectiveness of ceftaroline vs. vancomycin or daptomycin in the treatment of methicillin-resistant Staphylococcus aureus bloodstream infections (BSIs) (MRSA-BSIs).This multicentre retrospective study conducted in 15 Spanish hospitals included data from the first MRSA-BSIs of adul...
Nguyen AH, Tran TT, Panesso D, Hood KS, Polamraju V, Zhang R et al.
Daptomycin is a last-resort lipopeptide antibiotic that disrupts cell membrane (CM) and peptidoglycan homeostasis. Enterococcus faecalis has developed a sophisticated mechanism to avoid daptomycin killing by redistributing CM anionic phospholipids away from the septum. The CM changes are orchestr...
Barden CJ, Wu F, Fernandez-Murray JP, Lu E, Sun S, Taylor MM et al.
The World Health Organization has identified antibiotic resistance as one of the three greatest threats to human health. The need for antibiotics is a pressing matter that requires immediate attention. Here, computer-aided drug design is used to develop a structurally unique antibiotic family tar...
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