P21 Research

Chen YJ, Mohammedsaleh ZM, He YH, Lo YH, Chang CF, Abomughaid MM et al.

Pinus morrisonicola Hayata, also known as Taiwan white pine or Taiwan short-leaf pine, is an endemic species to Taiwan. In Asia, particularly Taiwan, China, and Korea, P. morrisonicola needles have been used as a functional beverage for many years. In this study, we investigated the anti-cancer p...

Arshad MN, Bope C, Cho N, Dengler JS, Ng SFJ, Smalley JL et al.

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a severe developmental and epileptic encephalopathy characterized by early onset drug-resistant seizures and later cognitive and social impairments. Existing therapies primarily involve antiseizure medications, which have sedativ...

Punj S, Dhruv DB, Singh J, Somvanshi A, Kumar A, Abass KS et al.

Double perovskite oxides with the general formula A2BB'O₆ are widely recognized for their rich multifunctionality arising from strong spin-charge-lattice coupling. In this work, we present the successful synthesis and comprehensive characterization of Dy2NiFeO6-δ, a cobalt-free doubl...

Yang X, Xu Y, Zhang R, Xu JY, Chen WT, Chen HX et al.

Stem cell senescence and consequent decline in regenerative potential are drivers of aging and age-related disorders; however, pharmaceutical interventions targeting the delay of stem cell senescence to alleviate aging and age-related disorders remain poorly defined. Poria cocos is a well-known t...

Fei J, Yanai Y, Liu S, Manabe Y, Sugawara T

Fucoxanthin, a well-known xanthophyll obtained from marine algae, has been documented to exhibit multiple physiological and health-promoting effects. In this study, we investigated the impact of dietary administration with fucoxanthin (0.01% and 0.1%) on skin aging in 80-week-old C57BL/6J mice an...

Yang Z, Theardy MS, Chen S, Wei Y, Takeda M, Zeng Y et al.

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, with a 5-year survival rate of just 13%. While the development and early clinical use of small molecules targeting oncogenic KRAS mutations, key drivers of PDAC, have shown promise, resistance to these targeted the...

Wang Y, Lei H, Liu W, Li X, Jiang S, Zhang H et al.

Targeting the oncoprotein CSN5 represents a promising therapeutic strategy for triple-negative breast cancer (TNBC), given its critical role in stabilizing PD-L1 and promoting tumor progression. Here, we developed a novel series of 4-NH-substituted azaindole derivatives as potent CSN5 inhibitors....

Yang DL, Chao KC, Yang HT, Chen KH, Dewi L, Condello G et al.

β-Nicotinamide mononucleotide (NMN) inhibits acute inflammation in injured animal tissues.We examined whether NMN supplementation attenuates inflammation induced by blood flow restriction-resistance exercise (BFR-exercise) in human skeletal muscle.Eleven untrained men (22.8 ±&#x...

Noordhof A, Asmara OD, de Jong K, Gijtenbeek RG, Huitema YM, van Vollenhoven FH et al.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of G12C-inhibitors compared to chemotherapy in second line and beyond in adults with advanced/metastatic non-small cell lung cancer (NSCLC) with a Kirsten rat sarcoma (KRAS) G1...

Zhu Y, Liu W, Ji T, San Z, Cao R, Hayashi T et al.

Ultraviolet B (UVB) irradiation is closely associated with human skin damage. Collagen I is found to be protective against UVB-caused apoptosis in human keratinocytes HaCaT, and in this study, we further investigated the potential underlying mechanisms.Oxidative DNA damage was evaluated by assess...

Clark KR, Thomas JL, Goldberg Oppenheimer P

Günbey C, Muratoğlu B, Özdemir C, Çetinkaya DU, Yalnızoğlu D

Senescence, a steady loss of proliferative capacity triggered by complex pathways, has received attention in neurodegenerative diseases but remains obscure in epilepsy. This study aims to investigate whether the stress of frequent seizures in children triggers cellular senescence.Peripheral blood...

Xu R, Wang D, Ma G, Yuan X, Chu Q, Fan S et al.

The approval of sotorasib and adagrasib as the first KRAS G12C inhibitors has made the RAS oncogene a druggable target. However, they have modest objective response rates and short response durations. Therefore, strategies for improving RAS-targeted cancer therapy are urgently needed. Here, we fo...

Wu Y, Qin H, Qi Z, Chen Y, Huang Y, Li X et al.

Obesity is a major risk factor for metabolic disorders, including type 2 diabetes, metabolic syndrome, and cardiovascular diseases. Recent studies suggest that adipocyte cell cycle regulation is linked to metabolic dysfunction, making cell cycle regulatory factors potential therapeutic targets. Z...

Ji Y, Liu RX, He PY, Zhou YM, Li YC, Guo J et al.

Diabetic kidney disease (DKD) continues to pose a substantial public health challenge, in which cellular senescence is recognized as a pivotal driver of disease progression. While formononetin (FN) has been documented to exhibit anti-senescence properties, its potential as a therapeutic agent for...

Sánchez BG, Mora-Rodríguez JM, Bort A, Palacín A, Sánchez-Rodríguez C, Sánchez-Chapado M et al.

The transient receptor potential vanilloid 1 (TRPV1), the canonical capsaicin (CAP) receptor, has been implicated across diverse pathologies, yet its role in prostate cancer (PCa) remains elusive. Here, we uncover TRPV1 as a key regulator of PCa progression and a mediator of CAP's antiproliferati...

Zhu Y, Xu W, Wan C, Deng B, Xie Y, Yang B et al.

Acute kidney injury (AKI) is a severe clinical syndrome with high morbidity and mortality, yet its pathogenesis remains incompletely understood, and effective therapeutic strategies are still lacking. In this study, we observed significant upregulation of N-acetyltransferase 10 (NAT10) in the tub...

Zamanian M, Moradi S, Baharvand H

The conserved, pluripotency-associated miR-302/367 cluster coordinates cell fate and aging via epigenetic, cell cycle, and signaling regulation. Highly expressed in pluripotent stem cells and silenced during differentiation, it promotes efficient somatic cell reprogramming by suppressing senescen...

Liu H, Lu Z, Zhang X, Wang Y, Ge X, Chen S et al.

Recently, mitophagy-mediated bone mineralization of mesenchymal stem cells has emerged as another bone formation pattern, but whether mitophagy-mediated bone mineralization shapes craniofacial development remains unknown. Here, we demonstrate that loss of OPTN, a keystone macroautophagy/autophagy...

Liu XW, Zhang SB, Xu HW, Lu JH, Chang SJ, Huang SS et al.

Type 2 diabetes-associated osteoporosis (T2DOP) is characterized by progressive bone loss under chronic hyperglycemic stress; however, the contribution of ferroptosis to osteoblast dysfunction remains poorly understood. This study aimed to elucidate the molecular mechanisms driving osteoblast fer...